Center for Natural Product Technologies at UIC (CeNAPT)

 描述（由申请人提供）：根据RFA-AT-14-006，推进天然产品创新和技术中心（CANPIT）的更大目标是开发、巩固和传播技术，以克服天然产品（NP）研究中的方法障碍，并在CANPIT、外部专家和合作的主要NP研究者之间建立协同互动。为了满足这一需求，拟议的UIC CANPIT整合了三个多学科技术研究与开发（TR&D）项目，由一个研究团队运营，在NP研究方面具有良好的合作，创新和卓越的记录。UIC CANPIT将开发并积极分享尖端的生物分析方法，以解决重要的生物医学问题，并推进NP药物及其代谢组学复杂性的整体方法。方法学的改进将解决翻译NP研究的持续需求：靶向和可重复的分离（TR&D项目1），通用纯度分析，先进的结构去复制和测定（TR&D项目2），以及靶向高灵敏度检测和定量NP及其药代动力学代谢物（TR&D项目3）。UIC CANPIT的生物分析重点与RFA中确定的大多数（8个中的6个）“特定研究领域”相匹配。此外，这一重点反映了丰富的初步数据和来自UIC团队的众多创新NP技术的可用性，并准备进行调整，合作和传播。因此，项目1/2/3具有假设驱动和共享驱动的目标，旨在开发、巩固和调整尖端的NP方法。共享机制（“适应和/或开发共享”）的计划特点的CANPIT技术和建议的合作研究与9个外部技术示范项目（TDPs）的地位。除了协调CANPIT-TDP的相互作用，协调与传播（C&D）项目的目标是协调UIC CANPIT的研究成果，挖掘生物分析NP知识，为NP制作良好研究实践（GRP）文件，并促进CANPIT成果的一致性。一个行政和管理（A&M）核心将管理中心的会议和报告功能，并协调内部和外部的资源和关系。UIC CANPIT将获得大量的机构和外部支持，如20封支持信所述。PI/PD及其团队与指定的NCCAM科学家和外部咨询委员会密切合作，通过生物分析创新和积极分享，以克服天然产物社区目前面临的方法学障碍，寻求实现建立NP研究方法学领导地位的最终目标。

 DESCRIPTION (provided by applicant): According to RFA-AT-14-006, the greater objective of a Center for Advancing Natural Products Innovation and Technology (CANPIT) is to develop, consolidate, and disseminate technologies in order to overcome methodological obstacles in natural products (NP) research, and to establish synergistic interaction between the CANPIT, external experts, and collaborating leading NP investigators. Addressing this demand, the proposed UIC CANPIT integrates three multidisciplinary Technology Research & Development (TR&D) Projects operated by an investigator team with a strong record of collaboration, innovation, and excellence in NP research. The UIC CANPIT will develop, and actively share, cutting edge bioanalytical methodologies that address important biomedical questions and advance the holistic approach to NP agents and their metabolomic complexity. The methodological improvements will address persistent needs in translational NP research: targeted and reproducible separation (TR&D Project 1), universal purity analysis, advanced structure de-replication and determination (TR&D Project 2), as well as targeted high-sensitivity detection and quantification of NPs and their pharmacokinetic metabolites (TR&D Project 3). The bioanalytical focus of the UIC CANPIT matches the majority (6 of 8) of the "Specific Areas of Research Interest" identified in the RFA. Moreover, this focus reflects the wealth of preliminary data and the availability of numerous innovative NP technologies that originate from the UIC team and are ready for adaptation, collaboration, and dissemination. Accordingly, the Projects 1/2/3 have both hypothesis- and sharing-driven aims that seek to develop, consolidate, and adapt cutting edge NP methodologies. Plans for sharing mechanisms ("adapt- and/or develop-to-share") feature the status of the CANPIT technology and proposals for collaborative research with nine outside Technology Demonstration Projects (TDPs) are presented. In addition to coordinating the CANPIT-TDP interactions, the objective of the Coordination & Dissemination (C&D) Project is to harmonize the research output of the UIC CANPIT, mine bioanalytical NP knowledge, produce Good Research Practices (GRPs) documentation for NPs, and promote the coherence of the CANPIT outcomes. An Administrative & Management (A&M) Core will manage the center's meeting and reporting functions and coordinate the intra- and extramural resources and relationships. The UIC CANPIT will receive substantial institutional and outside support as documented in 20 support letters. Working closely with the assigned NCCAM scientist and the External Advisory Committee, the PI/PD and his team seek to achieve the ultimate objective of establishing leadership in NP research methodology through bioanalytical innovation and active sharing in order to overcome the methodological hurdles currently faced by the natural products community.