UAB Vision Science Research Center

UAB视觉科学研究中心

• 批准号: 9153111
• 负责人: STEVEN J PITTLER
• 金额: $ 58.8万
• 依托单位: UNIVERSITY OF ALABAMA AT BIRMINGHAM
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-08-01 至 2021-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9153111
• 关键词: Affect; Age related macular degeneration; American; Animal Model; Area; Award; Biochemical; Biometry; Caliber; Cataract; Cells; Center Core Grants; Collaborations; Complement; Complex; Computer Analysis; Computer software; Computers and Advanced Instrumentation; Consensus; Core Facility; Core Grant; Custom; DNA; Devices; Diagnostic; Disease; Doctor of Philosophy; Electronics; Elements; Engineering; Equipment; Experimental Designs; Extramural Activities; Faculty; Focus Groups; Funding; Glaucoma; Goals; Grant; Growth; Hour; Human; Individual; Institution; Keratoconus; Lead; Mechanics; Modality; Molecular; Monitor; Myopia; Outcome; Participant; Phase; Phenotype; Physiological; Productivity; Proteins; Psychophysics; Publications; Quality of life; RNA; Request for Applications; Research; Research Activity; Research Design; Research Personnel; Research Project Grants; Research Support; Resource Sharing; Resources; Retina; Retinitis Pigmentosa; Scientific Inquiry; Scientist; Services; Statistical Data Interpretation; Structure; Surveys; Technology; Time; Tissues; Training; United States National Institutes of Health; Vision; Vision Disorders; Vision research; Visual Pathways; abstracting; analytical tool; career; computer program; computer science; cost; design; experience; experimental analysis; eye dryness; improved; instrument; instrumentation; meetings; novel; programs; ranpirnase; repaired; satisfaction; software development; success; synergism; tool; vision science; visual neuroscience

UAB Vision Science Research Center - Overall Core 7. Project Summary/Abstract In 1979, an NEI Core grant was first awarded to UAB. Over the next 35 years, the institution's continued commitment to growth resulted in a remarkable expansion in vision research. Participants have now increased from 13 in two departments to 23 in five departments, and there has been a concomitant increase in extramural funding. Eleven of the Core participants currently hold 14 eligble grants, another 7 have NEI new investigator status and are seeking NEI R01 support (four of these have submitted NEI R01s). Of the reminaing five participants, two are Co-Investigators an an active NEI R01 and three have submitted NEI R01s. Annually, NEI funding exceeds $3M million, not including internal UAB awards. Total annual extramural funding for vision-related research at UAB has grown to nearly $13 million. A major research focus of the participants is visual neuroscience, with 16 actively involved in anatomical, biochemical, physiological, or psychophysical studies of the retina and central visual pathways. Additionally, UAB vision research groups are focused on the study of glaucoma, AMD, myopia, keratoconus, dry eye and cataractogenesis. This application requests funds to continue to provide services and facilities to support the research activity of the participants through four professionally staffed cores. These cores provide state-of-the-art facilities and expertise in dedicated spaces designed specifically for each purpose. The Instrumentation Core is staffed by an electronics engineer who designs and builds complex novel electronic apparati and an expert machinist/tool and die maker who designs and fabricates unique mechanical devices. Both also repair and maintain current instruments greatly reducing repair costs. The Research Programming & Computational Analysis Core provides access to high-end analytical tools and is staffed by an experienced programmer/analyst with an MS in computer sciences who offers custom software development and software/hardware interfacing, and by a part-time experienced biostatistician who will assist in experimental design and statistical analysis. The Molecular & Cellular Analysis Core is staffed by an MD/PhD trained scientist who provides expertise for study design, training and access to major instrumentation for DNA, RNA and protein studies and morphologic analysis of tissues and cells. The new Ocular Phenotyping Core will be part-time staffed by a PhD who has several years of expertise in the use of all instrumentation for analysis of the structure and function of small animal models of human ocular disease. Since 1979, more than $17M has been provided in institutional support of vision research to date and more than $800,000 is committed over the next 5 years of requested NIH support. UAB vision science is in an exciting growth phase that is focused on the use of advanced technology and the recruitment of the best scientists to study and devise treatments for ocular disorders. The continuation of the P30 core grant for vision research is an essential element at the core of new discovery in vision science at UAB.

UAB 视觉科学研究中心 - 总体核心 7. 项目总结/摘要 1979 年，UAB 首次获得 NEI 核心资助。在接下来的 35 年里，该机构继续 对增长的承诺导致了视觉研究的显着扩展。目前参与人数已增加 从两个部门的13个增加到五个部门的23个，并且数量也随之增加 外部资金。 11 名核心参与者目前拥有 14 项合格补助金，另外 7 名拥有新的 NEI 调查员身份并正在寻求 NEI R01 支持（其中四家已提交 NEI R01）。的 剩下五名参与者，其中两名是联合研究者，一名活跃的 NEI R01，三名已提交 NEI R01。每年，NEI 的资助超过 300 万美元，其中不包括 UAB 内部奖励。每年校外总计 UAB 视觉相关研究的资金已增至近 1300 万美元。该研究的一个主要研究重点 参与者是视觉神经科学领域，其中 16 名积极参与解剖学、生物化学、生理学或 视网膜和中央视觉通路的心理物理学研究。此外，UAB 视觉研究小组 专注于青光眼、AMD、近视、圆锥角膜、干眼症和白内障发生的研究。这个应用程序 请求资金继续提供服务和设施以支持参与者的研究活动 通过四名专业人员组成的核心。这些核心提供最先进的设施和专业知识 专门为每种目的设计的专用空间。仪器核心由 设计和建造复杂新颖电子设备的电子工程师和专业机械师/工具 设计和制造独特机械设备的模具制造商。两者还修复和维护电流 大大降低仪器的维修成本。研究编程和计算分析核心 提供对高端分析工具的访问，并由经验丰富的程序员/分析师（拥有 MS）组成 计算机科学领域的专家，提供定制软件开发和软件/硬件接口，并由 兼职经验丰富的生物统计学家将协助实验设计和统计分析。这 分子和细胞分析核心由一位接受过医学博士/博士学位的科学家组成，他们为以下领域提供专业知识： 研究设计、培训以及使用用于 DNA、RNA 和蛋白质研究以及形态学的主要仪器 组织和细胞分析。新的眼表型核心将由一位拥有丰富经验的博士担任兼职人员 在使用所有仪器分析小型物体的结构和功能方面拥有多年的专业知识 人类眼病的动物模型。自 1979 年以来，已向机构提供了超过 1700 万美元的资金 迄今为止对视觉研究的支持，并在未来 5 年内承诺提供超过 800,000 美元 美国国立卫生研究院的支持。 UAB 视觉科学正处于一个令人兴奋的增长阶段，重点是使用先进的技术 技术并招募最优秀的科学家来研究和设计眼部疾病的治疗方法。这 继续为视觉研究提供 P30 核心拨款是新发现的核心要素 UAB 的视觉科学。