Center for Natural Product Technologies at UIC (CeNAPT)

 描述(由申请人提供)：根据RFA-AT-14-006，天然产品创新与技术促进中心(CANPIT)的更大目标是开发、巩固和传播技术，以克服天然产品(NP)研究中的方法学障碍，并在CANPIT、外部专家和协作的NP领先调查人员之间建立协同互动。为了满足这一需求，拟议的UIC CANPIT整合了三个多学科技术研究与开发(TR&D)项目，由一个在NP研究方面具有良好的合作、创新和卓越记录的研究团队运营。UIC CANPIT将开发并积极分享尖端生物分析方法，以解决重要的生物医学问题，并推动研究NP制剂及其代谢组复杂性的整体方法。方法学上的改进将满足翻译NP研究中的长期需求：有针对性和可重复的分离(TR&D项目1)、普遍纯度分析、先进的结构去复制和测定(TR&D项目2)，以及有针对性的高灵敏度检测和量化NPs及其药代动力学代谢物(TR&D项目3)。UIC CANPIT的生物分析重点与RFA中确定的大多数(8个中的6个)“特定研究领域”相匹配。此外，这一重点反映了丰富的初步数据和许多创新的国家方案技术的可获得性，这些技术源自UIC小组，并已准备好进行适应、协作和传播。因此，1/2/3的项目既有假设驱动的目标，也有共享驱动的目标，即寻求开发、巩固和适应尖端的NP方法。提出了以CANPIT技术现状为特色的共享机制(“适应-和/或开发-共享”)计划，并提出了与9个外部技术示范项目(TDP)合作研究的建议。协调与传播(C&D)项目的目标除了协调非洲核科技中心-TDP之间的互动外，还旨在协调该中心的研究成果，挖掘生物分析核计划知识，为核计划编制良好的研究实践(GRP)文件，并促进核不扩散核技术成果的一致性。行政和管理(A&M)核心将管理中心的会议和报告职能，并协调内部和外部资源和关系。如20封支持信所述，UIC CANPIT将得到大量的机构和外部支持。与指定的NCCAM科学家和外部咨询委员会密切合作，PI/PD及其团队寻求通过生物分析创新和积极分享实现在NP研究方法方面建立领导地位的最终目标，以克服天然产品界目前面临的方法障碍。

 DESCRIPTION (provided by applicant): According to RFA-AT-14-006, the greater objective of a Center for Advancing Natural Products Innovation and Technology (CANPIT) is to develop, consolidate, and disseminate technologies in order to overcome methodological obstacles in natural products (NP) research, and to establish synergistic interaction between the CANPIT, external experts, and collaborating leading NP investigators. Addressing this demand, the proposed UIC CANPIT integrates three multidisciplinary Technology Research & Development (TR&D) Projects operated by an investigator team with a strong record of collaboration, innovation, and excellence in NP research. The UIC CANPIT will develop, and actively share, cutting edge bioanalytical methodologies that address important biomedical questions and advance the holistic approach to NP agents and their metabolomic complexity. The methodological improvements will address persistent needs in translational NP research: targeted and reproducible separation (TR&D Project 1), universal purity analysis, advanced structure de-replication and determination (TR&D Project 2), as well as targeted high-sensitivity detection and quantification of NPs and their pharmacokinetic metabolites (TR&D Project 3). The bioanalytical focus of the UIC CANPIT matches the majority (6 of 8) of the "Specific Areas of Research Interest" identified in the RFA. Moreover, this focus reflects the wealth of preliminary data and the availability of numerous innovative NP technologies that originate from the UIC team and are ready for adaptation, collaboration, and dissemination. Accordingly, the Projects 1/2/3 have both hypothesis- and sharing-driven aims that seek to develop, consolidate, and adapt cutting edge NP methodologies. Plans for sharing mechanisms ("adapt- and/or develop-to-share") feature the status of the CANPIT technology and proposals for collaborative research with nine outside Technology Demonstration Projects (TDPs) are presented. In addition to coordinating the CANPIT-TDP interactions, the objective of the Coordination & Dissemination (C&D) Project is to harmonize the research output of the UIC CANPIT, mine bioanalytical NP knowledge, produce Good Research Practices (GRPs) documentation for NPs, and promote the coherence of the CANPIT outcomes. An Administrative & Management (A&M) Core will manage the center's meeting and reporting functions and coordinate the intra- and extramural resources and relationships. The UIC CANPIT will receive substantial institutional and outside support as documented in 20 support letters. Working closely with the assigned NCCAM scientist and the External Advisory Committee, the PI/PD and his team seek to achieve the ultimate objective of establishing leadership in NP research methodology through bioanalytical innovation and active sharing in order to overcome the methodological hurdles currently faced by the natural products community.