How Can Precision Medicine be Applied to Temporomandibular Disorders and its Comorbidities?

精准医学如何应用于颞下颌关节疾病及其合并症？

• 批准号: 9193954
• 负责人: Allen W Cowley
• 金额: $ 3.1万
• 依托单位: TMJ ASSOCIATION
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-09-01 至 2017-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9193954
• 关键词: Address; Advocate; Affect; Age; American; Basic Science; Behavioral; Biology; Biomedical Research; Body part; Caring; Clinical; Clinical Research; Communities; Comorbidity; Complex; DNA Sequence; Data; Data Set; Diagnosis; Diagnostic; Disease; Epigenetic Process; Etiology; Funding; Genes; Genetic screening method; Goals; Government; Healthcare; Image; Individual; Lead; Maryland; Measurement; Mediating; Methods; Modality; Molecular; Neurologic; Onset of illness; Organ; Outcomes Research; Pain; Pathology; Patient Participation; Patient Representative; Patient-Focused Outcomes; Patients; Physiological; Precision Medicine Initiative; Prevention; Provider; Recommendation; Research; Research Institute; Research Personnel; Schedule; Science; Scientist; Societies; Subgroup; Technology; Temporomandibular Joint; Temporomandibular Joint Disorders; Testing; United States National Institutes of Health; Variant; Vision; Woman; child bearing; chronic pain; chronic widespread pain; effective therapy; experience; falls; improved; individualized medicine; meetings; new technology; next generation; precision medicine; psychologic; sex; symposium

PROJECT SUMMARY The Eighth Scientific Meeting of The TMJ Association, How Can Precision Medicine be applied to Temporomandibular Disorders and its Comorbidities?, is scheduled to be held on September 11-13, 2016 at the Federation of American Societies for Experimental Biology Conference Center in Bethesda, Maryland. The need for this meeting is driven by several critical issues: First, there are an estimated 36 million people affected by temporomandibular disorders (TMD) in the US, the majority being women in their childbearing years with consequential physical, psychological and financial burdens. Second, there continues to be a dearth of scientific understanding of the etiology of these conditions, their diagnosis, comorbidities and treatment. Third, TMD represents a chronic pain condition, which is one among a cluster of prevalent pain conditions that frequently co-occur and predominantly affect women. The 2016 meeting is focused on how methods of Precision Medicine can inform the treatment of TMD and the comorbid pain conditions so many patients experience. Current diagnostics and treatments do not reflect the current state of the science and fall short in meeting the needs of symptomatic patients. The application of Precision Medicine technology to TMD and its comorbidities will enable providers to more accurately classify TMD patients into subgroups according to specific diagnostic criteria and lead to tailored, more successful treatments to relieve their pain and suffering. Presentations and discussions will focus on the challenges of obtaining precise molecular and phenotypic measurements from thousands of patients, repeatedly and efficiently. Challenges addressing methods to analyze and integrate large data sets from multiple modalities such as clinical measurements, imaging data, DNA sequence variants, and epigenetic profiles will be addressed. The meeting will engage key scientific leaders, NIH representatives and patient advocates and will develop recommendations to advance research in this field. The Specific Aims of the conference are to: 1. Convene scientists to explore how “precision medicine” can be applied to advance the diagnostics and treatments of the unique pathologies of subsets of TMD patients and comorbid pain conditions. 2. To assess what kinds of studies could be mounted in precision medicine and how aggregated results of “N- of-1 trials” can provide information on how to improve treatment of patients with these pain conditions. 3. Determine which physiological and clinical tests (genetic, neurological, micobiomic, etc.) can best characterize subsets of TMD patients enabling more selective—and more effective—treatments. 4. Invite and introduce the next generation of young investigators to the field of TMD and comorbid pain conditions and to the basic and clinical research challenges/opportunities they represent. 5. Develop recommendations for the scientific community and NIH which will advance our understanding of how applications in precision medicine would be applied to TMD and comorbid chronic pain conditions.

项目概要 颞下颌关节协会第八次科学会议，精准医学如何应用于 颞下颌关节紊乱及其合并症？，定于 2016 年 9 月 11 日至 13 日在 位于马里兰州贝塞斯达的美国实验生物学会联合会会议中心。这 召开这次会议的必要性是由几个关键问题驱动的：首先，估计有 3600 万人受到影响 在美国，颞下颌关节紊乱病 (TMD) 是造成这种疾病的主要原因，其中大多数是育龄妇女 随之而来的身体、心理和经济负担。其次，仍然缺乏 对这些病症的病因、诊断、合并症和治疗的科学理解。第三， TMD 代表一种慢性疼痛状况，是一系列常见疼痛状况之一， 经常同时发生并且主要影响女性。 2016 年会议的重点是如何 精准医学可以为许多患者提供 TMD 和共​​存疼痛状况的治疗信息 经验。目前的诊断和治疗方法并不能反映当前的科学状况，而且还存在不足 满足有症状患者的需求。精准医疗技术在TMD及其治疗中的应用 合并症将使医疗服务提供者能够根据以下标准更准确地将 TMD 患者分为亚组： 特定的诊断标准，并导致量身定制的、更成功的治疗方法，以减轻他们的痛苦和痛苦。 演讲和讨论将重点关注获得精确分子和表型的挑战 重复、高效地对数千名患者进行测量。挑战解决方法 分析和整合来自多种模式的大数据集，例如临床测量、成像数据、 DNA 序列变异和表观遗传图谱将得到解决。会议将邀请关键科学 领导者、NIH 代表和患者倡导者，并将制定建议以推进研究 这个领域。会议的具体目标是： 1. 召集科学家探讨如何应用“精准医学”来推进诊断和治疗 针对 TMD 患者亚群的独特病理学和共病疼痛状况的治疗。 2. 评估精准医学可以开展哪些类型的研究以及如何汇总“N- of-1 试验”可以提供有关如何改善这些疼痛患者的治疗的信息。 3. 确定哪些生理和临床测试（遗传、神经、微生物学等）最有效 描述 TMD 患者子集的特征，从而实现更有选择性、更有效的治疗。 4. 邀请并介绍下一代年轻研究者进入 TMD 和共​​病疼痛领域 条件以及它们所代表的基础和临床研究挑战/机遇。 5. 为科学界和 NIH 制定建议，以增进我们对 精准医学的应用如何应用于 TMD 和共​​病慢性疼痛病症。