Subcortical auditory feedback mechanisms in speech: Function and structure

言语中的皮层下听觉反馈机制：功能和结构

• 批准号: 9188910
• 负责人: Kevin Richard Sitek
• 金额: $ 3.62万
• 依托单位: HARVARD MEDICAL SCHOOL
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-09-01 至 2018-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9188910
• 关键词: Accounting; Affect; Algorithms; Animals; Apraxias; Attention; Auditory; Auditory Brain Stem Implants; Auditory Brainstem Responses; Auditory Perceptual Disorders; Auditory area; Auditory system; Autistic Disorder; Brain; Brain Stem; Brain imaging; Cell Nucleus; Chiroptera; Clinical; Cochlear Implants; Cochlear Nerve; Cochlear nucleus; Communication impairment; Complex; Data; Development; Developmental Stuttering; Developmental apraxia; Diffusion; Diffusion Magnetic Resonance Imaging; Disease; Ear; Effectiveness; Efferent Neurons; Electroencephalography; Feedback; Fiber; Functional Magnetic Resonance Imaging; Future; Geniculate body structure; Hearing; Hearing problem; Human; Imaging Device; Imaging Techniques; Implant; Individual; Inferior; Inferior Colliculus; Investigation; Labyrinth; Linguistics; Location; Measures; Medial; Mental disorders; Methods; Midbrain structure; Motor; Neurons; Noise; Organ; Participant; Pathway interactions; Peripheral; Process; Production; Pulvinar structure; Reporting; Research; Resolution; Role; Schizophrenia; Sensory; Sensory Process; Signal Transduction; Specificity; Speech; Speech Disorders; Speech Sound; Stimulus; Structure; Stuttering; Techniques; Testing; Thalamic Nuclei; Thalamic structure; Tinnitus; Training; Voice; abstracting; anatomical tracing; attenuation; auditory feedback; auditory pathway; base; connectome; effective therapy; in vivo; innovation; insight; motor control; motor disorder; novel; novel therapeutics; prevent; relating to nervous system; research study; response; sound; vocalization

Project Summary/Abstract    When we produce speech, the auditory system reduces its response to what it expects to hear based on the  motor plan. This allows the auditory system to remain vigilant of externally produced sounds while also  enabling it to detect errors between the expected and actual produced sounds. Disruption of this auditory  feedback mechanism during speech production has been implicated in speech disorders like persistent  developmental stuttering and apraxia of speech as well as in mental health disorders like autism and  schizophrenia. Previous research has suggested that much, but not all, of the auditory feedback comparison is  performed in auditory cortex. Other auditory feedback processing is likely performed by earlier subcortical  auditory structures, but the precise mechanisms and locations of this processing has not been explicitly  investigated. In this project, I propose three aims for investigating the structure and function of subcortical  auditory structures in auditory feedback processing. ​Aim 1 is to demonstrate the contribution of  subcortical auditory structures to general motor­induced suppression. ​Using two complementary brain  imaging techniques, we will test whether generating a sound by pressing a button results in decreased auditory  subcortical activity when compared to passive listening of those sounds. ​Aim 2 is to test speech­specific  subcortical auditory modulation by examining subcortical activity during speech formant feedback  perturbation​. In this experiment, we will alter how participants hear themselves while they speak. Using  high­resolution functional brain imaging, we will be able to see if differences between expected and actual  speech feedback cause more activity in subcortical auditory structures. ​Aim 3 is to describe the structural  connectivity between auditory structures and the auditory periphery using high­sensitivity  diffusion­weighted imaging​. This brain imaging technique allows us to infer how neuron bundles are  physically connected in the brain and extending out to the ear. Using existing data from a powerful new  imaging device, we will examine neural connections between specific auditory and motor structures in greater  detail than have been investigated before. We will also develop a new method to track the cochlear nerve from  the brainstem to the ear in order to help clinicians determine the best hearing implant for hearing­impaired  individuals. Overall, this project will provide high resolution brain imaging of subcortical auditory structures and  their role in comparing expected to actual self­generated sounds. Our results will help us understand how  faulty connections can contribute to speech and mental health disorders and will enable the development of  more effective therapies for such disorders in the future.

项目总结/文摘