Biological Predictors Of Brain Aging Trajectories Diversity Supplement: African American Outreach And The Intersection Between Social Determinants Of Health And Biomarkers Of Degenerative Disease
Biological Predictors Of Brain Aging Trajectories Diversity Supplement: African American Outreach And The Intersection Between Social Determinants Of Health And Biomarkers Of Degenerative Disease
批准号:
10390159
负责人:
JOEL H KRAMER
金额:
$16.99万
依托单位国家:
美国
项目类别:
财政年份:
2009
资助国家:
美国
项目状态:
已结题
起止时间:
2009-06-15 至 2024-08-31
关键词:
AffectAfrican AmericanAgeAgingAlzheimer&aposs DiseaseAmericanAmyloidAmyloid beta-ProteinAnisotropyAwardAwarenessBehavioralBiologicalBiological MarkersBiometryBlood VesselsBrainBrain PathologyCCL2 geneClinicalCognitionCognitiveComplexDegenerative DisorderDietDiseaseElderlyEndotheliumEpisodic memoryExerciseExhibitsGenomicsGoalsGoldHealth BenefitHealthcare SystemsImpaired cognitionIndividualInflammationInflammatoryInjuryInterleukin-6InterventionLife StyleLightLiquid substanceLiteratureMagnetic Resonance ImagingMapsMeasurableMeasuresMedialMemoryModelingNerve DegenerationOutcomePathologyPathway interactionsPatient Self-ReportPatternPersonsPhenotypePhysical activityPlasmaPositron-Emission TomographyPredictive ValuePreventionProcessProteinsProxyPublic HealthREM SleepRiskRoleSamplingScientific Advances and AccomplishmentsSleepStage II SleepStressStructureSubgroupSymptomsTNF geneTechniquesTemporal LobeTestingTimeWhite Matter Hyperintensityage relatedaging brainapolipoprotein E-4basecerebrovascularcognitive abilitycohortexecutive functiongray matterindividual variationinflammatory markerinnovationminimally invasivemultimodalityneurofilamentneuroimagingnoveloutreachparent grantpredictive modelingpredictive testpreventprocessing speedprotein aggregationprotein biomarkersregression treessocial health determinantstau Proteinstau-1white matterβ-amyloid burden
中文摘要
项目摘要/摘要(来自上级赠款)
认知能力随年龄变化的程度和速度存在相当大的个体差异。
我们就越能更好地理解影响衰老以及如何影响大脑结构的生物学机制
我们越有能力以针对个人的方式进行有效干预。最重要的是
此更新应用程序的目标是更好地了解炎症、血管、神经退行性变和
生活方式/行为对大脑老化轨迹的这种临床上重要的多样性做出了贡献。我们建议
继续跟踪我们由250名功能完好的老年正常人组成的深度表型队列,并提供详细的
认知、神经成像和生物特征超过两个额外的时间点。我们的首要目标是定义
生物和生活方式变量通过分离和相互作用的途径影响与年龄相关的
脑结构和功能我们的第二个目标将确定创新的血浆标志物的预测价值
与阿尔茨海默氏症和神经退行性变有关的蛋白质。我们的第三个目标将包括创新、
客观、实时地测量睡眠和体力活动。实现这些目标将具有高度的
对这一领域产生了重大影响。验证血浆病理生物标志物并阐明复杂的相互作用
了解影响大脑衰老轨迹的因素将有助于更好地预测和预防不良脑损伤
老龄化和告知针对个人的干预措施。
英文摘要
PROJECT SUMMARY /ABSTRACT (from the Parent Grant)
There is considerable individual variability in how much and how quickly cognitive abilities change with age.
