Neuromodulation of Cognition in Older Adults
老年人认知的神经调节
基本信息
- 批准号:9104290
- 负责人:
- 金额:$ 11.98万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2016
- 资助国家:美国
- 起止时间:2016-09-30 至 2021-05-31
- 项目状态:已结题
- 来源:
- 关键词:AddressAdultAgeAge-associated memory impairmentAgingAreaAttentionAwardBasic ScienceBehaviorBehavioralBiological MarkersBrainBrain regionCerebrumCholineClinicalCognitionCognitiveCognitive agingCoupledCouplingDataDevelopmentDiscriminationEducationEducational InterventionElderlyElectrophysiology (science)EnrollmentFoundationsFunctional Magnetic Resonance ImagingFundingGrowthImageImage AnalysisImpaired cognitionIndividualInferiorInterventionKnowledgeLearningMagnetic Resonance ImagingMagnetic Resonance SpectroscopyMeasuresMedialMetabolicMetabolismMethodsMotorN-acetylaspartateNatureNeurocognitiveNeuronal PlasticityParietal LobeParticipantPerformancePhysiologicalPlacebosPopulationProtonsPublic HealthRandomizedReadinessRecruitment ActivityResearchRestScienceSecondary toSharkShort-Term MemoryStructureSystemTestingTimeTrainingTraining and EducationTranslatingTranslational Researchassociation cortexbasecareercareer developmentcingulate cortexcognitive abilitycognitive functioncognitive neurosciencecognitive taskcognitive trainingcohortcombatdesigneffective interventionexecutive functionexperiencefollow-upfrontal lobefunctional improvementfunctional statusgamma-Aminobutyric Acidimaging modalityimprovedinsightmemory encodingmyoinositolneuroimagingneuromechanismneuroregulationnovelpreventpublic health relevancerelating to nervous systemremediationresponseskillssuccess
项目摘要
DESCRIPTION (provided by applicant): This project will answer important questions regarding remediation of cognitive decline in older adults and address two critical areas of training: advanced imaging (magnetic resonance spectroscopy, functional connectivity) and cognitive/clinical aging interventions (cognitive training). The PI is a cognitive neuroscientist wth a strong background in transcranial direct current stimulation (tDCS), cognition, and electrophysiology, as well as a basic understanding of magnetic resonance imaging. The K01 will provide protected time and training to focus his research career firmly in cognitive aging, specifically focusing on the development of novel non- invasive treatments for age-related cognitive decline. This training will afford the knowledge required to translate his basic science expertise into clinical translational applications in aging populations. The current study will investigate a method for enhancing cognitive training effects in healthy older adults and improving functional transfer of skills by employing a combined intervention approach targeting facilitation of neural plasticity and optimal learning state. Adults over the age of 65 represent te fastest growing portion of the US population. As such, age-related cognitive decline represents a major concern for public health. Recent research suggests that cognitive training in older adults can have lasting effects on performance, lasting up to 10 years. However, these effects are typically limited to the tasks trained, with little transfer to other cognitive abilities or evryday skills. This study will examine the impact of pairing cognitive training with tDCS. Individual effects of tDCS and cognitive training on cognitive, functional, and neuroimaging measures will be assessed. tDCS is a non-invasive brain stimulation method that directly stimulates brain regions involved in active cognitive function and enhances neural plasticity when paired with a variety of cognitive tasks. We will compare changes in cognitive and brain function resulting from cognitive training and cognitive training combined with tDCS using a comprehensive neurocognitive, clinical, and multimodal neuroimaging assessment of brain structure, function, and metabolic state. Functional connectivity from functional magnetic resonance imaging (fMRI) will be used to assess the coherence of brain response during working memory and focused attention; the active cognitive abilities trained by cognitive training. Proton magnetic resonance spectroscopy (MRS) will assess cerebral metabolites, including GABA concentrations sensitive to neural plasticity in task-associated brain ROIs. We hypothesize that: 1) tDCS will enhance neurocognitive function, brain function, and functional improvements from cognitive training; 2) Effects of tDCS on cognitive training will be maintained up to 3 months following training; and 3) Neuroimaging biomarkers of cerebral metabolism, neural plasticity (GABA concentrations) and coherence of functional brain response (fMRI) in default network and functionally relevant brain regions will predict individual response to cognitive training and tDCS.
