Pharmacy Naloxone Distribution: Assessing a New Tool to Reduce Overdose Mortality
药房纳洛酮分布:评估降低用药过量死亡率的新工具
基本信息
- 批准号:9113804
- 负责人:
- 金额:$ 66.17万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2016
- 资助国家:美国
- 起止时间:2016-05-01 至 2021-01-31
- 项目状态:已结题
- 来源:
- 关键词:AccountingAddressAdultAnalgesicsCessation of lifeCommunitiesCommunity PharmacyCountryDrug ControlsDrug PrescriptionsEmergency SituationEnsureFamily memberFriendsHealthHealth PersonnelHeroinIndividualInjuryInterdisciplinary StudyLicensingLifeMassachusettsMethodsModelingNaloxoneNamesNarcotic AntagonistsNatural experimentOpioidOverdosePersonsPharmaceutical PreparationsPharmacistsPharmacy facilityPhysiciansPoisoningPoliciesPrivate SectorPublic HealthPublic SectorResearchResearch DesignRhode IslandRiskSiteStatutes and LawsTrainingUnited StatesVehicle crashagedbasecommunity organizationscost effectivedesignemergency service responderinnovationmortalitynon-drugnoveloverdose deathoverdose preventionprescription pain relieverprogramspublic health interventionpublic health relevanceresponsetherapy designtoolwillingness
项目摘要
DESCRIPTION (provided by applicant): Drug overdose is the leading cause of injury death among adults aged 25 to 64 years in the United States. The number of fatal overdoses involving opioid pain relievers nearly quadrupled between 1999 and 2013, and fatal overdoses related to heroin almost tripled between 2010 and 2013. Public health interventions designed to reduce opioid overdose deaths are urgently needed. Naloxone is an opioid antagonist that "reverses" opioid overdoses. Increased access to naloxone has been shown to reduce opioid overdose mortality; however, naloxone is a prescription drug, which limits opportunities to expand its distribution. In March 2014, Massachusetts established an innovative program that allows the issuance of naloxone standing orders (NSO) at community pharmacies. Under NSO, pharmacies can dispense naloxone to any individual at risk of having, or witnessing, an opioid overdose. Massachusetts is one of the first states to implement a pharmacy-based naloxone distribution program on a broad scale, but a growing number of states are passing legislation to authorize these programs. Accordingly, Massachusetts represents an important and timely "natural experiment" in expanding naloxone access through community pharmacies. This study will use a multiphase mixed methods research design to assess the implementation and impact of the Massachusetts NSO program. Specifically, this study will (1) characterize implementation of the Massachusetts NSO program and assess barriers and facilitators to pharmacy participation and proper dispensing; (2) examine the acceptability of pharmacy-based naloxone dispensing to illicit opioid users and potential overdose bystanders and identify factors that would increase acceptance for these two groups; and (3) assess the impact of the pharmacy NSO program on overdose mortality. At the conclusion of our study, we will have generated a comprehensive understanding of the factors that influence the implementation and impact of one of the first statewide pharmacy-based naloxone dispensing programs in the United States. Our findings will be of considerable value to the growing number of states considering and/or implementing NSO programs as part of their overall strategy to reduce the public health burden of opioid overdose mortality.
