Redox Biology Center

氧化还原生物学中心（RBC）成立于2002年，是内布拉斯加大学林肯分校（UNL）和内布拉斯加大学医学中心（UNMC）的研究人员之间的跨学科合作伙伴关系，现已发展成为一个全国性的、国际公认的卓越项目，致力于解决与疾病作斗争和改善人类健康至关重要的基本问题。在第一阶段和第二阶段，RBC实现了增强内布拉斯加州生物医学研究能力的主要目标，通过创建1)强大研究项目的战略联系基础设施，2)指导有才华的初级教师独立成功的计划，3)支持代谢组学/蛋白质组学和光谱/生物成像的核心研究设施，以及4)创新教育活动。因此，RBC培养了一批资金充足且富有成效的教职员工，他们的研究在氧化还原生物学方面产生了新的见解，这些见解对神经退行性疾病、心血管健康、白内障和癌症具有重要意义。第二阶段资金的结束使RBC果断地朝着其长期愿景迈进，即成为一个自我维持的卓越研究中心，负责提供国际领导力和优秀的研究资源，使其他IDeA项目和整个科学界受益。第三阶段的资金将允许RBC通过提供必要的资金支持有价值的多机构研究试点项目来实现这一总体目标，这些项目建立必要的跨学科合作，以维持一个强大的中心，并在保持和扩大RBC的研究核心设施并促进教育和推广的同时竞争项目类型的资金。这三个组成部分——研究试点项目计划、核心设施（包括强大的行政核心）和强大的教育/外展计划，将使加拿大皇家银行实现第三阶段申请中提出的具体目标：1)提高研究能力、创新和校外资金；2)加强氧化还原生物学的科研培训和教育；3)从IDeA项目资助中毕业，成为氧化还原生物学领域一个自我可持续发展的卓越研究中心。

Founded in 2002 as an interdisciplinary partnership between researchers at the University of Nebraska-Lincoln (UNL) and the University of Nebraska Medical Center (UNMC), the Redox Biology Center (RBC) has grown into a nationally visible and internationally recognized program of excellence addressing fundamental questions crucial to fighting disease and improving human health. During Phases I and II, the RBC achieved its primary objective of enhancing Nebraska's biomedical research capacity through the creation of 1) a strategically linked infrastructure of strong research programs, 2) a program for mentoring talented junior faculty to independent success, 3) support for core research facilities in metabolomics/proteomics and spectroscopy/bioimaging, and 4) innovative educational activities. As a result, the RBC has developed a cadre of well-funded and productive faculty members conducting research leading to new insights in redox biology that have important implications in neurodegenerative diseases, cardiovascular health, cataracts, and cancer. Reaching the end of Phase II funding positions the RBC to move decisively toward its long-term vision of becoming a self-sustaining center of research excellence charged with providing international leadership and outstanding research resources benefiting other IDeA programs and the scientific community at large. Phase III funding will allow the RBC to attain this overarching goal by providing funds necessary to support meritorious multi-institutional research pilot projects that build the interdisciplinary collaborations necessary to maintain a strong center and compete for program project type funding while maintaining and expanding the RBC's research core facilities and promoting education and outreach. These three components - research pilot project program, core facilities (including a strong administrative core), and strong education/outreach programs, will allow the RBC to accomplish the specific aims set forth in this Phase III application: 1) Increase research capabilities, innovation, and extramural funding; 2) Strengthen research training and education in redox biology; and 3) Graduate from IDeA program funding as a self-sustainable center of research excellence in redox biology.