Senior Research Career Scientist

高级研究职业科学家

• 批准号: 10672971
• 负责人: RONALD J TRIOLO
• 金额: --
• 依托单位: LOUIS STOKES CLEVELAND VA MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-10-01 至 2028-09-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10672971
• 关键词: Achievement; Acute; Address; Adopted; Affect; American; Amputation; Amputees; Animals; Ankle; Architecture; Archives; Area; Award; Biomechanics; Biomedical Engineering; Book Chapters; Central Nervous System; Chronic; Chronic Disease; Clinical; Collaborations; Communities; Community Participation; Contracts; Dedications; Development; Devices; Diabetes Mellitus; Disabled Persons; Education; Electrodes; Employee; Environment; Equilibrium; Esthesia; Etiology; Exercise; Exhibits; Fall prevention; Fatigue; Femur; Floor; Funding; Gait; Gait abnormality; Health; Healthcare; Heart; Hospital Costs; Human; Immobilization; Impairment; Implant; Individual; Injury; Intervention; Intuition; Joints; Journals; Knee; Laboratory Study; Legal patent; Leisure Activities; Life Style; Limb Prosthesis; Limb structure; Location; Lower Extremity; Lung; Malignant Neoplasms; Manual wheelchair; Manuals; Manufacturer; Mechanics; Mechanoreceptors; Mediation; Medical; Medical Device; Medical Students; Medical center; Medicine; Mentors; Methods; Modality; Motion; Motor; Movement; Multi-Institutional Clinical Trial; Multiple Sclerosis; Muscle; Muscle Contraction; Musculoskeletal Equilibrium; Names; Nerve; Neuromechanics; Neuromuscular Diseases; Neurons; Operative Surgical Procedures; Output; Paper; Paralysed; Participant; Peer Review; Pelvis; Perception; Performance; Peripheral; Peripheral Nerves; Personal Satisfaction; Phase; Physical Medicine; Physical Rehabilitation; Population; Postdoctoral Fellow; Posture; Preclinical Testing; Principal Investigator; Process; Productivity; Psychophysics; Publications; Ramp; Reaction; Recurrence; Rehabilitation therapy; Reporting; Research; Research Personnel; Risk; Safety; Scientist; Self-Help Devices; Seminal; Sensory; Series; Services; Site; Skin; Social isolation; Spinal Cord; Spinal cord injury; Stroke; System; Technology; Textbooks; Tissues; Translations; Trauma; United States Department of Veterans Affairs; United States National Institutes of Health; Universities; Vertebral column; Veterans; Veterans Health Administration; Visual; Walking; Wheelchair propulsion; Wheelchairs; Work; body system; bone; career; clinical application; clinical translation; computerized tools; cost; design; diabetic; disability; erection; exercise intervention; exoskeleton; experience; fall injury; falls; feasibility trial; first-in-human; foot; functional independence; graduate student; improved; innovation; limb loss; neural; neural implant; neural prosthesis; neural stimulation; neuroprosthesis; novel; prevent; programs; rehabilitation research; research and development; residual limb; sciatic nerve; sedentary lifestyle; senior faculty; social; spine bone structure; surgery outcome; technology platform; technology/technique; translational framework; unhealthy lifestyle; walking speed

Dr. Ronald J. Triolo is Senior Research Career Scientist with the Rehabilitation R&D Service, and a Tenured Full Professor of Biomedical Engineering at Case Western Reserve University. He is Executive Director of the VA RR&D Center for Advanced Platform Technology which develops novel medical devices and assistive restorative technologies for individuals with sensorimotor impairments or limb loss. Dr. Triolo has authored over 150 peer-reviewed publications and textbook chapters, and has mentored more than 40 graduate and medical students or post-doctoral trainees. He currently leads independent research programs funded the VA, NIH, DoD and other agencies as Principal or Co-Principal Investigator. Dr. Triolo was inducted into the American Institute for Medical and Biological Engineering, received the Paul B. Magnuson Award for outstanding achievement in Rehabilitation Research and Development from the VA, and was named the Outstanding Veterans Health Administration Employee (Honorable Mention) of 2020 by the Disabled American Veterans (DAV). Dr. Triolo has devised, patented and evaluated assistive devices to facilitate the sit-to-stand transition and negotiate stairs, ramps or other architectural barriers, and is in the process of preparing novel interventions for exercising after spinal cord injury (SCI) for dissemination within the VHA. His research program encompasses five main areas: 1. Implanted Neuroprostheses for Standing and Walking: Dr. Triolo leads an interdisciplinary team dedicated to developing, deploying, and evaluating the clinical outcomes of surgically implanted motor system neuroprostheses for lower extremity function after SCI. He quantifies their acute and chronic performances, and explores novel methods of integrating stimulated and volitional muscle activity. His team creates new computational tools to analyze the biomechanics of bipedal stance and stepping, and applies them to optimize control systems for maintaining erect balance or facilitating efficient walking. 2. Seated Balance and Wheelchair Propulsion: This research explores methods to control the paralyzed pelvis and spine to restore vertebral alignment, extend bimanual reach, provide active sitting balance, and enhance mechanical efficiency of manual wheelchair propulsion. Dr. Triolo documents the effects of modulating stiffness of the trunk on regulating upright posture to prevent falls from the wheelchair and expand control over objects in the environment. 3. Selective Peripheral Nerve Interfaces: Dr. Triolo has designed and verified the safety and performance of new, highly selective multicontact peripheral nerve electrodes capable of isolating functionally distinct fascicular groups within a common nerve trunk. Selectivly activating of independent groups of neurons can elicit multiple joint motions, or discrete sensations perceived as arising from the missing limb, from a common surgical site on the proximal nerve, and alternating between synergistic motor unit pools can prolong force output and delay onset of fatigue. 4. Natural Sensation for Lower Limb Amputees: This program applies selective multicontact nerve electrodes to activate the sensory components of the sciatic nerve above the knee in the residual limbs of amputees to induce sensations referred to the missing limb. Elicited sensory information is processed by the CNS in a manner similar to input from intact mechanoreceptors, and can improve standing and ambulatory ability after traumatic or diabetic limb loss, and is being integrating with motorized lower limb prostheses. 5. Neuromechanical Gait Assist Systems: Dr. Triolo develops novel exoskeletal systems to facilitate bipedal mobility for individuals with SCI or other neuromuscular disorders. His innovative “muscle first” approach integrates mechanical components with volitional or electrically activated muscle contractions to maximize physical benefit and achieve the walking speeds required for community ambulation.

