Rapid and On-site Monitoring of Urinary Arsenic Metabolites

描述（由申请人提供）：Giner, Inc.提出了一种便携式，廉价，快速反应的尿液中砷形态监测仪。尿液中排泄的砷种类反映了人体对有毒砷的暴露，因此这种传感器将成为医学诊断和流行病学研究中有价值的生物监测工具，可以比传统方法更快、更便宜地确定砷暴露。改善监测接触的能力将产生积极的公共卫生结果，因为长期接触砷与包括癌症和心血管疾病在内的健康问题有关。第一阶段项目将开发一种监测原型，能够使用先进的电极衬底直接电化学检测尿液中的砷（III）。其他重要的砷种类和代谢物（砷[V]和砷一甲基和二甲基砷酸盐）的定量将通过化学和电化学方法依次快速转化为砷（III）来进行，以获得尿液中有毒砷的总量。第一阶段项目可行性研究将包括用流行病学研究中的真实尿液样本验证alpha原型。第二阶段的项目将产生一种实用的、坚固的、高度精确的设备，能够进行现场分析。

DESCRIPTION (provided by applicant): Giner, Inc. proposes a portable, inexpensive, and rapid-response monitor for arsenic speciation in urine. Arsenic species excreted in urine are reflective of human exposure to toxic arsenic, and therefore this sensor will be a valuable biomonitoring tool in medical diagnostics and epidemiological studies by allowing determination of arsenic exposure faster and less expensive than traditional methods. Improved capability of monitoring exposure will have positive public health outcomes, as chronic exposure to arsenic is associated with health problems including cancer and cardiovascular disease. The Phase I program will develop a monitor prototype capable of direct electrochemical detection of arsenic (III) in urine with an advanced electrode substrate. Quantification of other important arsenic species and metabolites (arsenic [V] and mono- and dimethyl arsinate) will be performed by sequential and rapid conversion to arsenic (III) via chemical and electrochemical methods to obtain the total amount of toxic arsenic in urine. The phase I program feasibility studies will include validation of the alpha prototype with real urine samples from epidemiological studies. The phase II program will result in a practical, robust, and highly accurate device capable of on-site analysis. PUBLIC HEALTH RELEVANCE: A portable, inexpensive, and rapid-response monitor for speciation analysis of inorganic arsenic and arsenic metabolites species in urine is proposed. Traditional methods of assessing arsenic exposure are time-intensive and cost-prohibitive, and therefore such low cost onsite monitor will have positive public health outcomes by improving ability to monitor arsenic exposure in at-risk populations.