描述(由申请人提供):药物过量是美国25至64岁成年人受伤死亡的主要原因。1999年至2013年期间,涉及阿片类止痛药的致命过量数量几乎翻了两番,2010年至2013年期间,与海洛因有关的致命过量几乎翻了三倍。迫切需要旨在减少阿片类药物过量死亡的公共卫生干预措施。纳洛酮是一种阿片类拮抗剂,可以“逆转”阿片类药物过量。增加获得纳洛酮已被证明可以降低阿片类药物过量死亡率;然而,纳洛酮是一种处方药,这限制了扩大其分布的机会。2014年3月,马萨诸塞州制定了一项创新计划,允许在社区药店发放纳洛酮长期订单(NSO)。在NSO下,药房可以向任何有或目睹阿片类药物过量风险的个人分发纳洛酮。马萨诸塞州是最早大规模实施以药房为基础的纳洛酮分销计划的州之一,但越来越多的州正在通过立法授权这些计划。因此,马萨诸塞州代表了一个重要和及时的“自然实验”,通过社区药房扩大纳洛酮的获得。本研究将采用多阶段混合方法研究设计,以评估马萨诸塞州国家统计局计划的实施和影响。具体而言,本研究将(1)描述马萨诸塞州NSO项目的实施情况,并评估药房参与和适当分配的障碍和促进因素;(2)检查基于药房的纳洛酮分配给非法阿片类药物使用者和潜在过量旁观者的可接受性,并确定增加这两个群体接受度的因素;和(3)评估药房NSO计划对过量死亡率的影响。在我们的研究结束时,我们将全面了解影响美国第一个以全州药房为基础的纳洛酮配药计划的实施和影响的因素。我们的研究结果将对越来越多的州考虑和/或实施国家统计局计划作为其整体战略的一部分,以减少阿片类药物过量死亡的公共卫生负担具有相当大的价值。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Robin A Pollini其他文献
Robin A Pollini的其他文献
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{{ truncateString('Robin A Pollini', 18)}}的其他基金
Identifying Stigma Reduction Targets in the Context of an Appalachian HIV Outbreak
在阿巴拉契亚艾滋病毒爆发的背景下确定减少耻辱的目标
- 批准号:
10415554 - 财政年份:2022
- 资助金额:
$ 66.17万 - 项目类别:
Identifying Stigma Reduction Targets in the Context of an Appalachian HIV Outbreak
在阿巴拉契亚艾滋病毒爆发的背景下确定减少耻辱的目标
- 批准号:
10670313 - 财政年份:2022
- 资助金额:
$ 66.17万 - 项目类别:
Pharmacy Naloxone Distribution: Assessing a New Tool to Reduce Overdose Mortality
药房纳洛酮分布:评估降低用药过量死亡率的新工具
- 批准号:
9629678 - 财政年份:2017
- 资助金额:
$ 66.17万 - 项目类别:
Pharmacy Naloxone Distribution: Assessing a New Tool to Reduce Overdose Mortality
药房纳洛酮分布:评估降低用药过量死亡率的新工具
- 批准号:
10092988 - 财政年份:2017
- 资助金额:
$ 66.17万 - 项目类别:
OTC Syringe Sales to Prevent HIV in Underserved Areas of Inland California
销售非处方药注射器以预防加利福尼亚州内陆服务欠缺地区的艾滋病毒
- 批准号:
8466903 - 财政年份:2013
- 资助金额:
$ 66.17万 - 项目类别:
OTC Syringe Sales to Prevent HIV in Underserved Areas of Inland California
销售非处方药注射器以预防加利福尼亚州内陆服务欠缺地区的艾滋病毒
- 批准号:
8780622 - 财政年份:2013
- 资助金额:
$ 66.17万 - 项目类别:
OTC Syringe Sales to Prevent HIV in Underserved Areas of Inland California
销售非处方药注射器以预防加利福尼亚州内陆服务欠缺地区的艾滋病毒
- 批准号:
8601068 - 财政年份:2013
- 资助金额:
$ 66.17万 - 项目类别:
Defining the Role of Mexican Pharmacies in HIV Prevention-A Mixed Method Approach
定义墨西哥药房在艾滋病毒预防中的作用——混合方法
- 批准号:
8283008 - 财政年份:2007
- 资助金额:
$ 66.17万 - 项目类别:
Defining the Role of Mexican Pharmacies in HIV Prevention-A Mixed Method Approach
定义墨西哥药房在艾滋病毒预防中的作用——混合方法
- 批准号:
7497029 - 财政年份:2007
- 资助金额:
$ 66.17万 - 项目类别:
Defining the Role of Mexican Pharmacies in HIV Prevention-A Mixed Method Approach
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- 批准号:
7908794 - 财政年份:2007
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