UAB Vision Science Research Center

UAB视觉科学研究中心-整体核心 7.项目摘要/摘要 1979年，NEI核心奖助金首次授予UAB。在接下来的35年里，该机构继续 对增长的承诺导致了视觉研究的显着扩张。参与者现在增加了 从两个部门的13个增加到5个部门的23个，并随之增加了 校外资金。其中11名核心参与者目前拥有14项符合资格的助学金，另有7名拥有NEI New 调查员身份并正在寻求NEI R01的支持(其中四个已提交了NEI R01)。中的 提醒五名参与者，两名联合调查员和一名现役NEI R01，三名已提交NEI R01S。每年，NEI的资金超过300万美元，这还不包括UAB的内部奖励。年度外墙总数 UAB为视觉相关研究提供的资金已增长到近1300万美元。的一个主要研究重点是 参与者是视觉神经科学，其中16人积极参与解剖学、生化、生理学或 视网膜和中央视觉通路的心理物理学研究。此外，UAB视力研究小组还 专注于青光眼、AMD、近视、圆锥角膜、干眼和白内障的研究。此应用程序 请提供资金，继续提供服务和设施，支持参与者的研究活动 通过四个专业人员配备的核心。这些核心提供最先进的设施和专业知识 专门为每种用途设计的专用空间。仪器核心的工作人员是 设计和制造复杂的新型电子设备的电子工程师和专业的机械师/工具 和模具制造商，设计和制造独特的机械设备。两者也都修复和维护电流 大大降低了仪器的维修成本。研究编程与计算分析的核心 提供对高端分析工具的访问，并配备有经验的程序员/分析师和MS 在提供定制软件开发和软件/硬件接口的计算机科学领域，并由 兼职的有经验的生物统计师，将协助实验设计和统计分析。这个 分子和细胞分析核心的工作人员是一名受过医学/博士培训的科学家，他为 研究设计、培训和使用DNA、RNA和蛋白质研究以及形态研究的主要仪器 组织和细胞的分析。新的眼部表型识别核心将由一名具有 在使用所有仪器进行小型结构和功能分析方面有数年的专业知识 人类眼病的动物模型。自1979年以来，已向机构提供了1700多万美元 到目前为止对视觉研究的支持，并承诺在未来5年内提供超过800,000美元的资金 国家卫生研究院的支持。UAB视觉科学正处于一个令人兴奋的增长阶段，专注于使用先进的 技术和招募最好的科学家来研究和设计治疗眼病的方法。这个 继续为视力研究提供P30核心补助金是#年新发现的核心要素 加州大学伯克利分校视觉科学。

UAB Vision Science Research Center - Overall Core 7. Project Summary/Abstract In 1979, an NEI Core grant was first awarded to UAB. Over the next 35 years, the institution's continued commitment to growth resulted in a remarkable expansion in vision research. Participants have now increased from 13 in two departments to 23 in five departments, and there has been a concomitant increase in extramural funding. Eleven of the Core participants currently hold 14 eligble grants, another 7 have NEI new investigator status and are seeking NEI R01 support (four of these have submitted NEI R01s). Of the reminaing five participants, two are Co-Investigators an an active NEI R01 and three have submitted NEI R01s. Annually, NEI funding exceeds $3M million, not including internal UAB awards. Total annual extramural funding for vision-related research at UAB has grown to nearly $13 million. A major research focus of the participants is visual neuroscience, with 16 actively involved in anatomical, biochemical, physiological, or psychophysical studies of the retina and central visual pathways. Additionally, UAB vision research groups are focused on the study of glaucoma, AMD, myopia, keratoconus, dry eye and cataractogenesis. This application requests funds to continue to provide services and facilities to support the research activity of the participants through four professionally staffed cores. These cores provide state-of-the-art facilities and expertise in dedicated spaces designed specifically for each purpose. The Instrumentation Core is staffed by an electronics engineer who designs and builds complex novel electronic apparati and an expert machinist/tool and die maker who designs and fabricates unique mechanical devices. Both also repair and maintain current instruments greatly reducing repair costs. The Research Programming & Computational Analysis Core provides access to high-end analytical tools and is staffed by an experienced programmer/analyst with an MS in computer sciences who offers custom software development and software/hardware interfacing, and by a part-time experienced biostatistician who will assist in experimental design and statistical analysis. The Molecular & Cellular Analysis Core is staffed by an MD/PhD trained scientist who provides expertise for study design, training and access to major instrumentation for DNA, RNA and protein studies and morphologic analysis of tissues and cells. The new Ocular Phenotyping Core will be part-time staffed by a PhD who has several years of expertise in the use of all instrumentation for analysis of the structure and function of small animal models of human ocular disease. Since 1979, more than $17M has been provided in institutional support of vision research to date and more than $800,000 is committed over the next 5 years of requested NIH support. UAB vision science is in an exciting growth phase that is focused on the use of advanced technology and the recruitment of the best scientists to study and devise treatments for ocular disorders. The continuation of the P30 core grant for vision research is an essential element at the core of new discovery in vision science at UAB.