罗纳德·J·特里奥洛博士是康复研究与发展服务的高级研究职业科学家，也是一名终身教授 凯斯西储大学生物医学工程正教授。他是执行董事 退伍军人事务部高级平台技术研发中心，该中心开发新型医疗设备和 为有感觉运动障碍或肢体丧失的个人提供辅助恢复技术。特里奥罗医生已经 撰写了150多本同行评议的出版物和教科书章节，并指导了40多本 研究生、医学生或博士后实习生。他目前领导着独立的研究项目 资助退伍军人事务部、国家卫生研究院、国防部和其他机构作为主要或联合主要调查员。特里奥罗博士是入职的 进入美国医学和生物工程研究所，获得保罗·B·马格努森奖 荣获退伍军人管理局颁发的康复研究与发展杰出成就奖 被评为2020年度退伍军人健康管理局杰出员工(荣誉奖) 残疾美国退伍军人(DAV)。特里奥罗博士设计、申请了专利，并对辅助设备进行了评估 促进从坐到站的过渡，并通过楼梯、坡道或其他建筑障碍，并在 为脊髓损伤(SCI)后的运动准备新的干预措施的过程 VHA。他的研究计划包括五个主要领域： 1.植入用于站立和行走的神经假体：特里奥洛博士领导一个跨学科团队 致力于开发、部署和评估外科植入的运动系统的临床结果 神经假体对脊髓损伤后肢体功能的影响。他量化了他们的急性和慢性表现， 并探索整合受刺激和意志性肌肉活动的新方法。他的团队创造了新的 分析两足动物站姿和步态生物力学的计算工具，并将其应用于优化 用于保持直立平衡或促进高效行走的控制系统。 2.坐姿平衡与轮椅推进：本研究探索控制瘫痪患者的方法 骨盆和脊柱，以恢复脊柱对齐，延长双手伸展，提供积极的坐姿平衡，以及 提高手动轮椅推进的机械效率。特里奥罗博士记录了 调节后备箱的刚度调整直立姿势防止从轮椅上坠落和伸展 控制环境中的对象。 3.选择性周围神经接口：Triolo博士设计并验证了安全性和性能 一种新的、高度选择性的多接触周围神经电极，能够隔离功能上不同的 共同神经干内的束状群。选择性地激活独立的神经元群可以 引起多个关节运动，或感觉到从缺失的肢体产生的离散感觉 手术部位在近端神经上，协同运动单位池之间的交替可以延长力量 输出和延迟疲劳的开始。 4.下肢截肢者的自然感觉：本计划采用选择性多点接触神经 激活膝关节以上残肢坐骨神经感觉成分的电极 截肢者要诱发涉及缺失肢体的感觉。被引出的感觉信息由 中枢神经系统以类似于完整机械感受器输入的方式，可以改善站立和行走能力 在创伤或糖尿病肢体丧失后的能力，并正在与电动假肢集成。 5.神经机械步态辅助系统：Triolo博士开发了新的外骨骼系统，以促进 脊髓损伤或其他神经肌肉疾病患者的两足活动能力。他创新的“肌肉优先” 该方法将机械部件与意志或电激活的肌肉收缩相结合，以 最大限度地提高身体健康，达到社区步行所需的步行速度。