Administrative Core

IgE介导的食物过敏的患病率在过去20年中有所增加， 影响了3.5%到4%的美国人口，仅花生过敏，这是唯一的主要原因， 在美国，严重和致命的食物引起的过敏反应影响了150万美国人， 在过去十年中，幼儿的发病率。这种增长的原因尚不清楚，但很明显， 目前预防花生过敏和严重过敏反应的策略 意外摄入花生后的效果并不明显。同样，嗜酸性粒细胞性食管炎（EE），主要是 一种儿童食物过敏性疾病，患病率增加，其潜在机制是 人们对此知之甚少，预防和治疗工作也不能令人满意。 五年前，一个由五所大学的调查人员组成的联合会成立， IgE介导的牛奶、鸡蛋和花生过敏的自然史和潜在免疫机制， 并检测新型重组花生蛋白疫苗EMP-123的效力。为了实现 为了实现这些目标，建立了一个明确的行政结构。尽管生产问题 延迟EMP-123的可用性，行政核心能够有效地指导观测 研究并启动了3项免疫试验。在这里提出的扩大财团中， 行政核心将继续协调和促进研究中心、NIAID和 SACC，并优化研究与自然免疫相关的基本免疫机制的努力。 在我们完善的队列中有食物过敏史，完成正在进行的花生SLIT试验，并评估 两种额外治疗策略的疗效。随着一个新网站的增加，行政核心 将直接努力调查食物过敏在EE中的作用，比较和对比自然史， EE的免疫学和遗传学标记与IgE介导的食物过敏的标记。 这个新的联合体有着成功的记录， 这是一个独特的机会来解决这些成长性疾病的潜在基础。

The prevalence of IgE-mediated food allergy has increased over the past 2 decades and food allergy now affects 3.5% to 4% of the U.S. population, and peanut allergy alone, which is the single leading cause of severe and fatal food-induced allergic reactions in the US, affects 1.5 million Americans and has doubled in prevalence in young children in the past decade. The reasons for this increase are unknown, but it is clear that current strategies for preventing the development of peanut allergy and the severe allergic reactions following accidental ingestion of peanuts are not effective. Similarly, eosinophilic esophagitis (EE), primarily a food hypersensitivity disorder in children, has increased in prevalence, its underlying mechanisms are poorly understood and efforts at prevention and treatment are unsatisfactory. Five years ago a Consortium consisting of investigators from five universities was formed to investigate the natural history and underlying immunologic mechanisms of IgE-mediated milk, egg and peanut allergy, and to test the efficacy of a novel recombinant peanut protein vaccine, EMP-123. In order to accomplish these objectives, a well-defined administrative structure was established. Although production issues delayed the availability of EMP-123, the Administrative Core was able to effectively directe the observational study and initiated 3 immunotherapeutic trials. In the expanded Consortium proposed here, the Administrative Core will continue to coordinate and facilitate interactions between study sites, the NIAID and SACC, and to optimize efforts to investigate basic immunologic mechanisms associated with the natural history of food allergy in our well established cohort, complete a Peanut SLIT trial underway, and evaluate the efficacy of two additional therapeutic strategies. With the addition of a new site, the Administrative Core will direct efforts to investigate the role of food allergy in EE, comparing and contrasting the natural history and immunologic and genetic markers of EE with those of IgE-mediated food allergy. With its demonstrated record of success, the combined resources of this new Consortium provide a unique opportunity to address the underlying basis of these growing disorders.