Biological Predictors Of Brain Aging Trajectories Diversity Supplement: African American Outreach And The Intersection Between Social Determinants Of Health And Biomarkers Of Degenerative Disease

大脑衰老轨迹的生物预测因子多样性补充：非裔美国人的外展以及健康的社会决定因素与退行性疾病生物标志物之间的交叉

• 批准号: 10390159
• 负责人: JOEL H KRAMER
• 金额: $ 16.99万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-06-15 至 2024-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10390159
• 关键词: Affect; African American; Age; Aging; Alzheimer' s Disease; American; Amyloid; Amyloid beta-Protein; Anisotropy; Award; Awareness; Behavioral; Biological; Biological Markers; Biometry; Blood Vessels; Brain; Brain Pathology; CCL2 gene; Clinical; Cognition; Cognitive; Complex; Degenerative Disorder; Diet; Disease; Elderly; Endothelium; Episodic memory; Exercise; Exhibits; Genomics; Goals; Gold; Health Benefit; Healthcare Systems; Impaired cognition; Individual; Inflammation; Inflammatory; Injury; Interleukin-6; Intervention; Life Style; Light; Liquid substance; Literature; Magnetic Resonance Imaging; Maps; Measurable; Measures; Medial; Memory; Modeling; Nerve Degeneration; Outcome; Pathology; Pathway interactions; Patient Self-Report; Pattern; Persons; Phenotype; Physical activity; Plasma; Positron-Emission Tomography; Predictive Value; Prevention; Process; Proteins; Proxy; Public Health; REM Sleep; Risk; Role; Sampling; Scientific Advances and Accomplishments; Sleep; Stage II Sleep; Stress; Structure; Subgroup; Symptoms; TNF gene; Techniques; Temporal Lobe; Testing; Time; White Matter Hyperintensity; age related; aging brain; apolipoprotein E-4; base; cerebrovascular; cognitive ability; cohort; executive function; gray matter; individual variation; inflammatory marker; innovation; minimally invasive; multimodality; neurofilament; neuroimaging; novel; outreach; parent grant; predictive modeling; predictive test; prevent; processing speed; protein aggregation; protein biomarkers; regression trees; social health determinants; tau Proteins; tau-1; white matter; β-amyloid burden

PROJECT SUMMARY /ABSTRACT (from the Parent Grant) There is considerable individual variability in how much and how quickly cognitive abilities change with age. The better we understand the biological mechanisms that influences if and how aging affects brain structure and function, the more able we will be to intervene effectively in a person-specific manner. The overarching goal of this renewal application is to better understand the inflammatory, vascular, neurodegenerative, and lifestyle/behavioral contributions to this clinically important diversity in brain aging trajectories. We propose to continue following our deeply phenotyped cohort of 250 functionally intact older normals with our detailed cognitive, neuroimaging, and biometric characterizing over two additional time points. Our first aim is to define the separate and interactive pathways by which biologic and lifestyle variables influence age-related decline in brain structure and function Our second aim will determine of predictive value of innovative plasma markers of proteins associated with Alzheimer’s and neurodegeneration. Our third aim will incorporate innovative, objective, real-time measures of sleep and physical activity. Accomplishing these aims will have a highly significant impact on the field. Validating plasma biomarkers of pathology and clarifying the complex interplay of factors that influence brain aging trajectories will lead to better prediction and prevention of adverse brain aging and inform person-specific interventions.

项目概要/摘要（来自母基金） 随着年龄的增长，认知能力的变化程度和变化速度存在相当大的个体差异。 我们越了解影响衰老是否以及如何影响大脑结构的生物学机制 和功能，我们就越有能力以针对个人的方式进行有效干预。总体 这项更新申请的目标是更好地了解炎症，血管，神经退行性疾病， 生活方式/行为对大脑老化轨迹中这种临床重要多样性的贡献。我们建议 继续跟踪我们的250名功能完整的老年正常人的深度表型队列， 在另外两个时间点上进行认知、神经成像和生物测定表征。我们的首要目标是定义 生物学和生活方式变量影响年龄相关性下降的独立和交互途径 我们的第二个目标是确定创新的血浆标记物的预测价值， 与阿尔茨海默氏症和神经退化有关的蛋白质。我们的第三个目标将包括创新， 客观、实时地测量睡眠和身体活动。实现这些目标将具有高度的 对外地产生重大影响。验证病理学的血浆生物标志物并阐明复杂的相互作用 影响大脑老化轨迹的因素将导致更好的预测和预防不良大脑 老龄化，并告知针对个人的干预措施。

项目成果

Plasma Glial Fibrillary Acidic Protein Levels Differ Along the Spectra of Amyloid Burden and Clinical Disease Stage.

• DOI: 10.3233/jad-200755
• 发表时间: 2020
• 期刊: Journal of Alzheimer's disease : JAD
• 作者: Asken BM;Elahi FM;La Joie R;Strom A;Staffaroni AM;Lindbergh CA;Apple AC;You M;Weiner-Light S;Brathaban N;Fernandes N;Karydas A;Wang P;Rojas JC;Boxer AL;Miller BL;Rabinovici GD;Kramer JH;Casaletto KB
• 通讯作者: Casaletto KB

The Rapid Naming Test: Development and initial validation in typically aging adults.

• DOI: 10.1080/13854046.2021.1900399
• 发表时间: 2022-10
• 期刊: The Clinical neuropsychologist
• 作者: Stiver J;Staffaroni AM;Walters SM;You MY;Casaletto KB;Erlhoff SJ;Possin KL;Lukic S;La Joie R;Rabinovici GD;Zimmerman ME;Gorno-Tempini ML;Kramer JH
• 通讯作者: Kramer JH

Default Mode Network quantitative diffusion and resting-state functional magnetic resonance imaging correlates in sporadic Creutzfeldt-Jakob disease.

• DOI: 10.1002/hbm.25945
• 发表时间: 2022-09
• 期刊: HUMAN BRAIN MAPPING
• 影响因子: 4.8
• 作者: Paoletti, Matteo;Caverzasi, Eduardo;Mandelli, Maria Luisa;Brown, Jesse A.;Henry, Roland G.;Miller, Bruce L.;Rosen, Howard J.;DeArmond, Stephen J.;Bastianello, Stefano;Seeley, William W.;Geschwind, Michael D.
• 通讯作者: Geschwind, Michael D.

Divergent patterns of loss of interpersonal warmth in frontotemporal dementia syndromes are predicted by altered intrinsic network connectivity.

额颞叶痴呆综合征中人际温暖丧失的不同模式是通过改变内在网络连接来预测的。

• DOI: 10.1016/j.nicl.2019.101729
• 发表时间: 2019
• 期刊: NeuroImage. Clinical
• 作者: Toller,Gianina;Yang,WinsonFZ;Brown,JesseA;Ranasinghe,KamaliniG;Shdo,SuzanneM;Kramer,JoelH;Seeley,WilliamW;Miller,BruceL;Rankin,KatherineP
• 通讯作者: Rankin,KatherineP

Age-related brain atrophy is not a homogenous process: Different functional brain networks associate differentially with aging and blood factors.

与年龄相关的大脑萎缩不是一个同质过程：不同的功能性脑网络将与衰老和血液因子不同。

• DOI: 10.1073/pnas.2207181119
• 发表时间: 2022-12-06
• 期刊: Proceedings of the National Academy of Sciences of the United States of America
• 影响因子: 11.1