The better we understand the biological mechanisms that influences if and how aging affects brain structure
and function, the more able we will be to intervene effectively in a person-specific manner. The overarching
goal of this renewal application is to better understand the inflammatory, vascular, neurodegenerative, and
lifestyle/behavioral contributions to this clinically important diversity in brain aging trajectories. We propose to
continue following our deeply phenotyped cohort of 250 functionally intact older normals with our detailed
cognitive, neuroimaging, and biometric characterizing over two additional time points. Our first aim is to define
the separate and interactive pathways by which biologic and lifestyle variables influence age-related decline in
brain structure and function Our second aim will determine of predictive value of innovative plasma markers of
proteins associated with Alzheimer’s and neurodegeneration. Our third aim will incorporate innovative,
objective, real-time measures of sleep and physical activity. Accomplishing these aims will have a highly
significant impact on the field. Validating plasma biomarkers of pathology and clarifying the complex interplay
of factors that influence brain aging trajectories will lead to better prediction and prevention of adverse brain
aging and inform person-specific interventions.
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DOI:
10.3233/jad-200755
发表时间:
2020
期刊:
Journal of Alzheimer's disease : JAD
影响因子:
--
作者:
[Asken BM, Elahi FM, La Joie R, Strom A, Staffaroni AM, Lindbergh CA, Apple AC, You M, Weiner-Light S, Brathaban N, Fernandes N, Karydas A, Wang P, Rojas JC, Boxer AL, Miller BL, Rabinovici GD, Kramer JH, Casaletto KB]
通讯作者:
Casaletto KB
DOI:
10.1080/13854046.2021.1900399
发表时间:
2022-10
期刊:
The Clinical neuropsychologist
影响因子:
--
作者:
[Stiver J, Staffaroni AM, Walters SM, You MY, Casaletto KB, Erlhoff SJ, Possin KL, Lukic S, La Joie R, Rabinovici GD, Zimmerman ME, Gorno-Tempini ML, Kramer JH]
通讯作者:
Kramer JH
DOI:
10.1002/hbm.25945
发表时间:
2022-09
期刊:
HUMAN BRAIN MAPPING
影响因子:
4.8
作者:
[Paoletti, Matteo, Caverzasi, Eduardo, Mandelli, Maria Luisa, Brown, Jesse A., Henry, Roland G., Miller, Bruce L., Rosen, Howard J., DeArmond, Stephen J., Bastianello, Stefano, Seeley, William W., Geschwind, Michael D.]
通讯作者:
Geschwind, Michael D.
Divergent patterns of loss of interpersonal warmth in frontotemporal dementia syndromes are predicted by altered intrinsic network connectivity.
额颞叶痴呆综合征中人际温暖丧失的不同模式是通过改变内在网络连接来预测的。
DOI:
10.1016/j.nicl.2019.101729
发表时间:
2019
期刊:
NeuroImage. Clinical
影响因子:
--
作者:
[Toller,Gianina, Yang,WinsonFZ, Brown,JesseA, Ranasinghe,KamaliniG, Shdo,SuzanneM, Kramer,JoelH, Seeley,WilliamW, Miller,BruceL, Rankin,KatherineP]
通讯作者:
Rankin,KatherineP
Age-related brain atrophy is not a homogenous process: Different functional brain networks associate differentially with aging and blood factors.
