HSPH-NIEHS Center for Environmental Health

描述(由申请人提供) 主题从哈佛-NIEHS环境健康中心的独特和决定性的力量开始，研究人员对环境暴露及其对健康的影响进行了无与伦比的人口和患者研究组合。这些对人类受试者的真实环境暴露的研究确保了中心的研究可以很容易地转化为公共卫生政策和临床实践。这些以人群为基础的调查与机械的实验室研究相结合，阐明了环境暴露导致健康影响的途径。该中心使这一合作伙伴关系成为富有成效的“双向道路”：来自种群的数据为动物和细胞培养模型中的路径研究提供信息并指导研究。反过来，来自途径研究的证据被用来改进或发展关于暴露和健康影响的新的人口研究。他们的“人口到路径”研究既提供了对人类人口风险的估计，也增加了对环境健康影响的机制路径的理解。对人口和路径的调查反过来又为公共卫生政策和临床实践提供信息。 为了促进互动，该中心围绕代表主要交叉环境健康暴露的三个研究核心进行组织：金属、有机化学品和颗粒物。每个研究核心都有生产力的记录、持续增长的潜力，以及整合和催化未来领导能力的能力。每个研究核心都是多学科的，并部署了我们所有的智力资源。这些研究核心通过研讨会和专题讨论会、特邀演讲者、工作组和试点项目，在促进一体化和协作方面卓有成效。三个研究核心中的每一个都以毒理学、基本机制、体外模型、动物模型、基因-环境相互作用、流行病学、风险分析、风险沟通为特色，并与社区推广和教育核心相联系。每一项都包括暴露评估以及在动物模型和人类群体中的健康结果。此外，每一项都代表着一个有相当大的活动和成就的领域，以及一份令人信服的尚未解决的问题清单。通过使用中心机制来加强整合，每个研究核心不仅由来自不同学科的个人组成，而且还由来自哈佛大学和邻近机构的一系列学术项目和部门的个人组成。 社区外联和教育核心(COEC)为中心内开展的研究和综合健康科学提供社区背景，支持中心将其研究转化为公共卫生政策和临床实践的目标，并作为社区和利益攸关方在确定研究优先事项和机会方面与中心互动并向其提供指导的渠道。

DESCRIPTION (provided by applicant) The theme begins with a unique and defining strength of the Harvard-NIEHS Center for Environmental Health, the investigators' unmatched portfolio of population and patient studies of environmental exposures and their health effects. These studies of the real-world environmental exposures of human subjects ensure that Center research readily translates into public health policy and clinical practice. These population-based investigations combine with mechanistic laboratory studies to illuminate the pathways by which environmental exposures cause health effects. The Center makes this partnership a productive "two-way street": Data from populations inform and guide studies of pathways in animal and cell culture models. In turn, the evidence from pathway studies is used to improve or develop new population studies of exposures and health effects. Together their "Populations to Pathways" research provides both estimates of human population risk as well as adding to the understanding of mechanistic pathways of environmental health effects. The investigations of populations and pathways in turn inform public health policy and clinical practice. To facilitate interactions the Center is organized around three Research Cores representing major cross-cutting environmental health exposures: Metals, Organic Chemicals, and Particulates. Each of the Research Cores has track record of productivity, potential for continued growth, and the ability to integrate and catalyze leadership in the future. Each Research Core is multidisciplinary and deploys the full range of our intellectual resources. These Research Cores have been highly effective in promoting integration and collaborations through seminars and symposium, invited speakers, working groups, and pilot projects. Each of the three Research Cores features toxicology, basic mechanisms, in vitro models, animal models, gene- environment interactions, epidemiology, risk analysis, risk communication and connects to the Community Outreach and Education Core. Each includes exposure assessment as well as health outcomes in both animal models and human populations. Moreover, each represents an area of considerable activity and accomplishment as well as a compelling list of unsolved concerns. By using the Center mechanism to increase integration, each Research Core is composed of individuals not only from a variety of disciplines, but also from a range of academic programs and departments throughout Harvard and at neighboring institutions. The Community Outreach and Education Core (COEC) provides a community context for the research and integrated health sciences occurring within the Center and supports the Center's goal to translate its research into public health policy and clinical practice, and serves as a conduit for the community and stakeholders to interact with and provide guidance to the Center in defining research priorities and opportunities.