Molecular Mechanisms of Disease

该提案旨在为疾病的分子机制（MMoD）博士前培训计划提供资金， 内布拉斯加大学林肯分校MMoD计划解决了细胞的NIH培训重点， 生物化学和分子科学通过提供生物医学领域的高级培训和职业发展， 研究主要集中在分子间的相互作用和化学转化。该计划的目标是 培养杰出的新科学家，他们在合作的多学科团队中研究疾病 使用定量方法的机制，最终产生切实的预防和治疗战略。 为了实现这一目标，该计划将招募高素质，积极主动的博士前学员， 对人类疾病的根本原因感兴趣，并让他们参与指导的尖端研究。的 MMoD计划将（1）提供严格的课程和创新，合作研究的机会， 每年六名博士前学员（NIH支持）成为人类机械研究专家 （2）营造互动的培训环境，使学员能够发展以下方面的专业技能： 沟通，领导力，提案写作，奖学金，创业和教学;和3）建立一个 来自不同角度的一批学员，他们有知识和能力在 不同的学科在他们未来的职业生涯作为博士科学家。MMoD计划提供协作 在分子信号传导，代谢完整性，氧化性等领域的机械性疾病研究的培训 应激和氧化还原生物学以及疾病微环境。MMoD指导团队跨越七个 部门和三个学院，包括32名教师，从早期阶段，以建立调查 在生物医学研究资助和研究生指导方面有着悠久的历史。学员将进行四次 在选择教师导师之前，在第一年进行研究轮换，并将得到NIH T32资金的支持， 从五年计划的第二年开始的两年。为国家卫生研究院支助挑选新受训人员 将具有竞争力，基于良好的学术记录，研究进展和潜力，以及原创性 合作建议弥合学科界限的创新论文研究。学员将参加一个 灵活的核心课程，包括代谢功能和功能障碍课程，以及定量 生物课程和两个大分子课程从批准的核心。虽然这些课程和MMoD 培训模块，学生将获得循证教育，定量和批判性分析， 以及研究的严谨性和可重复性。他们还将有机会获得相关的专业经验， 知识产权和制药行业，为潜在的职业选择做准备。MMoD 该计划提供了一个框架，使学员能够获得广泛的知识基础;积极寻求研究 合作;产生原始发表研究的杰出记录;并开发演示文稿， 提案写作和领导技能，这将使他们成为未来独立研究人员的卓越人才。

This proposal seeks funding for the Molecular Mechanisms of Disease (MMoD) predoctoral training program at the University of Nebraska-Lincoln. The MMoD program addresses the NIH training focus of Cellular, Biochemical, and Molecular Sciences by providing advanced training and career development in biomedical research centered on molecular interactions and chemical transformations. The goal of the program is to develop outstanding new scientists who work in collaborative multi-disciplinary teams to research disease mechanisms using quantitative approaches that ultimately yield tangible strategies for prevention and therapy. To accomplish this goal, the program will recruit high-quality, motivated predoctoral trainees with a strong interest in the underlying causes of human disease and engage them in mentored, cutting-edge research. The MMoD program will (1) Provide a rigorous curriculum and innovative, collaborative research opportunities for six predoctoral trainees per year (NIH-supported) to become experts in the mechanistic study of human disease; (2) Cultivate an interactive training environment that enables trainees to develop professional skills in communication, leadership, proposal-writing, scholarship, entrepreneurship, and teaching; and 3) Build a cohort of trainees from diverse perspectives that have the knowledge and ability to work at the crossroads of different disciplines in their future careers as PhD scientists. The MMoD program provides collaborative training in mechanistic disease research in the areas of molecular signaling, metabolic integrity, oxidative stress and redox biology, and disease microenvironment. The MMoD mentoring team spans seven departments and three colleges and includes 32 faculty members from early-stage to established investigators with strong histories in biomedical research funding and graduate student mentoring. Trainees will conduct four research rotations in year 1 before choosing a faculty mentor, and will be supported by NIH T32 funding for up to two years beginning in the second year of their five-year program. Selection of new trainees for NIH support will be competitive, based on strong academic record, research progress and potential, and an original collaborative proposal bridging disciplinary boundaries for innovative thesis research. Trainees will take a flexible core curriculum that includes a course on Metabolic Function and Dysfunction, and a quantitative biology course and two macromolecules courses from an approved core. Though these courses and MMoD training modules, students will acquire skills in evidence-based education, quantitative and critical analysis, and, rigor and reproducibility in research. They will also have opportunities for professional experiences related to intellectual property and the pharmaceutical industry in preparation for potential career options. The MMoD program provides a framework that enables trainees to gain a broad knowledge base; actively seek research collaborations; produce an outstanding record of original published research; and develop presentation, proposal-writing, and leadership skills that will position them for future excellence as independent researchers.