DE PEDIATRIC COBRE: ADMINISTRATIVE CORE

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 科布雷提案的主要目标是增加特拉华州活跃的、由NIH资助的生物医学研究人员的数量。这将通过内穆尔研究所/阿尔弗雷德·I·杜邦儿童医院的一个多学科研究小组的努力来实现，以研究儿科疾病、治疗和预防。内穆斯研究所位于特拉华州威尔明顿的阿尔弗雷德·I·杜邦医院，两家医院之间保持着密切的关系。新的研究中心，即儿科研究中心(CPR)，将专注于三个目标：1)发展一个中心，通过提供基础设施来培训基础和内科科学家(目标调查人员)，以支持儿科疾病的基础和应用研究，使他们成为能够成功地为其研究项目获得外部资金的独立调查人员。CPR将通过为项目提供资金、资源和核心实验室服务来促进这些初级科学家的发展；2)制定综合指导计划，以丰富目标调查人员的培训。在科学研究和拨款申请方面拥有丰富历史的资深研究人员将为目标研究人员提供科学和学术指导，从而促进这一核心科学家群体的进步，以建立更强大的研究计划，确保特拉华州生物医学研究的长期扩展；以及3)在CPR内开发一个转换研究计划，通过开发与临床相关的基础研究系统以及科学合理的临床研究方法，丰富临床和基础研究之间的接口。我们将招募在临床和应用基础研究方面有经验的研究人员，组成一个研究儿科疾病的多学科研究小组，为NIH资助的内穆尔研究所翻译CPR的长期发展提供额外的研究计划和基础设施。这里提出的Cobre计划将有两个长期好处：1)特拉华州具有竞争力的NIH研究人员的数量将会增加；2)CPR将准备申请其他中心的拨款，这在特拉华州是很少的。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The primary goal of this COBRE proposal is to increase the number of active, NIH-funded biomedical researchers in the State of Delaware. This will be accomplished through the efforts of a multidisciplinary group of investigators at the Nemours Research Institute/Alfred I. duPont Hospital for Children, to study pediatric diseases, therapy and prevention. The Nemours Research Institute is located on the grounds of the Alfred I. duPont Hospital in Wilmington, Delaware, where a close relationship is maintained between the two facilities. The new research center, The Center for Pediatric Research (CPR,) will focus on three aims: 1) To develop a Center that will support basic and applied research on pediatric disorders by providing the infrastructure to train basic and physician scientists (target investigators) in their quest to become independent investigators who can successfully procure outside funding for their research programs. The CPR will foster the development of these junior scientists by providing the money, resources and core lab services for the projects; 2) To develop an integrated mentoring program to enrich the training of the target investigators. Established investigators with proven histories in scientific research and grant acquisition will provide scientific and academic direction to the target investigators, thus fostering the advancement of this core group of scientists to build a stronger research program, ensuring the long-term expansion of biomedical research in Delaware; and 3) To develop a translational research program within the CPR that enriches the interface between clinical and basic research by developing clinically relevant systems for basic research as well as scientifically sound approaches to clinical research. We will recruit investigators with experience in clinical and applied basic research to form a multidisciplinary research group studying pediatric diseases, providing additional research programs and infrastructure for the long-term development of an NIH-funded translational CPR at the Nemours Research Institute. The COBRE program proposed herein will have two long-term benefits: 1) the number of NIH-competitive researchers in Delaware will increase; 2) the CPR will be poised to apply for other Center grants, which are few in Delaware.