A neuroprosthesis for seated posture and balance
用于坐姿和平衡的神经假体
基本信息
- 批准号:8486090
- 负责人:
- 金额:--
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2013
- 资助国家:美国
- 起止时间:2013-08-01 至 2017-07-31
- 项目状态:已结题
- 来源:
- 关键词:AbdomenAccelerationActivities of Daily LivingClinicalClinical TrialsCommunitiesConsciousDataDisabled PersonsEnvironmentEquilibriumFall preventionFlexorFutureGenerationsHealthHealthcare SystemsHip region structureHome environmentImplantInterventionLateralLeisure ActivitiesLifeLife StyleManual wheelchairMeasuresMechanicsMuscleParalysedPatternPerceptionPerformancePersonal SatisfactionPhasePopulationPosturePreparationProceduresRecruitment ActivitySafetySelf StimulationSignal TransductionSpecific qualifier valueSpeedSpinal cord injuryStimulusStrokeSurfaceSystemTelemetryVeteransWheelchair propulsionWheelchairsWireless TechnologyWorkbasefallsfear of fallingimplantable deviceimprovedneuroprosthesisnew technologyprogramspublic health relevancesensorskeletalsocialtelemetering
项目摘要
DESCRIPTION (provided by applicant):
Spinal cord injury (SCI) can result in paralysis of the core trunk and hip musculature which compromises the ability to stabilize the torso while reaching, resist disturbances to sitting balance, and efficiently propel a manual wheelchair. Constant stimulation of the trunk and hip extensor muscles can positively alter seated posture, extend bimanual reach, restore erect sitting, and improve wheelchair propulsion mechanics at slow speeds and on level surfaces. However, continuously activating the trunk and hip extensors is unresponsive to the dynamically changing demands of many activities of daily living and does not contribute to attaining forward leaning postures or resisting rearward directed disturbances. First-generation systems also require users to intentionally select a discrete pattern of stimulation for each desired function from a fixed menu of pre-programmed options. The purpose of this study is to expand the functional impact of neuroprostheses for seated posture and balance by a) incorporating the abdominal and hip flexor muscles to enhance trunk stiffness through co-contraction with the extensors, b) synchronizing stimulation with the stroke cycle to improve wheelchair propulsion efficiency, c) providing automatic righting actions to maintain upright posture, prevent falls and
extend forward reach, and d) integrating these approaches into an advanced sensor-driven trunk control system with currently available implantable devices in preparation for transitioning
to new technologies suitable for clinical dissemination. The implanted EMG telemetry and expanded channel count of our second-generation implanted stimulator-telemeter (IST) will be utilized to implement advanced neuroprostheses for seated function. Two channels of EMG data will detect transitions between contact and return phases of propulsion and switch between appropriate stimulus patterns without conscious effort by the user. Performance of continuous co-activation of the hip/trunk flexor and extensor muscles will be compared to phasic activation of the muscles in terms of propulsion mechanics, efficiency, and subjective perception of effort on level and inclined surfaces and at various speeds. Control systems based on an inexpensive commercially available wireless 3D accelerometer will be implemented to detect impending forward or lateral falls and appropriately modulate stimulation to restore upright posture and sitting balance. Efficacy will be evaluated in terms of forward reach, rejection of disturbances, independence and safety of transfers, and both patterns of usage and fear of falling in the home and community environments. Complementary information from upper body EMG and trunk accelerations will be combined into a single control system to automatically regulate stimulation for self-righting and propulsion over various surfaces and speeds without intentional intervention by the user. Ability to discriminate between dynamic activities such as starts, stops, bumpy or inclined terrain and obstacle collisions will be determined. Usage patterns and measures of independence in the home and community will document the effects of the comprehensive control system. This translational project will establish the feasibility of a new intervention fr maximizing seated stability, facilitating personal mobility and enhancing the safety and functional independence of veterans with SCI, and in so doing define the most effective implementation for future clinical trials and widespread distribution throughout the VA healthcare system.
PUBLIC HEALTH RELEVANCE:
Spinal cord injury (SCI) significantly restricts access to life opportunities and compromises the ability to work, engage in social or leisure activities, and assume an independent and productive lifestyle. Activating the paralyzed hip and trunk muscles can promote healthy skeletal alignment, restore and maintain erect sitting postures, extend bimanual reach and the ability manipulate objects, prevent falls, improve the efficiency of manual wheelchair propulsion and facilitate transfers and other activities of daily living. This project is important because it specifies a comprehensive control system for restoring sitting posture and balance that can improve seated function by stiffening the trunk in task-dependent manners without conscious effort by the user. It is directly applicable to the health and well-being of disabled veterans who
are over-represented in the SCI population.
