Center for Pediatric Research

儿科研究中心

• 批准号: 8711504
• 负责人: Thomas H Shaffer
• 金额: $ 188.95万
• 依托单位: ALFRED I. DU PONT HOSP FOR CHILDREN
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-09-07 至 2016-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8711504
• 关键词: Adopted; Applied Research; Area; Award; Basic Science; Biomedical Research; Centers of Research Excellence; Child; Child health care; Childhood; Clinical; Clinical Research; Communities; Delaware; Development; Discipline; Disease; Environment; Faculty; Fostering; Funding; Genetic; Goals; Grant; Growth; Institution; Laboratories; Mentors; Mission; Molecular Genetics; National Center for Research Resources; Neurosciences; Nursing Faculty; Pediatric Hospitals; Pediatric Research; Physicians; Pilot Projects; Play; Postdoctoral Fellow; Program Development; Publications; Recruitment Activity; Research; Research Activity; Research Infrastructure; Research Personnel; Research Training; Resources; Role; Scientist; Services; Students; Training; Training Programs; Translating; Translational Research; United States National Institutes of Health; career; catalyst; experience; interest; multidisciplinary; programs; success

The Center for Pediatric Research (CPR) was organized by networking a motivated group of scientists and physicians dedicated to the development and expansion of translational pediatric research. Common barriers that impede translational research were eliminated by integrating researchers from a number major disciplines in pediatric research, enabling a focus on mentored research training for physician and scientists to be maintained. This team approach to solving clinical research questions has transformed the research and clinical programs at Nemours. Our goal over the next five years is to establish the CPR as a sustainable center that drives translational research at Nemours. Building upon our existing strengths in genetics and neuroscience, we have selected four new investigators for support whose research programs fit Within the expertise of our faculty mentors.. This narrower focus will enable the CPR to establish a critical mass of investigators with overlapping research interests to attract funding and recruit new investigators needed to create a sustainable research center. A priority goal in the next cycle will be attracting additional senior faculty to the CPR to strengthen and expand our the core intellectual infrastructure. The center will be established further by integration into a state-wide network of research centers with a focus on translational research. The aims of this proposal are: 1) To provide the infrastructure to train basic and physician scientists in their quest to become investigators who can procure independent funding for their respective programs; 2) To facilitate the development of a multidisciplinary network of physicians and scientists to collaborate on basic and applied research on pediatric disorders; 3) To develop translational research programs within the NCRR network in the Delaware Valley to enrich the interface between clinical and basic research. The uniqueness of the CPR is that it has been developed specifically to provide a multidisciplinary training program for pediatric research. The long-term goal is to establish the CPR as the key infrastructural center that acts as a catalyst to develop all research programs at Nemours that are dedicated to translating research discoveries into new therapies for the benefit of children in Delaware.

儿科研究中心(CPR)是由致力于发展和扩大儿科翻译研究的一群积极进取的科学家和医生组成的网络组织的。通过将来自多个主要学科的研究人员整合到儿科研究中，消除了阻碍翻译研究的常见障碍，使医生和科学家能够继续专注于指导研究培训。这种解决临床研究问题的团队方法已经改变了Nemour的研究和临床计划。我们在未来五年的目标是将CPR建立为一个可持续发展的中心，推动Nemour的翻译研究。基于我们在遗传学和神经科学方面的现有优势，我们挑选了四名新的研究人员作为支持，他们的研究项目符合我们教员导师的专业知识。这种更窄的关注范围将使CPR能够建立具有重叠研究兴趣的临界数量的调查人员，以吸引资金并招募创建可持续研究中心所需的新调查人员。下一个周期的优先目标将是吸引更多的高级教员加入CPR，以加强和扩大我们的核心智力基础设施。该中心将通过融入以翻译研究为重点的全州研究中心网络而进一步建立。这项建议的目的是：1)提供基础设施，培训基础和内科科学家，使他们成为能够为各自项目获得独立资金的研究人员；2)促进多学科医生和科学家网络的发展，以合作进行儿科疾病的基础和应用研究；3)在特拉华州山谷的NCRR网络内开发转化性研究计划，以丰富临床和基础研究之间的接口。CPR的独特之处在于，它是专门为儿科研究提供多学科培训计划而开发的。长期目标是将CPR建立为关键的基础设施中心，作为催化剂来发展Nemour的所有研究计划，致力于将研究发现转化为新的治疗方法，造福特拉华州的儿童。

项目成果

Xenograft and genetically engineered mouse model systems of osteosarcoma and Ewing's sarcoma: tumor models for cancer drug discovery.

• DOI: 10.1517/17460441.2013.817988
• 发表时间: 2013-10
• 期刊: Expert opinion on drug discovery
• 影响因子: 6.3
• 作者: Sampson VB;Kamara DF;Kolb EA
• 通讯作者: Kolb EA

Peptide Hydrogels - Versatile Matrices for 3D Cell Culture in Cancer Medicine.

• DOI: 10.3389/fonc.2015.00092
• 发表时间: 2015
• 期刊: Frontiers in oncology
• 影响因子: 4.7
• 作者: Worthington P;Pochan DJ;Langhans SA
• 通讯作者: Langhans SA

Transcriptional regulators of Na,K-ATPase subunits.

• DOI: 10.3389/fcell.2015.00066
• 发表时间: 2015
• 期刊: Frontiers in cell and developmental biology
• 影响因子: 5.5
• 作者: Li Z;Langhans SA
• 通讯作者: Langhans SA

Neuromotor synapses in Escobar syndrome.

埃斯科瓦尔综合征的神经运动突触。

• DOI: 10.1002/ajmg.a.36154
• 发表时间: 2013
• 期刊: American journal of medical genetics. Part A
• 作者: Robinson,KarynG;Viereck,MatthewJ;Margiotta,MeganV;Gripp,KarenW;Abdul-Rahman,OmarA;Akins,RobertE
• 通讯作者: Akins,RobertE

Newborn screening and diagnosis of mucopolysaccharidoses: application of tandem mass spectrometry.

新生儿粘多糖病的筛查和诊断：串联质谱法的应用。

• 发表时间: 2014
• 期刊: Nihon Masu Sukuriningu Gakkai shi = Journal of Japanese Society for Mass-Screening
• 作者: Tomatsu,Shunji;Kubaski,Francyne;Sawamoto,Kazuki;Mason,RobertW;Yasuda,Eriko;Shimada,Tsutomu;Montaño,AdrianaM;Yamaguchi,Seiji;Suzuki,Yasuyuki;Orii,Tadao
• 通讯作者: Orii,Tadao