HSPH-NIEHS Center for Environmental Health

HSPH-NIEHS 环境健康中心

• 批准号: 9259978
• 负责人: Douglas W Dockery
• 金额: $ 172.17万
• 依托单位: HARVARD SCHOOL OF PUBLIC HEALTH
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-04-01 至 2019-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9259978
• 关键词: Address; Animal Model; Animals; Area; Cell Culture Techniques; Clinical Research; Collaborations; Communication; Communities; Community Health Education; Community Outreach; Data; Discipline; Ensure; Environmental Exposure; Environmental Health; Epidemiology; Family; Future; Goals; Growth; Health; Health Policy; Health Sciences; Home environment; Human; Individual; Institution; Interdisciplinary Study; Investigation; Laboratory Study; Leadership; Metal exposure; Methods; Modeling; Modernization; National Institute of Environmental Health Sciences; Neighborhoods; Organic Chemicals; Outcome; Particulate; Pathway interactions; Patients; Pilot Projects; Population; Population Study; Productivity; Public Health; Public Policy; Research; Research Personnel; Research Priority; Resources; Risk; Technology; Toxicology; Training; Translating; Universities; academic program; clinical practice; gene environment interaction; human subject; improved; in vitro Model; laboratory facility; multidisciplinary; next generation; population based; public health relevance; symposium; tool; working group

DESCRIPTION (provided by applicant) The theme begins with a unique and defining strength of the Harvard-NIEHS Center for Environmental Health, the investigators' unmatched portfolio of population and patient studies of environmental exposures and their health effects. These studies of the real-world environmental exposures of human subjects ensure that Center research readily translates into public health policy and clinical practice. These population-based investigations combine with mechanistic laboratory studies to illuminate the pathways by which environmental exposures cause health effects. The Center makes this partnership a productive "two-way street": Data from populations inform and guide studies of pathways in animal and cell culture models. In turn, the evidence from pathway studies is used to improve or develop new population studies of exposures and health effects. Together their "Populations to Pathways" research provides both estimates of human population risk as well as adding to the understanding of mechanistic pathways of environmental health effects. The investigations of populations and pathways in turn inform public health policy and clinical practice. To facilitate interactions the Center is organized around three Research Cores representing major cross-cutting environmental health exposures: Metals, Organic Chemicals, and Particulates. Each of the Research Cores has track record of productivity, potential for continued growth, and the ability to integrate and catalyze leadership in the future. Each Research Core is multidisciplinary and deploys the full range of our intellectual resources. These Research Cores have been highly effective in promoting integration and collaborations through seminars and symposium, invited speakers, working groups, and pilot projects. Each of the three Research Cores features toxicology, basic mechanisms, in vitro models, animal models, gene- environment interactions, epidemiology, risk analysis, risk communication and connects to the Community Outreach and Education Core. Each includes exposure assessment as well as health outcomes in both animal models and human populations. Moreover, each represents an area of considerable activity and accomplishment as well as a compelling list of unsolved concerns. By using the Center mechanism to increase integration, each Research Core is composed of individuals not only from a variety of disciplines, but also from a range of academic programs and departments throughout Harvard and at neighboring institutions. The Community Outreach and Education Core (COEC) provides a community context for the research and integrated health sciences occurring within the Center and supports the Center's goal to translate its research into public health policy and clinical practice, and serves as a conduit for the community and stakeholders to interact with and provide guidance to the Center in defining research priorities and opportunities.

描述（由申请人提供） 该主题始于哈佛-NIEHS环境健康中心的独特而定义的力量，研究人员无与伦比的人口组合以及对环境暴露及其健康影响的患者研究。这些对人类受试者现实环境暴露的研究确保了中心研究很容易转化为公共卫生政策和临床实践。这些基于人群的研究与机械实验室研究相结合，以阐明环境暴露会导致健康影响的途径。该中心使该伙伴关系成为富有成效的“双向街道”：人群的数据为动物和细胞培养模型中的途径提供了信息和指导研究。 反过来，途径研究的证据被用来改善或发展有关暴露和健康影响的新人群研究。他们的“人口到途径”研究共同提供了人口风险的估计，也增加了对环境健康效应机械途径的理解。对人口和途径的调查又为公共卫生政策和临床实践提供了信息。 为了促进相互作用，该中心围绕三个研究核心组织，代表了主要的横切环境健康暴露：金属，有机化学物质和颗粒物。 每个研究核心都有生产力的记录，持续增长的潜力以及将来整合和催化领导能力的能力。每个研究核心都是多学科的，并部署了我们的全部智力资源。这些研究核心在通过研讨会和研讨会，邀请演讲者，工作组和试点项目来促进整合和合作方面非常有效。这三个研究核心中的每一个都有毒理学，基本机制，体外模型，动物模型，基因环境相互作用，流行病学，风险分析，风险交流以及与社区外展和教育核心的联系。 每个都包括暴露评估以及动物模型和人类种群中的健康状况。此外，每个都代表了一个相当大的活​​动和成就以及令人信服的未解决问题的清单。通过使用中心机制来增加整合，每个研究核心不仅由个体组成，不仅来自各种学科，而且还由整个哈佛大学和邻近机构的一系列学术计划和部门组成。 社区宣传和教育核心（COEC）为中心内发生的研究和综合健康科学提供了社区环境，并支持该中心将其研究转化为公共卫生政策和临床实践的目标，并为社区和利益相关者提供渠道，以与中心互动并为中心互动并提供指导，以确定研究优先级和机会。