Investigating human non-lemniscal inferior colliculus contributions to auditory learning with 7T MRI
使用 7T MRI 研究人类非丘系下丘对听觉学习的贡献
基本信息
- 批准号:10371381
- 负责人:
- 金额:$ 14.05万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2022
- 资助国家:美国
- 起止时间:2022-05-16 至 2027-04-30
- 项目状态:未结题
- 来源:
- 关键词:AcousticsAdultAnatomyAnimal ModelAuditoryAuditory areaAuditory systemBrainBrain regionCategoriesCell NucleusClinicalCochlear ImplantsCommunicationComplexDiffusion Magnetic Resonance ImagingDorsalEarElectrophysiology (science)EnvironmentFoundationsFrequenciesFunctional Magnetic Resonance ImagingFutureHearing problemHumanHuman CharacteristicsImageImaging TechniquesImplantIndividualInferior ColliculusInvestigationLearningLocationMagnetic Resonance ImagingMapsMediatingMentorsMethodologyMethodsMidbrain structureParticipantPathway interactionsPatternPhasePlayProcessPropertyProtocols documentationResearchResearch Project GrantsResolutionRoleRouteScalp structureSelf-Help DevicesSensorineural Hearing LossSensory DisordersSignal TransductionSpecificitySpeechSpeech SoundStimulusStructureSystemTestingTimeTinnitusTissuesTrainingauditory pathwayauditory processingauditory thalamusbaseclinical applicationclinically relevantcontrast imaginghearing impairmentin vivoin vivo imagingmagnetic fieldneural implantnext generationnovelprogramsrelating to nervous systemresponsesoundtheoriestractographywhite matter
项目摘要
PROJECT SUMMARY
Human inferior colliculus (IC) plays a critical role in auditory processing. However, the anatomy and
function of the lemniscal (primary) and non-lemniscal subdivisions of IC in living humans are poorly understood
due to the technical challenges of in vivo magnetic resonance imaging (MRI) of the small midbrain structures
deep within the brain. In particular, despite predominant top-down and bottom-up theories of auditory learning,
the neural systems underlying human speech category learning is unknown. Recent advances in MRI acquisition
open the door for focused investigations into the anatomy and functional processing of human auditory midbrain.
My research environment and mentor team will allow me to gain the expertise necessary to independently
investigate the subcortical auditory system in living humans using MRI.
In this project, we will use ultra-high field 7T MRI to quantify anatomical midbrain tissue contrast in a sub-
structure dependent manner. We will also map the structural connections from each IC subdivision throughout
the auditory system. Quantifying the specific anatomical MRI contrasts and connectivity patterns in living human
midbrain will enable future clinical applications for investigating hearing disorders such as sensorineural hearing
loss and tinnitus.
A possible functional role for non-lemniscal IC is in learning novel speech sound categories. We will
collect 7T functional MRI at multiple timepoints during a sound-to-category learning program to assess the
contribution of IC and auditory cortex to sound category learning. Our results will elucidate whether novel
categories are learned via cortically driven plasticity (cortex represents categorical features at an earlier stage
than IC’s relevant acoustic enhancement) or stimulus feature enhancement (IC and cortex have similar time
courses of plasticity).
Existing methods for probing auditory processing, such as the scalp-recorded frequency following
response (FFR), have both subcortical and cortical generators, but their relative contributions throughout the
auditory learning process have not been investigated in humans. Participants in our sound-to-category learning
paradigm will also undergo FFR recordings. Using representational similarity analysis, we will assess whether
sound category feature representation in FFRs primarily follows that of auditory cortex or that of IC, suggesting
the relative contribution of each generator at each phase of sound-to-category learning.
This project implements state-of-the-art anatomical and functional 7T MRI techniques to quantify
foundational characteristics of the human inferior colliculus, a key but poorly investigated subcortical auditory
structure. The methods we utilized can be adapted to investigate other small, deep structures throughout the
human auditory system and will enhance our understanding of IC contributions to tinnitus and optimal placement
of auditory brain implants for individuals with sensorineural hearing loss.
项目概要
人类下丘(IC)在听觉处理中起着至关重要的作用。然而,解剖学和
IC 的丘系(初级)和非丘系细分在活人中的功能知之甚少
由于小型中脑结构的体内磁共振成像(MRI)的技术挑战
大脑深处。特别是,尽管听觉学习的自上而下和自下而上的理论占主导地位,
人类语音类别学习背后的神经系统尚不清楚。 MRI 采集的最新进展
为集中研究人类听觉中脑的解剖学和功能处理打开了大门。
我的研究环境和导师团队将使我获得独立所需的专业知识
使用 MRI 研究活人的皮层下听觉系统。
在这个项目中,我们将使用超高场 7T MRI 来量化亚组中的解剖中脑组织对比度
结构依赖方式。我们还将绘制整个 IC 细分领域的结构连接图
听觉系统。量化活人的特定解剖 MRI 对比和连接模式
中脑将使未来的临床应用能够用于研究听力障碍,例如感音神经性听力
损失和耳鸣。
非丘系 IC 的一个可能的功能作用是学习新的语音类别。我们将
在声音到类别学习计划期间收集多个时间点的 7T 功能 MRI,以评估
IC 和听觉皮层对声音类别学习的贡献。我们的结果将阐明是否新颖
类别是通过皮质驱动的可塑性学习的(皮质代表早期阶段的分类特征
比 IC 相关的声学增强)或刺激特征增强(IC 和皮层具有相似的时间
可塑性课程)。
现有的探测听觉处理的方法,例如头皮记录的频率跟踪
响应(FFR),同时具有皮质下和皮质发生器,但它们在整个过程中的相对贡献
尚未对人类的听觉学习过程进行过研究。声音到类别学习的参与者
范式也将进行 FFR 录音。使用代表性相似性分析,我们将评估是否
FFR 中的声音类别特征表示主要遵循听觉皮层或 IC 的特征表示,表明
每个生成器在声音到类别学习的每个阶段的相对贡献。
该项目采用最先进的解剖和功能 7T MRI 技术来量化
人类下丘的基本特征,一个关键但研究不足的皮层下听觉
结构。我们使用的方法可以适用于研究整个宇宙中的其他小型深层结构
人类听觉系统,将增强我们对 IC 对耳鸣的贡献和最佳放置的理解
为感音神经性听力损失患者进行听觉脑植入。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Kevin Richard Sitek其他文献
Kevin Richard Sitek的其他文献
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{{ truncateString('Kevin Richard Sitek', 18)}}的其他基金
Investigating human non-lemniscal inferior colliculus contributions to auditory learning with 7T MRI
使用 7T MRI 研究人类非丘系下丘对听觉学习的贡献
- 批准号:
10928960 - 财政年份:2022
- 资助金额:
$ 14.05万 - 项目类别:
Subcortical auditory feedback mechanisms in speech: Function and structure
言语中的皮层下听觉反馈机制:功能和结构
- 批准号:
9260686 - 财政年份:2016
- 资助金额:
$ 14.05万 - 项目类别:
Subcortical auditory feedback mechanisms in speech: Function and structure
言语中的皮层下听觉反馈机制:功能和结构
- 批准号:
9188910 - 财政年份:2016
- 资助金额:
$ 14.05万 - 项目类别:
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