UAB Core Center for Basic Skeletal Research (CCBSR)

UAB 基础骨骼研究核心中心 (CCBSR)

• 批准号: 7622629
• 负责人: Jay M. McDonald
• 金额: $ 56.51万
• 依托单位: UNIVERSITY OF ALABAMA AT BIRMINGHAM
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-05-01 至 2011-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7622629
• 关键词: UAB; Core; Center; Basic; Skeletal

DESCRIPTION (provided by applicant): This is a competitive renewal of The University of Alabama at Birmingham Core Center for Basic Skeletal Research (UAB CCBSR), Director: Jay M. McDonald, MD. The DAB CCBSR was founded to stimulate innovative, interdisciplinary approaches to the identification and characterization of the key mechanisms underlying bone loss and regeneration and the systemic and local factors that regulate these processes. The research base brings together 33 investigators with expertise in regulation of bone cell differentiation and function; cell-cell and cell-matrix interactions; and growth factor and hormonal regulation of bone cells and investigators with expertise in osteoporosis, periodontal disease, rheumatoid arthritis, bioengineering, and gene therapy. Progress during the first phase of funding (4 years) has been extraordinary: the funding base has increased to $12,654,831 in annual direct extramural bone-related funding; the CCBSR has supported over 250 bone-related publications; and a dynamic, collaborative research environment has been established. This progress can be attributed directly to the P30 funding: (1) the two research cores have supported 76 investigators; many having used both Cores, resulting in over 100 publications to date; and (2) the P&F program has supported 5 investigators who have obtained independent funding. This has facilitated recruitment of 7 new investigators in basic bone biology to UAB; a commitment of 43,000 net sq. ft. of new and renovated research space; and a multidisciplinary institutional commitment to hire 16 new bone biologists to UAB in the next four years. The infrastructure and Enrichment Programs of the Administrative Core have proven essential to the stimulation of innovative research targeting complex, multifactorial bone diseases, and have led to the rapid formation of new collaborative efforts as the research unfolds. The research cores, which are essential to the success of this dynamic program, include a: 1) Human Bone Cell Production Core providing human osteoclasts and osteoblasts and key reagents for molecular experimentation; 2) Histomorphometry and Molecular Analyses Core providing state-of-the-art histological, histomorphometric and highly sensitive cellular and tissue molecular probe techniques; and 3) Small Animal Bone Phenotyping Core providing comprehensive bone phenotyping by DEXA and micro CT. Three P&F studies have been competitively selected from 10 submissions: NFAT negatively regulates osteoblast differentiation and bone formation, M. Zayzafoon, MD, PhD; Role of hypoxia in bone formation, S. Gilbert, MD; and Mechanisms of oral bacteria-mediated bone resorption via toll-like receptors, H. Wu, PhD. The CCBSR has the potential to rapidly and significantly impact the prevention and treatment of osteoporosis and related bone diseases, as well as the development of more effective hard tissue implants through the basic and translational research necessary for the development of innovative therapeutic strategies.

描述(由申请人提供)： 这是阿拉巴马大学伯明翰分校基础骨骼研究核心中心(UAB CCBSR)的竞争性更新，主任：杰伊·M·麦克唐纳，医学博士。DAB CCBSR的建立是为了促进创新的、跨学科的方法，以识别和表征骨丢失和再生的关键机制以及调节这些过程的系统和局部因素。该研究基地汇集了33名在骨细胞分化和功能调节、细胞-细胞和细胞-基质相互作用、骨细胞生长因子和激素调节方面的专业研究人员，以及在骨质疏松症、牙周病、类风湿性关节炎、生物工程和基因治疗方面的专业研究人员。第一阶段资助(4年)的进展是非同寻常的：资助基数增加到12,654,831美元，每年与骨骼有关的直接外部资助；CCBSR支持了250多份与骨骼有关的出版物；并建立了一个充满活力和协作的研究环境。这一进展可以直接归功于P30的资助：(1)两个研究核心支持了76名调查人员；许多人同时使用了两个核心，导致迄今已发表了100多篇论文；(2)P&F计划支持了5名获得独立资助的调查人员。这为UAB招募了7名基础骨生物学的新研究人员提供了便利；承诺的净面积为43,000平方英尺。英国《金融时报》新的和翻新的研究空间；以及多学科机构承诺在未来四年内为UAB聘请16名新的骨生物学家。管理核心的基础设施和丰富计划已被证明对刺激针对复杂、多因素骨骼疾病的创新研究至关重要，并随着研究的展开迅速形成新的合作努力。对于这一动态计划的成功至关重要的研究核心包括：1)人类骨细胞生产核心，提供人类破骨细胞和成骨细胞以及分子实验的关键试剂；2)组织形态计量学和分子分析核心，提供最先进的组织学、组织形态计量学和高灵敏度的细胞和组织分子探针技术；以及3)小动物骨表型核心，提供DEXA和Micro CT的全面骨表型分析。从10篇投稿中竞争性地选出了三篇P&F研究：NFAT对成骨细胞分化和骨形成的负面调节，M.Zayzafoon，MD，PhD；缺氧在骨形成中的作用，S.Gilbert，MD；以及口腔细菌通过Toll样受体介导的骨吸收的机制，H.Wu，PhD。CCBSR有可能通过开发创新治疗策略所需的基础和翻译研究，迅速和显著地影响骨质疏松症和相关骨骼疾病的预防和治疗，以及更有效的硬组织植入物的开发。