描述(由申请人提供):
脊髓损伤(SCI)可导致躯干和臀部肌肉组织的瘫痪,这损害了在达到时稳定躯干的能力,抵抗坐姿平衡的干扰,并有效地推动手动轮椅。持续刺激躯干和臀部伸肌可以积极地改变坐姿,延长双手伸展,恢复直立坐姿,并改善轮椅在低速和水平表面上的推进力学。 然而,连续激活躯干和臀部伸肌对许多日常生活活动的动态变化的需求没有反应,并且无助于获得前倾姿势或抵抗向后定向的干扰。第一代系统还要求用户从预编程选项的固定菜单中为每个所需功能有意选择离散的刺激模式。本研究的目的是通过以下方式扩大神经假体对坐姿和平衡的功能影响:a)通过与伸肌共同收缩,结合腹部和髋屈肌以增强躯干刚度,B)使刺激与划水周期同步以提高轮椅推进效率,c)提供自动扶正动作以保持直立姿势,防止福尔斯,
扩展前伸范围,以及d)将这些方法与当前可用的可植入设备集成到先进的传感器驱动的躯干控制系统中,以准备过渡
适合临床传播的新技术。 我们的第二代植入式刺激遥测仪(IST)的植入式EMG遥测和扩展通道计数将用于实现先进的神经假体的坐姿功能。EMG数据的两个通道将检测推进的接触和返回阶段之间的转换,并在适当的刺激模式之间切换,而无需用户有意识的努力。髋关节/躯干屈肌和伸肌的连续共同激活的性能将与肌肉的阶段性激活在推进力学、效率和在水平和倾斜表面上以及在各种速度下的主观感觉方面进行比较。将实施基于廉价的市售无线3D加速度计的控制系统,以检测即将发生的向前或侧向福尔斯跌倒,并适当地调节刺激以恢复直立姿势和坐姿平衡。将从前伸、拒绝干扰、转移的独立性和安全性以及在家庭和社区环境中的使用模式和对跌倒的恐惧等方面评估功效。 来自上身EMG和躯干加速度的补充信息将被组合到单个控制系统中,以自动调节刺激,用于在各种表面和速度上的自翻正和推进,而无需用户的故意干预。区分动态活动的能力,如启动,停止,颠簸或倾斜的地形和障碍物碰撞将被确定。使用模式和措施的独立性在家庭和社区将文件的综合控制系统的效果。 该转化项目将确定一种新干预措施的可行性,以最大限度地提高坐姿稳定性,促进个人移动性,提高SCI退伍军人的安全性和功能独立性,并在此过程中为未来的临床试验和整个VA医疗保健系统的广泛分布确定最有效的实施方案。
公共卫生关系:
脊髓损伤(SCI)严重限制了获得生活机会的机会,并损害了工作,参与社交或休闲活动以及采取独立和富有成效的生活方式的能力。激活瘫痪的臀部和躯干肌肉可以促进健康的骨骼排列,恢复和保持直立的坐姿,延长双手伸展和操纵物体的能力,防止福尔斯,提高手动轮椅推进的效率,并促进转移和其他日常生活活动。该项目非常重要,因为它指定了一个用于恢复坐姿和平衡的综合控制系统,该系统可以通过以任务依赖的方式加强躯干而无需用户有意识地努力来改善坐姿功能。它直接适用于残疾退伍军人的健康和福祉,
在SCI患者中的比例过高。
项目成果
期刊论文数量(0)
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科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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{{ truncateString('RONALD J TRIOLO', 18)}}的其他基金
Functional and Neuroprotective Effects of Restoring Lower Limb Sensation after Diabetic Peripheral Neuropathy
糖尿病周围神经病变后恢复下肢感觉的功能和神经保护作用
- 批准号:
10599863 - 财政年份:2021
- 资助金额:
-- - 项目类别:
Functional and Neuroprotective Effects of Restoring Lower Limb Sensation after Diabetic Peripheral Neuropathy
糖尿病周围神经病变后恢复下肢感觉的功能和神经保护作用
- 批准号:
10390351 - 财政年份:2021
- 资助金额:
-- - 项目类别:
Functional and Neuroprotective Effects of Restoring Lower Limb Sensation after Diabetic Peripheral Neuropathy
糖尿病周围神经病变后恢复下肢感觉的功能和神经保护作用
- 批准号:
10184521 - 财政年份:2021
- 资助金额:
-- - 项目类别:
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- 资助金额:
-- - 项目类别:
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刺激结合外部动力电动矫形器治疗中风
- 批准号:
10543078 - 财政年份:2020
- 资助金额:
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Hybrid neuroprosthesis with power assist for walking in SCI
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9768248 - 财政年份:2016
- 资助金额:
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- 批准号:
9525331 - 财政年份:2013
- 资助金额:
-- - 项目类别:
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