与年龄相关的大脑萎缩不是一个同质过程:不同的功能性脑网络将与衰老和血液因子不同。
DOI:
10.1073/pnas.2207181119
发表时间:
2022-12-06
期刊:
Proceedings of the National Academy of Sciences of the United States of America
影响因子:
11.1
作者:
[]
通讯作者:
共 26 条
Novel Imaging and Biofluid Biomarkers of Small Vessel Cerebrovascular Disease
-
批准号:10611826
-
项目类别:
-
资助金额:$108.08万
-
财政年份:2021
-
负责人:JOEL H KRAMER
-
依托单位:
Core B: Clinical Core
-
批准号:10431780
-
项目类别:
-
资助金额:$184.36万
-
财政年份:2019
-
负责人:JOEL H KRAMER
-
依托单位:
Core B: Clinical Core
-
批准号:10647904
-
项目类别:
-
资助金额:$154.06万
-
财政年份:2019
-
负责人:JOEL H KRAMER
-
依托单位:
Novel Imaging and Biofluid Biomarkers of Small Vessel Cerebrovascular Disease
-
批准号:10369292
-
项目类别:
-
资助金额:$254.76万
-
财政年份:2016
-
负责人:JOEL H KRAMER
-
依托单位:
Effects of chronic inflammation on brain structure and function
-
批准号:9217542
-
项目类别:
-
资助金额:$59.44万
-
财政年份:2015
-
负责人:JOEL H KRAMER
-
依托单位:
Effects of chronic inflammation on brain structure and function
-
批准号:9052104
-
项目类别:
-
资助金额:$46.69万
-
财政年份:2015
-
负责人:JOEL H KRAMER
-
依托单位:
Effects of chronic inflammation on brain structure and function
-
批准号:9415443
-
项目类别:
-
资助金额:$59.42万
-
财政年份:2015
-
负责人:JOEL H KRAMER
-
依托单位:
ATTENTION AND EXECUTIVE FUNCTIONING IN FRONTOTEMPORAL DEMENTIA
-
批准号:8171130
-
项目类别:
-
资助金额:$0.91万
-
财政年份:2010
-
负责人:JOEL H KRAMER
-
依托单位:
Mechanisms of Executive Decline in Normal Aging
-
批准号:8288767
-
项目类别:
-
资助金额:$54.46万
-
财政年份:2009
-
负责人:JOEL H KRAMER
-
依托单位:
Biological predictors of brain aging trajectories
-
批准号:10052959
-
项目类别:
-
资助金额:$512.71万
-
财政年份:2009
-
负责人:JOEL H KRAMER
-
依托单位:
Mechanisms of Executive Decline in Normal Aging
-
批准号:7857945
-
项目类别:
-
资助金额:$48.25万
-
财政年份:2009
-
负责人:JOEL H KRAMER
-
依托单位:
Mechanisms of Executive Decline in Normal Aging
-
批准号:8466268
-
项目类别:
-
资助金额:$48.37万
-
财政年份:2009
-
负责人:JOEL H KRAMER
-
依托单位:
ATTENTION AND EXECUTIVE FUNCTIONING IN FRONTOTEMPORAL DEMENTIA
-
批准号:7955751
-
项目类别:
-
资助金额:$0.34万
-
财政年份:2009
-
负责人:JOEL H KRAMER
-
依托单位:
Mechanisms of Executive Decline in Normal Aging
-
批准号:7662589
-
项目类别:
-
资助金额:$48.44万
-
财政年份:2009
-
负责人:JOEL H KRAMER
-
依托单位:
Mechanisms of Executive Decline in Normal Aging
-
批准号:8074919
-
项目类别:
-
资助金额:$42.35万
-
财政年份:2009
-
负责人:JOEL H KRAMER
-
依托单位:
Mechanisms of Executive Decline in Normal Aging
-
批准号:8296140
-
项目类别:
-
资助金额:$4.44万
-
财政年份:2009
-
负责人:JOEL H KRAMER
-
依托单位:
ATTENTION AND EXECUTIVE FUNCTIONING IN FRONTOTEMPORAL DEMENTIA
-
批准号:7724481
-
项目类别:
-
资助金额:$0.26万
-
财政年份:2008
-
负责人:JOEL H KRAMER
-
依托单位:
Attention and Executive Functioning in FTD
-
批准号:6943859
-
项目类别:
-
资助金额:$22.85万
-
财政年份:2004
-
负责人:JOEL H KRAMER
-
依托单位:
Cognitive and Behavioral Control in FTD
-
批准号:8106877
-
项目类别:
-
资助金额:$28.57万
-
财政年份:2004
-
负责人:JOEL H KRAMER
-
依托单位:
Decision-Making in Genetic FTD
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批准号:9319942
-
项目类别:
-
资助金额:$63.15万
-
财政年份:2004
-
负责人:JOEL H KRAMER
-
依托单位:
海外基金