2015 Stress Proteins in Growth, Development and Disease GRC

 描述（由申请人提供）：细胞蛋白质组持续暴露于各种毒性应激。这些包括外部应力，例如升高的温度、辐射损伤和药理学试剂以及在细胞增殖、分化、炎症和衰老期间遇到的生理应力。在所有生物体中，应激反应的诱导对于维持蛋白质稳态是必不可少的，并且应激反应的调节在寿命调节和与衰老相关的疾病如阿尔茨海默氏症、帕金森氏症和亨廷顿氏症中起关键作用。2015年戈登会议“生长，发育和疾病中的应激蛋白质”正在成为该研究领域最令人兴奋和最重要的会议之一。它将突出该领域的许多前沿进展，强调广泛的主题，包括与压力传感，信号传导和基因表达有关的令人兴奋的发展，蛋白质折叠和构象疾病，压力基因在代谢，生长和发育中的作用，压力基因对感染和病理生理状态的调节，压力的细胞生物学以及压力在衰老中的作用。本次会议是该系列的第八次会议，将于7月5日至10日在意大利卢卡的Il Ciocco度假村举行。本次会议的主席是Ursula Jakob博士（密歇根大学，安阿伯，MI），副主席是Kevin Morano博士（德克萨斯州休斯顿的UT健康医学院）。在2015年的计划中，我们努力改善我们在演讲者代表性方面的性别平衡，在接受我们邀请发表演讲的31位国际公认的演讲者中，35%是女性科学家。我们还在上午会议结束时留出16个延长（即12分钟）和20个新颖的两分钟海报演讲的时间，让研究人员有机会展示他们研究的主要发现，并吸引参与者观看他们的海报。将优先考虑年轻的科学家和代表性不足的群体。会议时间表也准备，以确保压力生物学和不同的模型系统中的新的和新兴的主题得到平等的代表。此外，会议出席人数将限制在150人以内，以促进有效的互动和讨论。的 正式的科学计划加上非正式的圆桌讨论将促进新信息的传播和新合作的形成，这对于更深入地了解应激蛋白在人类健康，衰老和疾病中的多方面作用是非常宝贵的。

 DESCRIPTION (provided by applicant): The cellular proteome is constantly exposed to a wide variety of toxic stresses. These include external stresses, such as elevated temperatures, radiation damage and pharmacological agents as well as physiological stresses encountered during cellular proliferation, differentiation, inflammation and aging. In all organisms, inductionof the stress response is essential for the maintenance of protein homeostasis and modulation of the stress response plays a critical role in life-span regulation and aging-related diseases such as Alzheimer's, Parkinson's and Huntington's disease. The 2015 Gordon Conference on "Stress Proteins in Growth, Development & Disease" is shaping up to be one of the most exciting and important meetings in this research area. It will highlight the many cutting edge advances in the field, emphasizing a broad range of topics, including exciting developments related to stress sensing, signaling, and gene expression, diseases of protein folding and conformation, roles of stress genes in metabolism, growth and development, stress gene modulation of infection and pathophysiological states, the cell biology of stress, and the roles of stress in aging. This conference, which is the eighth in this series, will be held July 5th-10th at the Il Ciocco Resort n Lucca, Italy. The chair of this meeting is Dr. Ursula Jakob (University of Michigan, Ann Arbor, MI) and the Vice Chair is Dr. Kevin Morano (UT Health Medical School in Houston, Texas). For the 2015 program, we have striven to improve our gender balance in the speaker representation, and of the 31 internationally recognized speakers who have accepted our invitation to give talks, 35% are women scientists. We also set aside time for 16 extended (i.e. 12 minutes) and 20 novel, two-minute poster talks at the end of the morning session to give investigators a chance to present key findings from their research and attract participants to their posters. Preference will be given to younger scientists and to those from under-represented groups. The meeting schedule is also prepared to ensure that new and emerging themes in stress biology and different model systems are equally represented. In addition, meeting attendance will be limited to 150 to facilitate effective interactions and discussions. The formal scientific program together with more informal round-table discussion will enhance the dissemination of new information and the formation of new collaborations, which are invaluable for deeper understanding of the versatile roles of stress proteins in human health, aging and disease.