American Indian - Alaska Native Clinical and Translational Research Center (AI-AN CTRC)

 描述（由申请人提供）：美国印第安人-阿拉斯加土著临床和转化研究中心（AI-AN CTRC）的目标是发展蒙大拿州和阿拉斯加州的能力，以解决这些州的土著社区在健康差异方面面临的独特问题。AN-AI-AN CTRC将通过研究服务核心和社区参与研究项目的资助，增加AK和MT的调查人员数量，培训，支持和指导，以解决MT和AK土著社区的健康差距。蒙大拿州立大学将成为该项目的所在机构，并将与Blackfeet社区学院（BCC），蒙大拿大学（UM），阿拉斯加大学费尔班克斯（UAF），阿拉斯加安克雷奇大学（UAA），安克雷奇阿拉斯加土著部落健康联盟（ANCTH）和安克雷奇中南部基金会（SCF）合作。BCC、ANCTH和SCF由部落社区拥有和管理。为了实现这些目标，AI-AN CTRC将：1.通过持续发展共享设施，智力资源，研究合作，重点工作组和培训机会，加强蒙大拿州和阿拉斯加州的临床和转化研究基础设施。MT和AK成立的研究者将开发5个研究核心，包括：社区参与和外展核心（CEOC），将指导研究者完成社区参与研究过程;专业发展核心（PDC），将培训和指导临床健康差异研究的研究者;试点项目计划核心（PPPC）将资助试点研究项目，以促进新的临床研究者开发可资助的项目;研究设计，流行病学和生物统计学核心（RDEBC）将提供各级所需的流行病学和统计方法方面的专业知识， 临床研究过程;以及跟踪和评估核心（TEC），它将不断监测中心及其组成部分的进展。2.增加数量，导师，并在蒙大拿州和阿拉斯加州的土著健康差异研究发展临床研究人员的职业生涯。这将通过发展新的临床研究人员的研究能力，发展尚未在土著健康领域工作的科学家的兴趣来建立这一领域的项目，发展土著健康研究中已建立的临床研究人员的能力，以形成包括基础科学研究人员在内的跨学科研究团队。3.扩大和支持可持续和文化上负责任的社区参与研究，这将减轻蒙大拿州和阿拉斯加州土著社区的健康差距。AI-AN CTRC将支持MT和AK调查人员与土著社区建立关系，建立社区的研究能力，并生成向NIH等资助机构提供赠款提案所需的初步数据。这将导致AK和MT的可持续方案，从而改善这些州土著社区的健康状况。

 DESCRIPTION (provided by applicant): The American Indian-Alaska Native Clinical and Translational Research Center (AI-AN CTRC) has the goal of developing the capacity of Montana and Alaska to address the unique problems these state's Native communities face in health disparities. AN-AI-AN CTRC will increase numbers of, train, support, and mentor investigators from AK and MT through research service cores and funding of community engagement research projects to address health disparities in MT's and AK's Native communities. Montana State University will be the home institution for this project and will partner with Blackfeet Community College (BCC), University of Montana (UM), University of Alaska Fairbanks (UAF), University of Alaska Anchorage (UAA), Alaska Native Tribal Health Consortium (ANCTH) of Anchorage, and Southcentral Foundation (SCF) of Anchorage. BCC, ANCTH, and SCF are owned and managed by tribal communities. To realize these goals, AI-AN CTRC will: 1. Strengthen Montana's and Alaska's clinical and translational research infrastructure through continued development of shared facilities, intellectual resources, research collaborations, focused working groups, and training opportunities. MT and AK established investigators will develop 5 research cores which include: the Community Engagement and Outreach Core (CEOC), which will guide investigators through the process of community engagement research; the Professional Development Core (PDC), which will train and mentor investigators in clinical health disparities research; the Pilot Project Program Core (PPPC) will fund pilot research projects to facilitate the development of fundable programs by new clinical investigators; the Research Design, Epidemiology and Biostatistics Core (RDEBC), will provide expertise in epidemiological and statistical methodologies needed at all levels of the clinical research process; and the Tracking and Evaluation Core (TEC) which will constantly monitor the progress of the center and its components. 2. Increase numbers, mentor, and develop the careers of clinical investigators in Native health disparities research in Montana and Alaska. This will be accomplished by developing the research capacity of new clinical investigators, developing interest of scientists not already working in Native health to build programs in this area, developing the ability of established clinical investigators in Native healt research to form interdisciplinary research teams including basic science researchers. 3. Expand and support sustainable and culturally responsible community engagement research that will mitigate health disparities in Montana's and Alaska's Native communities. The AI-AN CTRC will support MT and AK investigators to establish relationships with Native communities, build research capacity in the communities, and generate preliminary data required for grant proposals to funding agencies such as NIH. This will result in sustainable programs in AK and MT that will result in improved health of these state's Native communities.