Chronic Obstructive Pulmonary Disase in WTC Workers - Diagnoses and Transitions

世贸中心工作人员的慢性阻塞性肺疾病 - 诊断和转变

• 批准号: 10749523
• 负责人: Rafael E. de la Hoz
• 金额: $ 49.68万
• 依托单位: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-07-01 至 2026-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10749523
• 关键词: Chronic; Obstructive; Pulmonary; Disase; WTC

Project Summary Our long-term goal has been to characterize the heterogeneous group of chronic lower airway diseases (LAD) observed in World Trade Center (WTC) workers and volunteers, uncover their risk factors and comorbidities, identify subgroups with adverse and favorable lung function trajectories and outcomes, and develop and deploy novel imaging approaches to the investigation of the lung injury underlying them. Such goal will in turn translate into better understanding of disease pathophysiology, more targeted, personalized, and perhaps disease modifying treatment approaches, and improved surveillance and prevention strategies. The goal of this project has been to characterize the transitions into chronic obstructive pulmonary disease (COPD) among former workers and volunteers at the WTC disaster site. Following our objective characterization of our COPD cases, our multidisciplinary investigative team proposes to establish the quantitative computed tomography (QCT) characteristics that may differentiate WTC-related from non- WTC-related COPD, investigate characteristics and longitudinal lung function trajectories of WTC patients with pre-COPD, and investigate lung mechanical strain (LMS) as an early QCT marker of lung injury associated with chronic disease and accelerated longitudinal lung function decline. This project will be conducted in the occupational cohort followed at Mount Sinai. To that end, we will utilize the WTC Pulmonary Evaluation Unit Chest CT Imaging Archive, a large repository with more than 3000 chest CT images on 1700 WTC workers, as well as linked datasets with disease symptoms, both pre- WTC and WTC-related occupational exposures, detailed pulmonary function and longitudinal spirometry measurements and body weight trends, visual imaging classification and grading, and quantitative computer tomography (QCT) measurements of airway, body composition, and pulmonary parenchymal and vascular abnormalities.

项目概要 我们的长期目标是描述慢性下呼吸道异质组的特征 在世界贸易中心 (WTC) 工作人员和志愿者中观察到的疾病 (LAD)，揭示他们的风险因素并 合并症，确定具有不利和有利肺功能轨迹和结果的亚组，以及 开发和部署新的成像方法来调查其潜在的肺损伤。这样的 目标将反过来转化为对疾病病理生理学的更好理解，更有针对性， 个性化的、也许是改变疾病的治疗方法，以及改进的监测和 预防策略。 该项目的目标是描述慢性阻塞性肺疾病的转变特征 世贸中心灾难现场的前工人和志愿者中患有慢性阻塞性肺病 (COPD)。遵循我们的目标 根据我们的慢性阻塞性肺病病例的特征，我们的多学科调查团队建议建立 定量计算机断层扫描 (QCT) 特征可将 WTC 相关与非 WTC 相关的特征区分开来 WTC 相关 COPD，调查 WTC 患者的特征和纵向肺功能轨迹 患有慢性阻塞性肺疾病 (COPD) 前期，并研究肺机械应变 (LMS) 作为肺损伤的早期 QCT 标志物 与慢性疾病和加速纵向肺功能下降有关。 该项目将在西奈山的职业队列中进行。为此，我们 将利用 WTC 肺部评估单元胸部 CT 成像档案，这是一个大型存储库，包含超过 1700 名世贸中心工作人员的 3000 张胸部 CT 图像，以及带有疾病症状的链接数据集，均是在 WTC 和 WTC 相关职业暴露、详细肺功能和纵向肺活量测定 测量和体重趋势、视觉成像分类和分级、定量计算机 气道、身体成分、肺实质和血管的断层扫描 (QCT) 测量 异常。

项目成果

Occupational lung disease: when should I think of it and why is it important?

• DOI: 10.1183/20734735.0002-2023
• 发表时间: 2023-06
• 期刊: Breathe (Sheffield, England)

World Trade Center Health Program best practices for diagnosing and treating chronic obstructive pulmonary disease.

世界贸易中心健康计划诊断和治疗慢性阻塞性肺病的最佳实践。

• DOI: 10.1080/19338244.2022.2146040
• 发表时间: 2023
• 期刊: Archives of environmental & occupational health
• 影响因子: 1.8
• 作者: Cone,JamesE;delaHoz,RafaelE
• 通讯作者: delaHoz,RafaelE