FASEB SRC on Helicases and Nucleic-Acid Based Machines: From Mechanism to Insights into Disease

 描述（由申请人提供）：本申请请求支持2015年夏季研究会议“解旋酶和基于核酸的机器：从机制到洞察疾病”。会议由美国实验生物学学会联合会（FASEB）主办，将于2015年7月26日至31日在科罗拉多的汽船泉举行。会议组织者是Maria Spies（爱荷华州大学，爱荷华州市，美国）和Karsten Weis（加州大学，伯克利，美国和ETH苏黎世，瑞士）。 由于解旋酶和解旋酶样易位酶能够解旋双链DNA和RNA的结构，并重塑核蛋白复合物，因此它们是许多核酸加工机器的关键组分。因此，它们的活性对所有细胞信息交易都是必需的，这些酶的缺陷与包括癌症和过早衰老在内的广泛的人类疾病有关。近年来，该领域已经发展了一个基本的机械化学和RNA和DNA解旋酶的一般结构组织的第一次掌握。此外，我们已经认识到这些酶对许多基本细胞过程的重要性。从结构生物学和单分子生物物理学到操纵多能干细胞研究这些系统的许多尖端实验方法的开发和应用都涉及到这一事实。解旋酶在调节DNA复制、修复、重组和基因表达及其在许多疾病中的失调中的关键作用，结合应用于解旋酶的实验方法的广度，已经产生了对研究解旋酶结构、调节、分子和细胞功能的不同科学家群体之间的信息交换的日益增长的需求，以及与这些酶的缺陷或失调相关的疾病过程。为了满足这一需求，第九届解旋酶和基于核酸的机器会议旨在扩大解旋酶相关的研究。它将促进研究RNA和DNA解旋酶和解旋酶样易位酶的有经验和年轻的研究人员之间的信息交流，并将整合通过广泛的实验策略获得的知识。会议将侧重于了解这些酶的调节，它们如何适应细胞的超分子机器，以及如何利用其结构和机制的知识来改善人类健康。FASEB会议形式将最佳规模的会议（约150名与会者）与促进与会者之间持续的正式和非正式互动的环境相结合。它将使我们能够强调真正卓越的研究，并为解旋酶和解旋酶样易位酶的信息，技术和观点的交流提供机会。

 DESCRIPTION (provided by applicant): This application requests support for the 2015 summer research conference on "Helicases and Nucleic- Acid Based Machines: From Mechanism to Insight into Disease". The meeting is sponsored by the Federation of American Societies for Experimental Biology (FASEB) and will take place from July 26-31, 2015, in Steamboat Springs, Colorado. The conference organizers are Maria Spies (University of Iowa, Iowa City, USA) and Karsten Weis (University of California, Berkeley, USA, and ETH Zurich, Switzerland). Due to their capacity to unwind structures of double-stranded DNA and RNA, and to remodel nucleoprotein complexes, helicases and helicase-like translocases are critical components of numerous nucleic acid processing machines. Consequently, their activities are obligatory to all cellular information transactions and defects in these enzymes are associated with a broad spectrum of human diseases including cancer and premature aging. In recent years, the field has developed a first grasp of the basic mechano-chemistry and general structural organization of both RNA- and DNA helicases. Furthermore, we have come to appreciate the importance of these enzymes for many fundamental cellular processes. The development and application of many cutting edge experimental approaches ranging from structural biology and single- molecule biophysics to manipulation of pluripotent stem cells for the study of these systems attend to this fact. The critical roles of helicases in the regulation o DNA replication, repair, recombination and gene expression and their dysregulation in many diseases, combined with the breadth of the experimental approaches applied to helicases has created a growing need for an exchange of information among the diverse group of scientists studying the helicase structure, regulation, molecular and cellular functions, and disease-processes associated with defects in or dysregulation of these enzymes. To address this need, the ninth bi-annual meeting on Helicases and Nucleic-Acid Based Machines aims at expanding the helicases related research. It will promote the information exchange among experienced and young investigators studying RNA and DNA helicases and helicase-like translocases, and will integrate the knowledge obtained through a broad range of experimental strategies. The meeting will focus on understanding the regulation of these enzymes, how they fit into supramolecular machines of the cell, and how the knowledge of their structures and mechanisms can be exploited to improve human health. The FASEB conference format combines an optimally sized meeting (approximately 150 participants) with an environment that promotes continuous formal and informal interactions between the participants. It will allow us to emphasize truly exceptional research and provide opportunities for the exchange of information, technology and perspective on helicases and helicase-like translocases.