Translational Core for Therapeutic and Diagnostic Development

项目摘要：治疗和诊断开发的翻译核心 治疗和诊断开发的翻译核心(TCTDD)将加强研究 越来越多的R01资助从事基础科学研究的研究人员的计划 强大的新数据科学和高通量数据分析支持。目前，NEI R01赠款由 这个P30助学金从事基础生物医学研究(T0研究)，有明确的翻译目标 眼科疾病诊断、治疗和预防新方法的研究成果(T1研究)。这个 TCTDD核心将提供数据科学和人工智能(AI)服务，用于预处理、分析和 基础研究数据(分子、细胞和成像)的可视化，以提供更深入的机械洞察和 转向翻译研究的协同机会(目标1)。TCTDD核心还将提供 以技术为驱动的自动化服务，以支持研究吞吐量，以产生高质量、严谨的 研究数据，将拓展基础科学研究的广度和深度，同时加速相关 翻译研究(目标2)。长期目标是加速发现，这些发现很容易从替补席转移到- 在床边。

PROJECT SUMMARY: TRANSLATIONAL CORE FOR THERAPEUTIC AND DIAGNOSTIC DEVELOPMENT The Translational Core for Therapeutic and Diagnostic Development (TCTDD) will enhance the research programs of a growing number of R01 funded investigators engaged in basic science research by providing powerful new data science and high throughput data analysis support. Currently, NEI R01 grants supported by this P30 grant are engaged in basic biomedical research (T0 research) with explicitly stated goals of translation of research findings for new methods of diagnosis, treatment, and prevention of eye diseases (T1 research). The TCTDD core will provide Data Science and Artificial Intelligence (AI) services for pre-processing, analysis and visualization of basic research data (molecular, cellular and imaging) to provide deeper mechanistic insights and synergistic opportunities for moving towards translational research (Aim 1). The TCTDD core will also provide technology-driven, automated services to bolster the research throughput for generating high quality, rigorous research data which will expand the breadth and depth of basic science research while accelerating related translational research (Aim 2). The long-term goal is to accelerate discoveries that easily transit from bench-to- bedside.