Physician Monitoring System for Nicotine and Metabolites

尼古丁和代谢物的医生监测系统

• 批准号: 8196685
• 负责人: BADAWI M DWEIK
• 金额: $ 17.99万
• 依托单位: GINER, INC.
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-05-01 至 2013-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8196685
• 关键词: Addictive Behavior; Alcohols; Algorithms; Architecture; Behavior; Biological; Biological Assay; Biological Monitoring; Boron; Bupropion; Cessation of life; Clinic; Clinical; Communication; Computer software; Computers; Cotinine; Coupled; Data; Detection; Development; Diamond; Electrodes; Electrolytes; Ensure; Environmental Tobacco Smoke; Equipment; Evaluation; Exposure to; Goals; Hand; Health; Healthcare; High Pressure Liquid Chromatography; Home environment; Housing; Human; Individual; Laboratories; Laboratory Research; Lead; Mass Spectrum Analysis; Measurement; Measures; Medical; Methods; Microelectrodes; Monitor; Nicotine; Patients; Performance; Personal Satisfaction; Pharmacotherapy; Phase; Physicians; Physicians' Offices; Physiologic pulse; Plasma; Price; Procedures; Protocols documentation; Psychiatry; Reaction; Reporting; Research; Resolution; Sampling; Signal Transduction; Simulate; Site; Small Business Innovation Research Grant; Smoker; Smoking; Smoking and Health Research; Solutions; Solvents; System; Techniques; Technology; Testing; Time; Tobacco; Tobacco smoke; Tobacco use; United States; Universities; Urine; Validation; Visit; Work; addiction; analog; base; cigarette smoking; comparative; cost; cost effective; design; effective therapy; experience; hydroxycotinine; improved; innovation; instrument; instrumentation; medical specialties; meetings; nicotine replacement; novel; premature; professor; programs; prototype; research study; response; sensor; smoking cessation; success; technology development; tool; user-friendly

DESCRIPTION (provided by applicant): Cigarette smoking and secondhand exposure to tobacco smoke cause an estimated average of 438,000 premature deaths each year in the United States. Nicotine, coadministered in tobacco products, is an addicting substance that causes individuals to continue use of tobacco despite concerted efforts to quit. Nicotine-metabolites monitoring is an important tool for monitoring smoker addictions and treatment. Current monitoring techniques utilize analytic equipment that is based in a clinical analytical laboratory making monitoring inconvenient and costly. There is currently no commercially-available monitoring system suitable for physician's office use. This proposed program will develop an advanced, rapid, and convenient home and physician office-based system which could make a significant impact in the health and well-being of those individuals being treated for smoking. The innovation in the proposed work is to develop an electrochemical sensor comprised of a novel high performance microelectrode utilizing a sensitive and selective electrochemical technique to measure nicotine-metabolites concentration in the clinical setting from urine samples. The development of the proposed electrochemical detection method is key to the demonstration of product feasibility and is the emphasis in Phase I. The hardware and software for the electrochemical technique are commercially available at a reasonable price for adaptation to this application. The final product will have the ease of use of an office monitor and provide the clinician with nicotine-metabolites measurements needed for optimal and cost-effective treatment of the patient. The Phase I project is designed to determine the feasibility of the proposed electrochemical method. Phase I will include: 1) optimization of an advanced material microsensor chip electrode; 2) selection of electrolyte and solvent; 3) development of a powerful electroanalytical algorithm for sensitive and selective detection of nicotine and it metabolites in urine analog solutions; 4) testing of the developed technique; and 5) design of a Phase II integrated instrument. PUBLIC HEALTH RELEVANCE: The proposed project is to develop a portable, self-contained, easy-to-use, electrochemical monitor for simultaneous on-site measurement of nicotine and its major metabolites [cotinine (COT) and 3-hydroxycotinine (3HC)] from a single urine sample in near real time to assess personal exposure. The ability to accurately, conveniently, safely and cost-effectively measure nicotine, COT and 3HC in physician's offices with the results reported to the clinician would improve treatment and monitoring with lower cost. The test will be user-friendly for use in physician's offices to optimize and personalize smoking cessation programs that include nicotine replacement and buproprion pharmacotherapies. The monitor also has the potential to be sufficiently sensitive to detect exposure to second hand smoke for health monitoring and research studies.

描述（由申请人提供）：在美国，吸烟和二手接触烟草烟雾估计每年平均导致438，000人过早死亡。尼古丁，在烟草产品中共同管理，是一种成瘾物质，导致个人继续使用烟草，尽管共同努力戒烟。尼古丁代谢物监测是监测吸烟者成瘾和治疗的重要工具。当前的监测技术利用基于临床分析实验室的分析设备，使得监测不方便且昂贵。目前没有适合医生办公室使用的市售监测系统。该计划将开发一种先进，快速，方便的家庭和医生办公室系统，这可能会对那些正在接受吸烟治疗的人的健康和福祉产生重大影响。在拟议的工作中的创新是开发一种电化学传感器，包括一种新型的高性能微电极，利用灵敏和选择性的电化学技术来测量尼古丁代谢物的浓度在临床环境中的尿液样本。拟定电化学检测方法的开发是产品可行性论证的关键，也是第一阶段的重点。用于电化学技术的硬件和软件可以以合理的价格商购获得，以适应该应用。最终产品将具有办公室监测器的易用性，并为临床医生提供对患者进行最佳和具有成本效益的治疗所需的尼古丁代谢物测量。第一阶段项目旨在确定所提出的电化学方法的可行性。第一阶段将包括：1）先进材料微传感器芯片电极的优化; 2）电解质和溶剂的选择; 3）开发一种功能强大的电分析算法，用于灵敏和选择性地检测尿液模拟溶液中的尼古丁及其代谢物; 4）测试所开发的技术;以及5）设计II期集成仪器。 公共卫生相关性：拟议项目是开发一种便携式、独立、易于使用的电化学监测仪，用于在接近真实的时间内同时现场测量单个尿液样本中的尼古丁及其主要代谢物[可替宁（COT）和3-羟基可替宁（3 HC）]，以评估个人暴露情况。在医生的办公室中准确、方便、安全和具有成本效益地测量尼古丁、COT和3 HC并将结果报告给临床医生的能力将以较低的成本改善治疗和监测。该测试将是用户友好的，可在医生办公室使用，以优化和个性化戒烟计划，包括尼古丁替代和安非他酮药物治疗。该监测器还具有足够的灵敏度，可以检测到二手烟暴露，用于健康监测和研究。