FASEB SRC on Helicases and Nucleic-Acid Based Machines: From Mechanism to Insights into Disease

FASEB SRC 关于解旋酶和核酸机器：从机制到洞察疾病

• 批准号: 8986287
• 负责人: Maria Spies
• 金额: $ 0.5万
• 依托单位: FEDERATION OF AMER SOC FOR EXPER BIOLOGY
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-07-15 至 2016-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8986287
• 关键词: Address; Advertising; Aging; American; Area; Award; Biological Preservation; Biology; Biophysics; Bloom Syndrome; California; Caring; Cell division; Cell physiology; Cells; Chemistry; Child; Cities; Cockayne Syndrome; Colorado; Complex; DNA biosynthesis; Data; Defect; Development; Diagnosis; Disabled Persons; Disease; Electronic Mail; Environment; Enzymes; Family; Fanconi' s Anemia; Fees; Female; Foundations; Gene Expression; Gene Expression Regulation; Genetic; Genetic Materials; Genomic Instability; Growth; Health; Housing; Human; Immunodeficiency and Cancer; Immunologic Deficiency Syndromes; Information Technology; Inherited; Iowa; Journals; Knowledge; Longevity; Malignant Neoplasms; Metabolism; Minority; Molecular; Molecular Machines; Molecular Structure; Nature; Newsletter; Nucleic Acids; Nucleoproteins; Participant; Play; Pluripotent Stem Cells; Predisposition; Premature aging syndrome; Process; Proteins; Publishing; RNA; RNA Helicase; RNA Processing; Recording of previous events; Regulation; Request for Applications; Research; Research Personnel; Resort; Resources; Role; Science; Scientific Societies; Scientist; Site; Societies; Speed; Structure; Switzerland; System; Time; Trichothiodystrophy; Underrepresented Minority; Universities; Werner Syndrome; Woman; Xeroderma Pigmentosum; base; chromatin remodeling; ds-DNA; experience; graduate student; grasp; helicase; human disease; improved; innovation; insight; interest; malignant breast neoplasm; meetings; nervous system disorder; nucleic acid metabolism; posters; programs; public health relevance; recombinational repair; segregation; single molecule; structural biology; success; symposium; translocase

 DESCRIPTION (provided by applicant): This application requests support for the 2015 summer research conference on "Helicases and Nucleic- Acid Based Machines: From Mechanism to Insight into Disease". The meeting is sponsored by the Federation of American Societies for Experimental Biology (FASEB) and will take place from July 26-31, 2015, in Steamboat Springs, Colorado. The conference organizers are Maria Spies (University of Iowa, Iowa City, USA) and Karsten Weis (University of California, Berkeley, USA, and ETH Zurich, Switzerland). Due to their capacity to unwind structures of double-stranded DNA and RNA, and to remodel nucleoprotein complexes, helicases and helicase-like translocases are critical components of numerous nucleic acid processing machines. Consequently, their activities are obligatory to all cellular information transactions and defects in these enzymes are associated with a broad spectrum of human diseases including cancer and premature aging. In recent years, the field has developed a first grasp of the basic mechano-chemistry and general structural organization of both RNA- and DNA helicases. Furthermore, we have come to appreciate the importance of these enzymes for many fundamental cellular processes. The development and application of many cutting edge experimental approaches ranging from structural biology and single- molecule biophysics to manipulation of pluripotent stem cells for the study of these systems attend to this fact. The critical roles of helicases in the regulation o DNA replication, repair, recombination and gene expression and their dysregulation in many diseases, combined with the breadth of the experimental approaches applied to helicases has created a growing need for an exchange of information among the diverse group of scientists studying the helicase structure, regulation, molecular and cellular functions, and disease-processes associated with defects in or dysregulation of these enzymes. To address this need, the ninth bi-annual meeting on Helicases and Nucleic-Acid Based Machines aims at expanding the helicases related research. It will promote the information exchange among experienced and young investigators studying RNA and DNA helicases and helicase-like translocases, and will integrate the knowledge obtained through a broad range of experimental strategies. The meeting will focus on understanding the regulation of these enzymes, how they fit into supramolecular machines of the cell, and how the knowledge of their structures and mechanisms can be exploited to improve human health. The FASEB conference format combines an optimally sized meeting (approximately 150 participants) with an environment that promotes continuous formal and informal interactions between the participants. It will allow us to emphasize truly exceptional research and provide opportunities for the exchange of information, technology and perspective on helicases and helicase-like translocases.

 申请者描述(申请人提供)：本申请请求支持2015年夏季“解旋酶和基于核酸的机器：从机制到疾病洞察”的研究会议。这次会议由美国实验生物学学会联合会(FASE B)主办，将于2015年7月26日至31日在科罗拉多州的蒸汽船斯普林斯举行。会议的组织者是玛丽亚·斯皮斯(美国爱荷华大学，爱荷华市)和卡斯滕·韦斯(美国加州大学伯克利分校和瑞士苏黎世理工大学)。解旋酶和解旋酶样转位酶具有解离双链DNA和RNA结构和改造核蛋白复合体的能力，是许多核酸加工机器的关键部件。因此，它们的活动是所有细胞信息交易的必备条件，这些酶的缺陷与包括癌症和早衰在内的一系列人类疾病有关。近年来，该领域对RNA和DNA解旋酶的基本机械力化学和一般结构组织有了初步的了解。此外，我们已经认识到这些酶对许多基本的细胞过程的重要性。许多尖端实验方法的发展和应用，从结构生物学和单分子生物物理学，到操纵多能干细胞来研究这些系统，都符合这一事实。解旋酶在调节DNA复制、修复、重组和基因表达中的关键作用以及它们在许多疾病中的失调，加上应用于解旋酶的各种实验方法的广泛性，使得研究解旋酶的结构、调控、分子和细胞功能以及与这些酶的缺陷或失调相关的疾病过程的不同科学家之间的信息交流的需求越来越大。为了满足这一需要，第九届解旋酶和基于核酸的机器双年度会议旨在扩大解旋酶的相关研究。它将促进研究RNA和DNA解旋酶以及类似解旋酶的转位酶的有经验的年轻研究人员之间的信息交流，并将整合通过广泛的实验战略获得的知识。会议将重点了解这些酶的调节，它们如何适应细胞的超分子机器，以及如何利用对其结构和机制的知识来改善人类健康。FASEB会议形式将最佳规模的会议(约150名与会者)与促进与会者之间持续的正式和非正式互动的环境结合在一起。它将使我们能够强调真正特殊的研究，并为交流关于解旋酶和解旋酶样易位的信息、技术和观点提供机会。