Rapid and On-site Monitoring of Urinary Arsenic Metabolites

描述(由申请人提供)：Giner，Inc.提出了一种便携式、廉价和快速反应的尿砷形态监测仪。尿中排出的砷物种反映了接触有毒砷物种的情况，因此这项监测将是一个有价值的工具。 在医学诊断和流行病学研究中，通过使用一种比传统方法更快、更便宜的技术来确定砷暴露。提高监测暴露的能力将产生积极的公共健康结果，因为长期暴露在砷中与包括癌症和心血管疾病在内的健康问题有关。第一阶段计划开发了一种能够电化学检测砷(III)、总无机砷和二甲基砷酸的传感器。总有机砷的测定通过样品处理过程，然后进行电化学检测。第二阶段计划将包括进一步优化所有方法和流程，设计一个原型设备，并用流行病学研究中的真实尿样对该设备进行验证。第二阶段计划将产生一个实用、坚固和准确的砷形态分析装置。

DESCRIPTION (provided by applicant): Giner, Inc. proposes a portable, inexpensive, and rapid-response monitor for arsenic speciation in urine. Arsenic species excreted in urine are reflective of exposure to toxic arsenic species, and therefore this monitor will be a valuable tool in medical diagnostics and epidemiological studies by allowing determination of arsenic exposure by a technique that is faster and less expensive than traditional methods. Improved capability of monitoring exposure will have positive public health outcomes, as long- term exposure to arsenic is associated with health problems including cancer and cardiovascular disease. The phase I program developed a sensor capable of electrochemical detection of arsenic (III), total inorganic arsenic, and dimethylarsenic acid. Total organic arsenic was determined through a sample treatment process followed by electrochemical detection. The phase II program will include further optimization of all methods and processes, design of a prototype device, and validation of the device with real urine samples from epidemiological studies. The phase II program will result in a practical, robust, and accurate arsenic speciation device.