Pulmonary Diseases in WTC Workers: Symptoms, Function, and Chest CT Correlates

世贸中心工作人员的肺部疾病：症状、功能和胸部 CT 相关性

• 批准号: 8471556
• 负责人: Rafael E. de la Hoz
• 金额: $ 88.52万
• 依托单位: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-09-01 至 2016-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8471556
• 关键词: Pulmonary; Diseases; WTC; Workers; Symptoms

DESCRIPTION (provided by applicant): The overall goals of this proposal are to identify the early manifestations of lung disease among the WTC workers and volunteers, as well as investigate their risk factors. To accomplish this, we will perform standardized and computer-assisted readings of all the chest CT scans performed at Mount Sinai Medical Center on these workers since January 2003, assess the findings in a systematic way, evaluate the correlation of findings with clinical, functional, and exposure indicators, and develop a protocol for continued radiological surveillance of this cohort. In order to validate the findings from the chest CT scans obtained from 2002-2011 (2870 studies in 1710 workers), we will prospectively perform paired inspiratory-expiratory, low- dose, gated CT scans and spirometry on a set of 800 participants over the 4 years of the grant, to determine the prevalence of lung cancer, emphysema, fibrotic and Interstitial lung disease, small airways disease (including air trapping). We will select individuals for whom there would not be a clinical indication to test some of the secondary hypotheses, to update a previous study, and to allow case-control studies with the retrospective cases (most of whom had respiratory symptoms, spirometric abnormalities, or chest radiographic abnormalities, or any combination thereof). PUBLIC HEALTH RELEVANCE: This study will evaluate all chest CT scans performed on the former WTC workers since 2003, to investigate the manifestations of pulmonary diseases, even if subtle, and establish a method to follow these workers prospectively.

描述(由申请人提供)：这项提案的总体目标是确定WTC工作人员和志愿者中肺部疾病的早期表现，并调查他们的危险因素。为了实现这一目标，我们将对自2003年1月以来在西奈山医疗中心对这些工人进行的所有胸部CT扫描进行标准化和计算机辅助读取，以系统的方式评估结果，评估结果与临床、功能和暴露指标的相关性，并制定对该队列进行持续放射监测的方案。为了验证胸部CT扫描的发现 通过2002-2011年间的研究(1710名工人中的2870项研究)，我们将在4年的拨款中对800名参与者进行成对的吸气-呼气、低剂量门控CT扫描和肺活量测定，以确定肺癌、肺气肿、纤维化和间质性肺疾病、小气道疾病(包括空气滞留)的患病率。我们将选择没有临床指征的个体来检验一些次级假设，更新先前的研究，并允许对回顾病例进行病例对照研究(他们中的大多数有呼吸道症状、肺活量异常或胸部X光异常，或它们的任何组合)。 公共卫生相关性：这项研究将评估自2003年以来对前WTC工作人员进行的所有胸部CT扫描，以调查肺部疾病的表现，即使是细微的，并建立一种方法来前瞻性地跟踪这些工作人员。