2015 Modulation of Neural Circuits & Behavior Gordon Research Conference

2015 神经回路的调制

• 批准号: 8909848
• 负责人: Andres Villu Maricq
• 金额: $ 1.5万
• 依托单位: GORDON RESEARCH CONFERENCES
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-04-15 至 2016-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8909848
• 关键词: American; Asia; Asians; Attention deficit hyperactivity disorder; Australia; Behavior; Behavior Control; Behavioral; Biological Models; Brain; China; Cognitive; Collaborations; Country; Defect; Development; Dopamine; Effectiveness; Emotional; Emotions; Ethology; Europe; Faculty; Future; Genetic; Genetic Engineering; Goals; Growth Factor; Homeostasis; Hong Kong; Institutes; Invertebrates; Japan; Korea; Link; Location; Memory; Mental Depression; Mental Health; Mental disorders; Mission; Modeling; Motivation; National Institute of Drug Abuse; National Institute of Mental Health; National Institute of Neurological Disorders and Stroke; Neurology; Neuromodulator; Neurons; Neurosciences Research; Participant; Pathway interactions; Peptides; Plastics; Postdoctoral Fellow; Property; Psychiatry; Request for Proposals; Research; Role; Scientist; Serotonin; Shapes; Signal Pathway; Signal Transduction; Sister; Synaptic plasticity; Systems Biology; Talents; Techniques; United States; United States National Institutes of Health; Update; Work; addiction; base; driving force; graduate student; improved; insight; meetings; multidisciplinary; nervous system disorder; neural circuit; neuroregulation; novel strategies; optogenetics; public health relevance; symposium; synergism; translational neuroscience

 DESCRIPTION (provided by applicant): Summary This proposal requests R13 support for the founding meeting of the Gordon Research Conference (GRC) on Modulation of Neural Circuits and Behavior. Neural circuits control behavior, but these circuits are surprisingly plastic. Thus, neuromodulators can change the gain of circuits and even their function - biasing circuits to act in different modes. Scientists from diverse fields - biology, systems engineering, genetics, ethology, neurology and psychiatry - have increasingly recognized the central importance of neuromodulation for the control of behavior and the exciting links to translational neuroscience research. This inaugural GRC Conference is thus timely and unique because of its emphasis on attracting a multidisciplinary group of participants. The Conference will have a central galvanizing impact on the rapidly developing field of neuromodulation by bringing a new focus to the mechanism of action of dopamine, serotonin and various peptides and growth factors that have essential roles in regulating emotional and cognitive states. Defects in neuromodulatory pathways are increasingly implicated in multiple mental disorders, including depression, addiction and ADHD. Thus, a mechanistic understanding of the functional organization of modulatory circuits, the dynamics of modulatory signaling, the behavioral effects of various modulators, and the role of modulators in neuronal homeostasis, is essential for a fundamental understanding of brain function. Our conference is also unique because it will help bring together scientists from traditionally separate fields that explore the rich diversity of ecologicaly significant behaviors. Thus, the Conference will provide an opportunity for new synergisms between scientists working on modulation of neural circuits and behavior in vertebrate and invertebrate model systems. The meeting is particularly timely because the field of neuromodulation is ripe for transformative new approaches based on recent advances in genetic and optogenetic strategies for examining circuit function. Many of the recent advances in our understanding of neuromodulation have come from scientists in Australia, China, Japan, Korea and other Asian countries. Our conference will alternate between the United States and Hong Kong - ideal locations that will maximize the effectiveness of the Conference in promoting intensive exchange of ideas and techniques between American scientists and those from Europe and Asia. Thus, this GRC will be a driving force for emerging studies of neuromodulation in the United States. We expect that the 2015 GRC on Modulation of Neural Circuits and Behavior will shape future scientific directions and provide critical support for the mission of NIH, particularly NINDS and its sister institutes including NIMH, NIDA and NIA.

 描述（由申请人提供）：摘要本提案要求R13支持戈登研究会议（GRC）关于神经回路和行为调制的创始会议。神经回路控制行为，但这些回路令人惊讶地具有可塑性。因此，神经调制器可以改变电路的增益，甚至改变它们的功能-偏置电路以不同的模式起作用。来自不同领域的科学家-生物学，系统工程，遗传学，行为学，神经学和精神病学-越来越多地认识到神经调节对行为控制的核心重要性以及与转化神经科学研究的令人兴奋的联系。因此，首届GRC会议是及时和独特的，因为它强调吸引多学科的参与者。会议将对迅速发展的神经调节领域产生重要影响，使人们重新关注多巴胺、血清素和各种肽以及在调节情绪和认知状态方面发挥重要作用的生长因子的作用机制。神经调节通路的缺陷越来越多地涉及多种精神障碍，包括抑郁症，成瘾和ADHD。因此，对调节回路的功能组织、调节信号的动力学、各种调节剂的行为效应以及调节剂在神经元稳态中的作用的机械理解对于基本理解脑功能是必不可少的。我们的会议也是独一无二的，因为它将有助于汇集来自传统上不同领域的科学家，探索生态重要行为的丰富多样性。因此，会议将为从事脊椎动物和无脊椎动物模型系统中神经回路和行为调制的科学家之间的新协同作用提供机会。这次会议特别及时，因为神经调节领域已经成熟，可以采用基于遗传学和光遗传学策略最新进展的变革性新方法来检查电路功能。我们对神经调节的理解的许多最新进展来自澳大利亚，中国，日本，韩国和其他亚洲国家的科学家。我们的会议将轮流在美国和香港举行，这是一个理想的地点，可以最大限度地提高会议的效率，促进美国科学家与欧洲和亚洲科学家之间的思想和技术的深入交流。因此，这个GRC将成为美国新兴神经调节研究的推动力。我们预计2015年神经回路和行为调制研究报告将塑造未来的科学方向，并为NIH的使命提供关键支持，特别是NINDS及其姊妹机构，包括NIMH，NIDA和NIA。