How Can Precision Medicine be Applied to Temporomandibular Disorders and its Comorbidities?

精准医学如何应用于颞下颌关节疾病及其合并症？

• 批准号: 9193954
• 负责人: Allen W Cowley
• 金额: $ 3.1万
• 依托单位: TMJ ASSOCIATION
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-09-01 至 2017-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9193954
• 关键词: Address; Advocate; Affect; Age; American; Basic Science; Behavioral; Biology; Biomedical Research; Body part; Caring; Clinical; Clinical Research; Communities; Comorbidity; Complex; DNA Sequence; Data; Data Set; Diagnosis; Diagnostic; Disease; Epigenetic Process; Etiology; Funding; Genes; Genetic screening method; Goals; Government; Healthcare; Image; Individual; Lead; Maryland; Measurement; Mediating; Methods; Modality; Molecular; Neurologic; Onset of illness; Organ; Outcomes Research; Pain; Pathology; Patient Participation; Patient Representative; Patient-Focused Outcomes; Patients; Physiological; Precision Medicine Initiative; Prevention; Provider; Recommendation; Research; Research Institute; Research Personnel; Schedule; Science; Scientist; Societies; Subgroup; Technology; Temporomandibular Joint; Temporomandibular Joint Disorders; Testing; United States National Institutes of Health; Variant; Vision; Woman; child bearing; chronic pain; chronic widespread pain; effective therapy; experience; falls; improved; individualized medicine; meetings; new technology; next generation; precision medicine; psychologic; sex; symposium

PROJECT SUMMARY The Eighth Scientific Meeting of The TMJ Association, How Can Precision Medicine be applied to Temporomandibular Disorders and its Comorbidities?, is scheduled to be held on September 11-13, 2016 at the Federation of American Societies for Experimental Biology Conference Center in Bethesda, Maryland. The need for this meeting is driven by several critical issues: First, there are an estimated 36 million people affected by temporomandibular disorders (TMD) in the US, the majority being women in their childbearing years with consequential physical, psychological and financial burdens. Second, there continues to be a dearth of scientific understanding of the etiology of these conditions, their diagnosis, comorbidities and treatment. Third, TMD represents a chronic pain condition, which is one among a cluster of prevalent pain conditions that frequently co-occur and predominantly affect women. The 2016 meeting is focused on how methods of Precision Medicine can inform the treatment of TMD and the comorbid pain conditions so many patients experience. Current diagnostics and treatments do not reflect the current state of the science and fall short in meeting the needs of symptomatic patients. The application of Precision Medicine technology to TMD and its comorbidities will enable providers to more accurately classify TMD patients into subgroups according to specific diagnostic criteria and lead to tailored, more successful treatments to relieve their pain and suffering. Presentations and discussions will focus on the challenges of obtaining precise molecular and phenotypic measurements from thousands of patients, repeatedly and efficiently. Challenges addressing methods to analyze and integrate large data sets from multiple modalities such as clinical measurements, imaging data, DNA sequence variants, and epigenetic profiles will be addressed. The meeting will engage key scientific leaders, NIH representatives and patient advocates and will develop recommendations to advance research in this field. The Specific Aims of the conference are to: 1. Convene scientists to explore how “precision medicine” can be applied to advance the diagnostics and treatments of the unique pathologies of subsets of TMD patients and comorbid pain conditions. 2. To assess what kinds of studies could be mounted in precision medicine and how aggregated results of “N- of-1 trials” can provide information on how to improve treatment of patients with these pain conditions. 3. Determine which physiological and clinical tests (genetic, neurological, micobiomic, etc.) can best characterize subsets of TMD patients enabling more selective—and more effective—treatments. 4. Invite and introduce the next generation of young investigators to the field of TMD and comorbid pain conditions and to the basic and clinical research challenges/opportunities they represent. 5. Develop recommendations for the scientific community and NIH which will advance our understanding of how applications in precision medicine would be applied to TMD and comorbid chronic pain conditions.

项目摘要 TMJ协会第八届科学会议，精准医学如何应用于 颞下颌关节紊乱病及其合并症？，定于2016年9月11日至13日在 位于马里兰州贝塞斯达的美国实验生物学学会联合会会议中心。的 有几个关键问题促使我们需要召开这次会议：首先，估计有3600万人受到影响 颞下颌关节紊乱病（TMD）在美国，大多数是妇女在他们的生育年龄， 由此产生的身体、心理和经济负担。第二，仍然缺乏 科学地了解这些疾病的病因、诊断、合并症和治疗。第三、 TMD代表一种慢性疼痛状况，它是一组普遍的疼痛状况之一， 经常同时发生，主要影响女性。2016年会议的重点是如何 精准医学可以告知TMD的治疗和许多患者的共病疼痛状况 体验.目前的诊断和治疗不能反映科学的现状， 满足有症状患者的需求。精准医学技术在TMD中的应用及其发展前景 合并症将使供应商能够更准确地将TMD患者分为亚组， 具体的诊断标准，并导致量身定制，更成功的治疗，以减轻他们的痛苦和痛苦。 演讲和讨论将集中在获得精确的分子和表型的挑战， 重复和有效地对数千名患者进行测量。解决方法方面的挑战， 分析和整合来自多种模态的大型数据集，例如临床测量，成像数据， DNA序列变异，和表观遗传概况将得到解决。会议将邀请关键科学家 领导人，NIH代表和患者倡导者，并将制定建议，以推进研究， 该领域会议的具体目标是： 1.召集科学家探讨如何应用“精准医学”来推进诊断， TMD患者亚群的独特病理和共病疼痛状况的治疗。 2.为了评估什么样的研究可以安装在精准医学和如何聚合的结果“N- “1个试验”可以提供如何改善这些疼痛患者治疗的信息。 3.确定哪些生理和临床测试（遗传学，神经学，微生物组学等）最能 描述TMD患者的特征，使治疗更具选择性和更有效。 4.邀请并介绍下一代年轻的研究人员到TMD和共病疼痛领域 条件以及它们所代表的基础和临床研究挑战/机遇。 5.为科学界和NIH提出建议，这将促进我们对 精准医疗的应用将如何应用于TMD和共病慢性疼痛疾病。