Investigating Obesity and Chronic Disease-Related Risk Factors of Alaska Natives

阿拉斯加原住民健康研究中心（CANHR）成立于2001年，由COBRE I支持，因其研究质量而获得全国认可，以减少阿拉斯加原住民（AN）的疾病和促进健康，并以社区为基础进行研究（CBPR）与少数民族人口。AN人一直参与CANHR研究的各个阶段，包括制定CANHR目前关于肥胖和代谢疾病的研究议程。这一长达十年的社区伙伴关系的演变和巩固已将这一研究议程扩大到旨在预防和治疗肥胖和代谢疾病、青年自杀和药物滥用的干预研究。CANHR的资金从2001年的一笔NIH赠款增加到2010年的近500万美元。在NIH建设赠款的支持下，我们正在阿拉斯加州建造前两个临床研究实验室，同时将我们的净空间增加了5，000多平方米。英尺阿拉斯加大学费尔班克斯领导层已经增加了对CANHR的实质性承诺，通过总统教授计划，通过新的教师招聘和国家认可的高级研究人员的咨询，进一步增强了我们的研究专业知识。我们的出版率继续增加，在过去四年中超过100份出版物。拟议的COBRE第三阶段过渡中心的目标是巩固这些成就，重点是将CANHR转变为一个自我支持，可持续，国家认可的研究中心，专注于AN健康和CBPR。为此，我们建议：（1）加强核心资源的基础设施，以支持研究和社区参与;（2）扩大指导和培训机会，以培养下一代的AN健康研究人员;（3）制定创新的试点项目计划（具体专业知识的外部伙伴关系），以促进与研究密集型机构的科学领导人的合作研究，根据我们的经验，将p9 sitatively影响我们的校外资金的成功;（4）继续总统的教授计划，以扩大知识资本和国家承认CANHR;（5）包括一个全面的商业计划，以确保收入，以维持CANHR核心。

The Center for Alaska Native Health Research (CANHR), established in 2001 with COBRE I support, has become nationally recognized for both the quality of its research to reduce disease and promote health among Alaska Native (AN) people and for Community-Based Participatory Research (CBPR) with minority populations. AN people have been engaged in all phases of CANHR research, including setting CANHR's current research agenda on obesity and metabolic disease. The evolution and solidification of this decade-long community partnership has expanded this research agenda into intervention research aimed at prevention and treatment of obesity and metabolic disease, youth suicide, and substance abuse. CANHR funding has increased from one NIH grant in 2001, to nearly $5M in 2010. With support from an NIH construction grant, we are building the first two clinical research laboratories in the state of Alaska, while increasing our net space by over 5,000 sq. ft. The University of Alaska Fairbanks leadership has increased its already substantial commitment to CANHR, further augmenting our research expertise with new faculty hires and consultation from nationally recognized senior researchers through the President's Professors program. Our publication rate continues to increase, surpassing 100 publications in the past four years. The goal of the proposed COBRE Phase III Transitional Center is to solidify these achievements with a focus on transitioning CANHR into a self-supporting, sustainable, nationally recognized research center focused on AN health and CBPR. We propose to do this by: (1) strengthening the infrastructure of core resources to support research and community engagement; (2) expanding mentoring and training opportunities to develop the next generation of AN health researchers; (3) developing an innovative Pilot Project program (External Partnerships for Specific Expertise), to foster collaborative research with scientific leaders at research-intensive institutions that, in our experience, will p9sitively impact our extramural funding success; (4) continuing the President's Professors Program to expand intellectual capital and national recognition of CANHR; and (5) including a comprehensive business plan to ensure income to sustain CANHR cores.