Molecular Mechanisms of Disease

 描述(由申请人提供)：内布拉斯加-林肯大学建议建立分子机制疾病(MMOD)博士前培训计划，以提供以分子相互作用和化学转化为中心的生物医学研究方面的创新培训和职业发展。该计划弥补了NIH细胞、生化和分子科学培训重点的九个州之间的差距。该计划的目标是培养优秀的新科学家，他们在协作的多学科团队中工作，使用量化方法研究疾病机制，最终产生切实的预防和治疗策略。为了实现这一目标，该计划将招募对人类疾病的根本原因具有浓厚兴趣的高质量、有动力的博士前实习生，并让他们参与有指导的尖端研究。其具体目标是：(1)每年为16名博士前学员(8名由NIH支持，8名由机构支持)提供严格的课程和创新的合作研究机会，以成为人类疾病机械研究方面的专家；(2)培养一种互动的培训环境，强调发展专业网络、资历、领导力以及书面和口头沟通方面的杰出技能；(3)支持导师在四个机械性疾病研究重点领域的合作培训努力：分子信号、代谢完整性、氧化应激和疾病微环境。NIH将为有本科实验室经验的学员提供为期两年的五年计划，并在T32培训期间之前进行一年的研究生水平课程学习。新学员的选择将是竞争性的，基于良好的学术记录、研究进展和潜力，以及为创新论文研究弥合学科界限的原创合作提案。MMOD指导团队跨越七个系和三个学院，包括28名教职员工，他们都在生物医学研究资助和研究生指导方面拥有丰富的历史。学员将在第一年完成四次研究轮换，然后选择代表四个重点领域之一的教师导师。学员将选择灵活的核心课程：代谢功能和功能障碍，一门来自认可的核心的定量生物学课程，以及两门来自认可的核心的高分子课程。通过这些课程，他们将接受有关写作技巧、科学写作和研究的正式培训。 和期刊文章演示。他们还将获得独特的创业学习和教学机会，并将组织以该计划外部咨询委员会会议为中心的年度研讨会。MMOD计划将提供一个框架，使受训人员能够建立广泛的知识库；积极寻求研究合作；产生原始发表研究的杰出记录；并培养演示、提案撰写和领导技能，使他们作为专注于疾病发展机制的独立研究人员，为未来的卓越表现奠定基础。

 DESCRIPTION (provided by applicant): The University of Nebraska-Lincoln proposes to establish the Molecular Mechanisms of Disease (MMoD) predoctoral training program to provide innovative training and career development in biomedical research centered on molecular interactions and chemical transformations. The program bridges a nine-state gap in the NIH training focus of Cellular, Biochemical, and Molecular Sciences. The goal of the program is to develop outstanding new scientists who work in collaborative multi-disciplinary teams to research disease mechanisms using quantitative approaches that ultimately yield tangible strategies for prevention and therapy. To accomplish this goal, the program will recruit high-quality, motivated predoctoral trainees with a strong interest in the underlying causes of human disease and engage them in mentored, cutting-edge research. The specific aims are to: (1) Provide a rigorous curriculum and innovative, collaborative research opportunities for sixteen predoctoral trainees per year (eight NIH-supported and eight institutionally supported) to become experts in the mechanistic study of human disease; (2) Cultivate an interactive training environment that emphasizes development of outstanding skills in professional networking, grantsmanship, leadership, and written and oral communication; (3) Support collaborative training efforts of mentors in four areas of mechanistic disease research emphasis: molecular signaling, metabolic integrity, oxidative stress, and disease microenvironment. NIH support will span two years of a five-year program for trainees with undergraduate laboratory experience and one year of graduate-level coursework prior to the T32 training period. Selection of new trainees will be competitive, based on strong academic record, research progress and potential, and an original collaborative proposal bridging disciplinary boundaries for innovative thesis research. The MMoD mentoring team spans seven departments and three colleges and includes 28 faculty members, all with strong histories in biomedical research funding and graduate student mentoring. Trainees will complete four research rotations in year 1 before choosing a faculty mentor representing one of the four emphasis areas. Trainees will take a flexible core curriculum: Metabolic Function and Dysfunction, one Quantitative Biology course from an approved core, and two Macromolecules courses from an approved core. Through these courses, they will receive formal training in grantsmanship, scientific writing, and research and journal article presentations. They will also be provided with unique entrepreneurial learning and teaching opportunities and will organize an annual symposium centered on the meeting of the program's external advisory committee. The MMoD program will provide a framework that enables trainees to assemble a broad knowledge base; actively seek research collaborations; produce an outstanding record of original published research; and develop presentation, proposal-writing, and leadership skills that will position them for future excellence as independent researchers focused on mechanisms of disease progression.