Bioinformatics Core

生物信息学核心

• 批准号: 8870383
• 负责人: FAYE SCHILKEY
• 金额: $ 76.6万
• 依托单位: NEW MEXICO STATE UNIVERSITY LAS CRUCES
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/8870383
• 关键词: Academia; Achievement; Adopted; Area; Bioinformatics; Biological Phenomena; Biomedical Research; Biotechnology; Cancer Biology; Chromatin Structure; Collaborations; Color; Communication; Complex; Consult; DNA Methylation; DNA Resequencing; DNA Sequence; Data; Databases; Dedications; Development; Diagnostic Procedure; Disease; Drug Industry; Educational workshop; Emerging Technologies; Faculty; Fluorescence; Foundations; Gene Expression Profile; Generations; Genes; Genome; Genomics; Genotype; Germ Lines; Goals; Health Professional; Homo sapiens; Housing; Individual; Internships; Knowledge; Knowledge Discovery; Mentorship; MicroRNAs; Mining; Mission; Molecular; New Mexico; North America; Productivity; Provider; RNA Splicing; Regulation; Research; Research Infrastructure; Research Institute; Research Personnel; Research Support; Resources; Role; Scientist; Series; Services; Software Tools; Students; Surveys; Techniques; Technology; Training; Training and Education; Universities; Variant; base; biological research; biomedical scientist; cohort; college; data mining; education planning; experience; field study; functional genomics; genome sequencing; individualized medicine; innovation; mRNA Expression; next generation; next generation sequencing; operation; outreach; personalized genomic medicine; personalized medicine; prognostic; research study; skills; software development; symposium; teacher; tool; trait; transcriptomics

. NGS technologies have transformed the way in which research is conducted. The sheer scale of inquiry has been expanded to the extent that whole genomes and transcriptomes of cohorts of individuals can be surveyed in a single experiment. Moreover, sequencing can be used to probe biological phenomena at multiple levels of regulation, including germ-line variation, DNA methylation, mRNA expression and splice form abundance, microRNA expression, and chromatin structure exploration. NGS is also displacing other technologies, in particular the use of fixed-content chips for genotyping. NGS is being applied in every field of biological research, and will be an essential tool in the development of individualized medicine. Sequence data without sophisticated bioinformatics is essentially useless. Having a technology partner consisting of an experienced team of bioinformatics researchers and analysts, co-located with the sequencing operation is unprecedented in New Mexico. The SBC will continue to provide the network turn-key access to discovery¿ enabling sequencing and bioinformatics.

。 NGS 技术改变了研究的方式。其规模之大 调查范围已经扩大到可以在一次实验中调查个体群体的整个基因组和转录组。此外，测序可用于探测多个调控水平的生物现象，包括种系变异、DNA甲基化、mRNA表达和剪接形式丰度、microRNA表达和染色质结构探索。 NGS 也正在取代其他技术，特别是使用固定内容芯片进行基因分型。 NGS正在应用于生物学研究的各个领域，并将成为个体化医学发展的重要工具。没有复杂的生物信息学的序列数据本质上是无用的。在新墨西哥州，拥有一个由经验丰富的生物信息学研究人员和分析师团队组成的技术合作伙伴与测序操作位于同一地点是前所未有的。 SBC 将继续提供网络统包访问以实现测序和生物信息学的发现。