Neuromodulation of Cognition in Older Adults

老年人认知的神经调节

• 批准号: 9353281
• 负责人: Adam J. Woods
• 金额: $ 12.27万
• 依托单位: UNIVERSITY OF FLORIDA
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-09-30 至 2021-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9353281
• 关键词: Address; Adult; Age; Age-associated memory impairment; Aging; Area; Attention; Award; Basic Science; Behavior; Behavioral; Brain; Brain region; Cerebrum; Choline; Clinical; Cognition; Cognitive; Cognitive aging; Cognitive remediation; Coupled; Coupling; Data; Development; Discrimination; Duct (organ) structure; Education; Educational Intervention; Elderly; Electrophysiology (science); Enrollment; Foundations; Functional Magnetic Resonance Imaging; Funding; Growth; Image; Image Analysis; Impaired cognition; Individual; Inferior; Intervention; Knowledge; Learning; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Measures; Medial; Metabolic; Metabolism; Methods; Motor; N-acetylaspartate; Nature; Neurocognitive; Neuronal Plasticity; Parietal Lobe; Participant; Performance; Physiological; Placebos; Population; Protons; Public Health; Randomized; Readiness; Recruitment Activity; Research; Rest; Science; Secondary to; Shark; Short-Term Memory; Structure; System; Testing; Time; Training; Training and Education; Transferable Skills; Translating; Translational Research; association cortex; base; career; career development; cingulate cortex; cognitive ability; cognitive enhancement; cognitive function; cognitive neuroscience; cognitive task; cognitive training; cohort; combat; design; effective intervention; executive function; experience; follow-up; frontal lobe; functional improvement; functional status; gamma-Aminobutyric Acid; imaging modality; improved; insight; memory encoding; multimodality; myoinositol; neuroimaging; neuroimaging marker; neuromechanism; neuroregulation; novel; power analysis; prevent; public health relevance; relating to nervous system; response; skills; success

 DESCRIPTION (provided by applicant): This project will answer important questions regarding remediation of cognitive decline in older adults and address two critical areas of training: advanced imaging (magnetic resonance spectroscopy, functional connectivity) and cognitive/clinical aging interventions (cognitive training). The PI is a cognitive neuroscientist wth a strong background in transcranial direct current stimulation (tDCS), cognition, and electrophysiology, as well as a basic understanding of magnetic resonance imaging. The K01 will provide protected time and training to focus his research career firmly in cognitive aging, specifically focusing on the development of novel non- invasive treatments for age-related cognitive decline. This training will afford the knowledge required to translate his basic science expertise into clinical translational applications in aging populations. The current study will investigate a method for enhancing cognitive training effects in healthy older adults and improving functional transfer of skills by employing a combined intervention approach targeting facilitation of neural plasticity and optimal learning state. Adults over the age of 65 represent te fastest growing portion of the US population. As such, age-related cognitive decline represents a major concern for public health. Recent research suggests that cognitive training in older adults can have lasting effects on performance, lasting up to 10 years. However, these effects are typically limited to the tasks trained, with little transfer to other cognitive abilities or evryday skills. This study will examine the impact of pairing cognitive training with tDCS. Individual effects of tDCS and cognitive training on cognitive, functional, and neuroimaging measures will be assessed. tDCS is a non-invasive brain stimulation method that directly stimulates brain regions involved in active cognitive function and enhances neural plasticity when paired with a variety of cognitive tasks. We will compare changes in cognitive and brain function resulting from cognitive training and cognitive training combined with tDCS using a comprehensive neurocognitive, clinical, and multimodal neuroimaging assessment of brain structure, function, and metabolic state. Functional connectivity from functional magnetic resonance imaging (fMRI) will be used to assess the coherence of brain response during working memory and focused attention; the active cognitive abilities trained by cognitive training. Proton magnetic resonance spectroscopy (MRS) will assess cerebral metabolites, including GABA concentrations sensitive to neural plasticity in task-associated brain ROIs. We hypothesize that: 1) tDCS will enhance neurocognitive function, brain function, and functional improvements from cognitive training; 2) Effects of tDCS on cognitive training will be maintained up to 3 months following training; and 3) Neuroimaging biomarkers of cerebral metabolism, neural plasticity (GABA concentrations) and coherence of functional brain response (fMRI) in default network and functionally relevant brain regions will predict individual response to cognitive training and tDCS.

 描述（由申请人提供）：该项目将回答有关老年人认知衰退补救的重要问题，并解决两个关键的培训领域：高级成像（磁共振波谱、功能连接）和认知/临床衰老干预（认知训练）。 PI 是一位认知神经科学家，在经颅直流电刺激 (tDCS)、认知和电生理学方面拥有深厚的背景，并对磁共振成像有基本的了解。 K01 将提供受保护的时间和培训，使他的研究生涯坚定地集中在认知衰老方面，特别是专注于开发针对与年龄相关的认知衰退的新型非侵入性治疗方法。该培训将提供将他的基础科学专业知识转化为老龄化人口的临床转化应用所需的知识。 目前的研究将探讨一种通过采用旨在促进神经可塑性和最佳学习状态的组合干预方法来增强健康老年人认知训练效果并改善技能功能转移的方法。 65 岁以上的成年人是美国人口中增长最快的部分。因此，与年龄相关的认知能力下降是公共卫生的一个主要问题。最近的研究表明，老年人的认知训练可以对表现产生持久的影响，可持续长达 10 年。然而，这些效果通常仅限于训练的任务，很少转移到其他认知能力或日常技能。本研究将探讨认知训练与经颅直流电刺激 (tDCS) 配对的影响。将评估 tDCS 和认知训练对认知、功能和神经影像测量的个体影响。 tDCS是一种非侵入性脑刺激方法，可直接刺激参与主动认知功能的大脑区域，并在与各种认知任务配合时增强神经可塑性。我们将使用对大脑结构、功能和代谢状态的综合神经认知、临床和多模式神经影像评估，比较认知训练和认知训练与 tDCS 相结合所引起的认知和大脑功能的变化。功能磁共振成像（fMRI）的功能连接将用于评估工作记忆和集中注意力期间大脑反应的一致性；通过认知训练训练出的主动认知能力。质子磁共振波谱 (MRS) 将评估大脑代谢物，包括对任务相关大脑 ROI 中的神经可塑性敏感的 GABA 浓度。我们假设：1）tDCS 将增强神经认知功能、大脑功能以及认知训练带来的功能改善； 2) tDCS对认知训练的效果将维持至训练后3个月； 3) 默认网络和功能相关大脑区域中大脑代谢、神经可塑性（GABA 浓度）和功能性大脑反应一致性（fMRI）的神经影像生物标志物将预测个体对认知训练和 tDCS 的反应。