Hair Cortisol as a Biomarker of Chronic Early Life Stress
头发皮质醇作为慢性早期生活压力的生物标志物
基本信息
- 批准号:8807044
- 负责人:
- 金额:$ 8.89万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2015
- 资助国家:美国
- 起止时间:2015-04-01 至 2017-03-31
- 项目状态:已结题
- 来源:
- 关键词:1 year old2 year oldAcuteAddressAdrenal GlandsAdultAgeArea Under CurveBiologicalBiological MarkersBrainBreast FeedingBuffersCaregiversCaringChildChild RearingChronicChronic stressDataDepositionDevelopmentExposure toGlareHairHair shaft structureHealthHormonesHourHouseholdHydrocortisoneHypothalamic structureInfantInterventionKnowledgeLeadLifeLife StressLinkLiteratureMeasuresMedicalMental HealthMethodologyMethodsNursery SchoolsOutcomePathway interactionsPhysiologicalPituitary GlandPovertyPredispositionPreschool ChildPreventive InterventionProcessPublic HealthRegulationResearchResearch PersonnelRiskSalivarySamplingShapesSleepSocioeconomic StatusStressSystemTestingWorkacute stressbasecohortdaily functioningdesignearly childhoodenvironmental stressorexpectationexperiencehypothalamic-pituitary-adrenal axisimprovedindexinginfancyinnovationlow socioeconomic statusphysical conditioningpreventpsychosocialpublic health relevancesocialstressor
项目摘要
DESCRIPTION: Children who experience chronic stress in early childhood are at risk for poor physical and mental health in adulthood. Early life stress shapes biological stress systems, with lifelong health consequences. Given the powerful long term implications of early life stress for public health, it is important to investigate how chronic early life stress exerts such far-reachin effects and which environmental stressors have the greatest impact on biological stress. Young children depend on sensitive caregivers to provide social buffering, protecting the developing brain from being exposed to too much of the stress hormone cortisol. However, poverty, household chaos, and parenting stress can disrupt this social buffering and may increase exposure to the stress hormone cortisol. To fully understand this process, a biological marker of chronic stress in infancy and early childhood is critically needed. Salivary cortisol, the most widely used marker of biological stress, measures acute rather than chronic stress, and salivary cortisol levels vary greatly from day to day. Cortisol is deposited in the hair shaft as it grows, o hair cortisol measures chronic stress over several months with a single sample. We and others have demonstrated the feasibility of measuring hair cortisol in young children. Yet much remains unknown about how this new method relates to established salivary cortisol methods. Salivary and hair measures may provide distinct information about the biological stress system, indexing daily regulation versus cumulative exposure. It is critical for researchers to make informed decisions about whether to use hair or salivary cortisol measures or both, as we work toward a comprehensive understanding of the processes through which early life stress influences biological stress systems. The current study will measure hair and salivary cortisol in 80 infants and 80 preschool children. Our first objective is to examine the extent to which hair cortisol and diurnal salivary cortisol measures are related in young children. Our second objective is to understand how established early life stressors relate to hair cortisol levels in young children. We will assess maternal sensitivity; maternal hair cortisol; maternal and paternal perceived stress; sleep; breastfeeding; childcare; fearfulness; household chaos; and socioeconomic status (SES) as predictors of this hair cortisol measure of chronic stress. This essential research will yield valuable data about how the innovative hair cortisol measure compares to ubiquitous salivary cortisol measures for two age cohorts, infancy and preschool, and how it relates to environmental stressors. Results will move the field forward in the quest to fully understand how early life stress shapes the development of biological stress systems. Ultimately, this knowledge will inform targeted prevention and intervention approaches to buffer young children from the biological consequences of early life stress, thus reducing long term public health burden.
