Biostatistics, Computational & Data Management (BCDM) Core

这个修订后的孔特中心的项目整合了人类和啮齿动物模型的研究，以探索 支离破碎和/或不可预测的早期生活经历增加了发展中的脆弱性 个人的情绪和认知障碍。对中心的具体目标进行表征和量化 跨物种的零散和不可预测的母体信号，并检查这些信号对 结果轨迹；使用成像和分子分析来探索碎片化和 不可预测的母体信号会增加情绪和认知问题的脆弱性；并造成 母体信号碎片化对情绪和心理健康影响的综合预测模型 青春期的认知脆弱性。根据评审员的建设性建议，我们提供 在这份经修订的申请中，提供了关于生物和清洁发展机制核心的更具体和详细的信息。 生物统计、计算和数据管理核心的主要目标是：(A)加强 通过开发新的和生物相关的碎片化措施和 不可预测性；(B)向各种中心项目和核心提供数据管理支助，使 协调一致的分析；和(C)通过与个别项目和 支持他们的分析的核心，重要的是协调跨项目的结果集成到 开发与临床相关的预测模型。从本质上讲，核心将与中心调查人员合作 探索表征早期感觉信号的各种方法，将这些信号与 行为、功能和成像结果，探索在人类队列中的纵向后果，以及 协调数据管理和数据集成(与成像核心一起工作)。

The projects of this revised Conte Center integrate human and rodent-model studies to explore the role of fragmented and/or unpredictable early-life experiences in increasing the vulnerability of developing individuals to emotional and cognitive disorders. Specific aims for the Center characterize and quantify fragmented and unpredictable maternal signals across species and examine the impact of such signals on outcome trajectories; use imaging and molecular analyses to explore mechanisms by which fragmented and unpredictable maternal signals promote vulnerabilities to emotional and cognitive problems; and create an integrated and predictive model for the contribution of fragmented maternal signals to emotional and cognitive vulnerabilities during adolescence. Guided by the Reviewers' constructive suggestions, we provide in this revised application more specific and detailed information about the BCDM Core. The primary goals of the Biostatistics, Computation and Data Management Core are: (a) enhance the innovation of the Center by developing novel and biologically relevant measures of fragmentation and unpredictability; (b) provide data management support to the various Center projects and cores that enable coherent analyses; and (c) enhance the impact of the Center by collaborating with individual projects and cores to support their analyses and, importantly, coordinate the integration of results across projects to develop clinically relevant predictive models. In essence, the Core will work with Center investigators to explore a variety of measures for characterizing early-life sensory signals, correlate those signals with behavioral, functional, and imaging outcomes, explore the longitudinal consequences in a human cohort, and coordinate data management and data integration (working with the Imaging Core).