EMA and Lab Assessment of Nicotine Dependence among Dual ENDS Users

描述（由申请人提供）：我的主要职业目标是成为烟草产品特性如何使用新的实验室，调查和定性方法影响烟草使用行为的专家。我获得烟草控制监管研究K01职业发展奖的目标是获得培训，研究产品特性，即烟草产品滥用责任和吸引力，如何影响烟草使用行为。为了获得这些知识和必要的研究技能，我建议通过专注于成瘾行为药理学和人类实验室研究方法的研究进行导师制，教学培训和体验式学习。拟议的研究将通过确定雪茄样和笔样ECIG对ECIG实验和随后的烟草吸烟行为的初始差异效应，为FDA烟草监管做出贡献。据我们所知，这将是第一项结合联合收割机临床实验室和吸烟者ECIG实验真实世界数据收集的研究，也是第一项明确比较两种主要ECIG器械类型效果的研究。结果将直接解决ECIG滥用倾向，尼古丁暴露和加强疗效的问题。这项研究也将开始必要的工作，以了解ECIG可用性对随后的烟草戒烟尝试的影响。这项研究将是我第一次使用人类实验室方法收集原始数据，以及我对烟草滥用责任和上诉对烟草使用行为的影响的应用。此外，这项研究将补充和扩展我的同步社会和行为研究的规范和危害认知的影响ECIG实验和燃烧烟草的使用。 雷Niaura和汤姆·罗森伯格）谁是致力于我的培训，并相信我提出的研究的重要性，以及强大的机构支持施罗德研究所，我准备发展成为一个独立的和高效的研究调查。这个职业发展奖将使我能够把75%的时间投入到行为药理学的教学培训中，发展临床实验室方法的专业知识培训，以补充我在调查研究方面的技能，并撰写R01研究提案，以启动我作为烟草监管科学独立调查员的职业生涯。

DESCRIPTION (provided by applicant): My principal career goal is to become an expert in how tobacco product characteristics influence tobacco use behavior using novel laboratory, survey, and qualitative methodologies. My goal for this K01 Career Development Award in Tobacco Control Regulatory Research is to obtain the training to research how product characteristics, namely tobacco product abuse liability and appeal, affect tobacco use behavior. To gain this knowledge and requisite research skills, I propose mentorship, didactic training, and experiential learning through research focused on the behavioral pharmacology of addiction and human laboratory research methods. The proposed research will contribute to FDA tobacco regulation by identifying the initial differential effects of ciga-like and pen-like ECIGs on ECIG experimentation and subsequent tobacco cigarette smoking behavior. To our knowledge, this will be the first study to combine clinical laboratory and real-world data collection of ECIG experimentation in smokers, as well as the first to compare explicitly the effect of the two major ECIG device types. Results will directly address the issues of ECIG abuse liability, nicotine exposure, and reinforcing efficacy. This research will also begin the work necessary to understand the effect of ECIG availability on subsequent tobacco cigarette smoking quit attempts. This study will be my first experience with primary data collection using human lab methods and my application of the effect of tobacco abuse liability and appeal on tobacco use behavior. Additionally, this research will compliment and expand upon my concurrent social and behavioral research on the impact of norms and harm perceptions on ECIG experimentation and combusted tobacco use. With outstanding mentors (Drs. Ray Niaura and Tom Eissenberg) who are committed to my training and believe in the importance of my proposed research, as well as strong institutional support from the Schroeder Institute, I am poised to develop into an independent and highly productive research investigator. This Career Development Award would enable me to devote 75% of my time to didactic training in behavioral pharmacology, develop expertise training in clinical laboratory methods to complement my skills in survey research, and write an R01 research proposals to launch my career as an independent investigator in tobacco regulatory science.