描述:在儿童早期经历慢性压力的儿童在成年后有身心健康不良的风险。早期生活压力塑造了生物压力系统,对健康产生终身影响。考虑到早期生活压力对公共卫生的长期影响,研究慢性早期生活压力如何产生如此深远的影响以及哪些环境压力对生物压力影响最大是很重要的。幼儿依赖敏感的照顾者提供社会缓冲,保护发育中的大脑免受过多的应激激素皮质醇的影响。然而,贫困、家庭混乱和养育压力会破坏这种社会缓冲,并可能增加压力荷尔蒙皮质醇的暴露。为了充分理解这一过程,迫切需要一种婴儿和幼儿期慢性压力的生物标志物。唾液皮质醇是最广泛使用的生物压力标志物,它测量的是急性压力而不是慢性压力,唾液皮质醇水平每天变化很大。皮质醇在头发生长的过程中沉积在毛干中,o头发皮质醇可以用一个样本测量几个月的慢性压力。我们和其他人已经证明了测量幼儿头发皮质醇的可行性。然而,关于这种新方法如何与已建立的唾液皮质醇方法相关,仍有很多未知数。唾液和毛发测量可以提供关于生物应激系统的不同信息,索引每日调节与累积暴露。对于研究人员来说,是否使用头发或唾液皮质醇测量或两者兼而有之做出明智的决定至关重要,因为我们正在努力全面了解早期生活压力影响生物压力系统的过程。目前的研究将测量80名婴儿和80名学龄前儿童的头发和唾液皮质醇。我们的第一个目标是研究在多大程度上头发皮质醇和昼夜唾液皮质醇措施相关的幼儿。我们的第二个目标是了解如何建立早期生活的压力与头发皮质醇水平的幼儿。我们将评估母亲的敏感性;母亲的头发皮质醇;母亲和父亲的感知压力;睡眠;母乳喂养;儿童保育;恐惧;家庭混乱;和社会经济地位(SES)作为这种头发皮质醇测量慢性压力的预测因素。这项重要的研究将产生有价值的数据,说明创新的头发皮质醇测量方法与婴儿期和学龄前两个年龄组普遍存在的唾液皮质醇测量方法相比,以及它与环境压力源的关系。研究结果将推动该领域的研究,以充分了解早期生活压力如何塑造生物压力系统的发展。最终,这些知识将为有针对性的预防和干预措施提供信息,以缓冲幼儿早期生活压力的生物后果,从而减少长期的公共卫生负担。
项目成果
期刊论文数量(0)
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Amanda Tarullo其他文献
Amanda Tarullo的其他文献
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{{ truncateString('Amanda Tarullo', 18)}}的其他基金
Advancing Engagement and Efficacy of Interventions for Co-Morbid Sleep and BehaviorProblems in Young Children
提高幼儿共病睡眠和行为问题干预措施的参与度和有效性
- 批准号:
10417077 - 财政年份:2020
- 资助金额:
$ 8.89万 - 项目类别:
Advancing Engagement and Efficacy of Interventions for Co-Morbid Sleep and BehaviorProblems in Young Children
提高幼儿共病睡眠和行为问题干预措施的参与度和有效性
- 批准号:
10158521 - 财政年份:2020
- 资助金额:
$ 8.89万 - 项目类别:
Advancing Engagement and Efficacy of Interventions for Co-Morbid Sleep and BehaviorProblems in Young Children
提高幼儿共病睡眠和行为问题干预措施的参与度和有效性
- 批准号:
9885424 - 财政年份:2020
- 资助金额:
$ 8.89万 - 项目类别:
Advancing Engagement and Efficacy of Interventions for Co-Morbid Sleep and BehaviorProblems in Young Children
提高幼儿共病睡眠和行为问题干预措施的参与度和有效性
- 批准号:
10612901 - 财政年份:2020
- 资助金额:
$ 8.89万 - 项目类别:
Hair Cortisol as a Biomarker of Chronic Early Life Stress
头发皮质醇作为慢性早期生活压力的生物标志物
- 批准号:
9043154 - 财政年份:2015
- 资助金额:
$ 8.89万 - 项目类别:
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