DESCRIPTION (provided by applicant): This project will answer important questions regarding remediation of cognitive decline in older adults and address two critical areas of training: advanced imaging (magnetic resonance spectroscopy, functional connectivity) and cognitive/clinical aging interventions (cognitive training). The PI is a cognitive neuroscientist wth a strong background in transcranial direct current stimulation (tDCS), cognition, and electrophysiology, as well as a basic understanding of magnetic resonance imaging. The K01 will provide protected time and training to focus his research career firmly in cognitive aging, specifically focusing on the development of novel non- invasive treatments for age-related cognitive decline. This training will afford the knowledge required to translate his basic science expertise into clinical translational applications in aging populations. The current study will investigate a method for enhancing cognitive training effects in healthy older adults and improving functional transfer of skills by employing a combined intervention approach targeting facilitation of neural plasticity and optimal learning state. Adults over the age of 65 represent te fastest growing portion of the US population. As such, age-related cognitive decline represents a major concern for public health. Recent research suggests that cognitive training in older adults can have lasting effects on performance, lasting up to 10 years. However, these effects are typically limited to the tasks trained, with little transfer to other cognitive abilities or evryday skills. This study will examine the impact of pairing cognitive training with tDCS. Individual effects of tDCS and cognitive training on cognitive, functional, and neuroimaging measures will be assessed. tDCS is a non-invasive brain stimulation method that directly stimulates brain regions involved in active cognitive function and enhances neural plasticity when paired with a variety of cognitive tasks. We will compare changes in cognitive and brain function resulting from cognitive training and cognitive training combined with tDCS using a comprehensive neurocognitive, clinical, and multimodal neuroimaging assessment of brain structure, function, and metabolic state. Functional connectivity from functional magnetic resonance imaging (fMRI) will be used to assess the coherence of brain response during working memory and focused attention; the active cognitive abilities trained by cognitive training. Proton magnetic resonance spectroscopy (MRS) will assess cerebral metabolites, including GABA concentrations sensitive to neural plasticity in task-associated brain ROIs. We hypothesize that: 1) tDCS will enhance neurocognitive function, brain function, and functional improvements from cognitive training; 2) Effects of tDCS on cognitive training will be maintained up to 3 months following training; and 3) Neuroimaging biomarkers of cerebral metabolism, neural plasticity (GABA concentrations) and coherence of functional brain response (fMRI) in default network and functionally relevant brain regions will predict individual response to cognitive training and tDCS.
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Adam J. Woods其他文献
Bilateral frontal tDCS reduces DLPFC activation during working memory performance in older adults
- DOI:
10.1016/j.brs.2017.04.079 - 发表时间:
2017-07-01 - 期刊:
- 影响因子:
- 作者:
Nicole R. Nissim;Andrew O’Shea;Lindsey Richards;Rachel Telles;Eric Porges;Ronald Cohen;Adam J. Woods - 通讯作者:
Adam J. Woods
Exploring structure-function relationships using parallel fMRI and tDCS
- DOI:
10.1016/j.brs.2014.01.033 - 发表时间:
2014-03-01 - 期刊:
- 影响因子:
- 作者:
Adam J. Woods;Roy Hamilton;Alexander Kranjec;Preet Minhaus;Marom Bikson;Jonathan Yu;Anjan Chatterjee - 通讯作者:
Anjan Chatterjee
Transcranial Direct Current Stimulation and Mobility Functioning in Older Adults with Knee Osteoarthritis Pain: A Double-Blind, Randomized, Sham-Controlled Pilot Clinical Study
- DOI:
10.1016/j.brs.2017.04.007 - 发表时间:
2017-07-01 - 期刊:
- 影响因子:
- 作者:
Hyochol Ahn;Adam J. Woods;Eunyoung Choi;Nikhil Padhye;Roger Fillingim - 通讯作者:
Roger Fillingim
Abstract #41: Effects of Bilateral-Frontal tDCS on the Working Memory Network: an fMRI-tDCS Study in Older Adults
- DOI:
10.1016/j.brs.2018.12.048 - 发表时间:
2019-03-01 - 期刊:
- 影响因子:
- 作者:
Nicole R. Nissim;Andrew O'Shea;Lindsey A. Richards;Rachel Telles;Eric Porges;Ronald Cohen;Adam J. Woods - 通讯作者:
Adam J. Woods
Abstract #125: Failure Of Conventional Signal Processing Techniques To Remove “Physiological” Artifacts From EEG During tDCS
- DOI:
10.1016/j.brs.2018.12.132 - 发表时间:
2019-03-01 - 期刊:
- 影响因子:
- 作者:
Nigel Gebodh;Zeinab Esmaeilpour;Devin Adair;Kenneth Chelette;Jacek Dmochowski;Lucas Parra;Adam J. Woods;Emily S. Kappenman;Marom Bikson - 通讯作者:
Marom Bikson
Adam J. Woods的其他文献
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