Utility of Effusion Cytology and Image Analysis in the Diagnosis of Mesothelioma

积液细胞学和图像分析在间皮瘤诊断中的应用

• 批准号: 8771979
• 负责人: Gustavo Kunde Rohde
• 金额: $ 9.38万
• 依托单位: CARNEGIE-MELLON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-07-01 至 2016-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8771979
• 关键词: Anatomy; Archives; Asbestos; Atypia; Benign; Biopsy; Biopsy Specimen; Breast; Cancer Detection; Carcinoma in Situ; Cell Nucleus; Cells; Cellular Morphology; Chest wall structure; Chromatin; Chromophobe Renal Cell Carcinoma; Classification; Clinic; Collaborations; Communities; Computer software; Cytology; Cytology procedure; Cytopathology; Data; Databases; Detection; Diagnosis; Diagnostic; Disease; Doctor of Medicine; Dysplasia; Equipment and supply inventories; Excision; Exposure to; Funding; General Hospitals; Glass; Goals; Health; Health Care Costs; Health system; Histopathology; Hospitals; Image; Image Analysis; Institution; Institutional Review Boards; Intraductal Hyperplasia; Laboratories; Liquid substance; Lung; Malignant - descriptor; Malignant Neoplasms; Malignant mesothelioma; Medicine; Mesothelial Cell; Mesothelioma; Methodology; Methods; Morphology; Nuclear Structure; Oxyphilic Adenoma; Pap smear; Pathologist; Pathology; Patients; Pattern; Pennsylvania; Phenotype; Physician Executives; Pilot Projects; Pleural; Pleural effusion disorder; Procedures; Prostate; Prostate carcinoma; Reporting; Risk; Sampling; Scientist; Specimen; Staining method; Stains; Structure; System; Techniques; Testing; Thoracoscopy; Thoracotomy; Tissues; Universities; Work; base; bladder carcinoma in situ; blind; cohort; cost; disease diagnosis; effusion; improved; mathematical algorithm; novel strategies; prognostic; prototype; public health relevance

DESCRIPTION (provided by applicant): Mesothelioma is a rare though often fatal disease, often associated with exposure to asbestos. The differentiation of malignant mesothelioma from benign mesothelial proliferation is often achieved by assessing tissue invasiveness from histological examination of biopsy specimens. Pleural effusion (fluid between lung and the chest wall) cytology is often a less invasive procedure that can be made available in most hospitals. Diagnosis of this malignancy from cytology specimens is often not possible, given that tissue invasiveness cannot be assessed. Our proposal details a pilot project to be conducted in collaboration with the System Chair of Pathology and Laboratory Medicine of Western Pennsylvania Health System (Jan F. Silverman, M.D.), as well as the Anatomic Pathology Medical Director of the Cleveland Clinic (Tarik M. Elsheikh, M.D.) to test an image analysis approach most recently developed by Dr. Rohde's laboratory at Carnegie Mellon University (CMU) for cancer detection directly from pleural effusion cytology. Preliminary results resulting from the application of Dr. Rohde's methods to data provided by Dr. Silverman (detailed in the application) indicates the method can potentially be useful for diagnosis of malignant mesothelioma. The objective of the pilot study would be to test the accuracy of the method developed by Dr. Rohde's laboratory in differentiating malignant mesothelioma from benign mesothelial proliferation directly from effusion cytology with a larger cohort of patients from two institutions (WPAHS and CC). If successful, the completion of the project could have a significant impact in reducing overall costs and avoiding health risks associated with invasive procedures. The successful completion of this project could also pave the way for the application of similar techniques on several similar cytopathology diagnostic and prognostic challenges.

描述（由申请人提供）：间皮瘤是一种罕见的，但通常是致命的疾病，通常与接触石棉有关。经常通过评估活检标本的组织学检查组织的侵入性来实现恶性间皮瘤与良性间皮增殖的分化。胸腔积液（肺部和胸壁之间的流体）细胞学通常是一种侵入性的过程，大多数医院都可以提供。鉴于无法评估组织侵入性，通常无法从细胞学标本中诊断这种恶性肿瘤。我们的建议详细介绍了一个试点项目，将与西宾夕法尼亚州西部卫生系统（Jan F. Silverman，M.D。）以及克利夫兰诊所的解剖病理学总监（Tarik M. Elsheikh，M.D。）一起测试Image分析（Rohde Carne at Carne and Carne carne carne carne carne carne carne the Carne carne carne carne of Carne the Carne carne，直接来自胸腔积液细胞学。 Rohde博士的方法应用于Silverman博士提供的数据（应用程序中的详细说明）所产生的初步结果表明，该方法可能对诊断恶性间皮瘤有可能有用。试验研究的目的是测试罗德博士实验室开发的方法的准确性 机构（WPAHS和CC）。如果成功，该项目的完成可能会对降低总体成本和避免与侵入性程序相关的健康风险产生重大影响。该项目的成功完成还可以为在几种类似的细胞病理学诊断和预后挑战上应用类似技术铺平道路。