Pulmonary Diseases in WTC Workers: Symptoms, Function, and Chest CT Correlates

世贸中心工作人员的肺部疾病：症状、功能和胸部 CT 相关性

• 批准号: 8857385
• 负责人: Rafael E. de la Hoz
• 金额: $ 82.99万
• 依托单位: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-09-01 至 2017-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8857385
• 关键词: Pulmonary; Diseases; WTC; Workers; Symptoms

DESCRIPTION (provided by applicant): The overall goals of this proposal are to identify the early manifestations of lung disease among the WTC workers and volunteers, as well as investigate their risk factors. To accomplish this, we will perform standardized and computer-assisted readings of all the chest CT scans performed at Mount Sinai Medical Center on these workers since January 2003, assess the findings in a systematic way, evaluate the correlation of findings with clinical, functional, and exposure indicators, and develop a protocol for continued radiological surveillance of this cohort. In order to validate the findings from the chest CT scans obtained from 2002-2011 (2870 studies in 1710 workers), we will prospectively perform paired inspiratory-expiratory, low- dose, gated CT scans and spirometry on a set of 800 participants over the 4 years of the grant, to determine the prevalence of lung cancer, emphysema, fibrotic and Interstitial lung disease, small airways disease (including air trapping). We will select individuals for whom there would not be a clinical indication to test some of the secondary hypotheses, to update a previous study, and to allow case-control studies with the retrospective cases (most of whom had respiratory symptoms, spirometric abnormalities, or chest radiographic abnormalities, or any combination thereof).

描述（由申请人提供）：该提案的总体目标是确定WTC工人和志愿者中肺部疾病的早期表现，并调查其危险因素。为此，我们将对自2003年1月以来在Sinai Medical Center上进行的所有胸部CT扫描进行标准化和计算机辅助读数，以系统的方式评估发现，评估发现与临床，功能和暴露指示器的相关性，并为该群体的持续悬念性监测提供协议。为了验证胸部CT扫描的发现 从2002 - 2011年获得（在1710名工人中进行的2870项研究），我们将在赠款的4年中对一组800名参与者进行配对的吸气，低剂量的，低剂量的CT扫描和肺活量测定，以确定肺癌的普遍存在，肺癌，肺气肿，纤维化和肠道肺部疾病，包括空中疾病（包括空中疾病）。我们将选择没有临床指示的人来检验某些次要假设，更新先前的研究，并允许病例对照研究（大多数人都有呼吸症状，肺部异常或胸部放射学异常或任何组合）。