Rapid and On-site Monitoring of Urinary Arsenic Metabolites

描述(由申请人提供)：Giner，Inc.提出了一种便携式、廉价和快速反应的尿砷形态监测仪。尿中排出的砷反映了人类接触有毒砷的情况，因此该传感器将成为医学诊断和流行病学研究中有价值的生物监测工具，因为它可以比传统方法更快、更便宜地确定砷暴露。提高监测暴露的能力将产生积极的公共健康结果，因为长期暴露在砷中与包括癌症和心血管疾病在内的健康问题有关。第一阶段计划将开发一种监测原型，能够使用先进的电极衬底直接电化学检测尿中的砷(III)。其他重要的砷形态和代谢物(砷[V]和一甲基和二甲基阿司匹林)的定量将通过化学和电化学方法顺序和快速转化为砷(III)，从而获得尿中有毒砷的总量。第一阶段计划的可行性研究将包括用流行病学研究中的真实尿样验证阿尔法原型。第二阶段计划将产生一个实用的、坚固的、高精度的能够进行现场分析的设备。 公共卫生相关性：提出了一种便携式、廉价和快速响应的监测仪，用于分析尿中无机砷和砷代谢物的形态。传统的砷暴露评估方法时间密集，成本高昂，因此，这种低成本的现场监测将通过提高监测高危人群砷暴露的能力，产生积极的公共卫生结果。

DESCRIPTION (provided by applicant): Giner, Inc. proposes a portable, inexpensive, and rapid-response monitor for arsenic speciation in urine. Arsenic species excreted in urine are reflective of human exposure to toxic arsenic, and therefore this sensor will be a valuable biomonitoring tool in medical diagnostics and epidemiological studies by allowing determination of arsenic exposure faster and less expensive than traditional methods. Improved capability of monitoring exposure will have positive public health outcomes, as chronic exposure to arsenic is associated with health problems including cancer and cardiovascular disease. The Phase I program will develop a monitor prototype capable of direct electrochemical detection of arsenic (III) in urine with an advanced electrode substrate. Quantification of other important arsenic species and metabolites (arsenic [V] and mono- and dimethyl arsinate) will be performed by sequential and rapid conversion to arsenic (III) via chemical and electrochemical methods to obtain the total amount of toxic arsenic in urine. The phase I program feasibility studies will include validation of the alpha prototype with real urine samples from epidemiological studies. The phase II program will result in a practical, robust, and highly accurate device capable of on-site analysis. PUBLIC HEALTH RELEVANCE: A portable, inexpensive, and rapid-response monitor for speciation analysis of inorganic arsenic and arsenic metabolites species in urine is proposed. Traditional methods of assessing arsenic exposure are time-intensive and cost-prohibitive, and therefore such low cost onsite monitor will have positive public health outcomes by improving ability to monitor arsenic exposure in at-risk populations.