Pilot Project Core

路易斯维尔大学酒精研究中心(ULARC)是为了充当 区域/国家资源，以研究酒精所致器官损伤的机制并开发 预防/治疗这种器官损伤的新药物/干预措施，这两种药物都是重要的未得到满足的 研究需求。该中心的主题在酒精中心中是独一无二的：营养在 酒精诱导的器官损伤的发展/进展和潜在的预防/治疗。这个 Pilots Core将通过资助致力于这一研究主题的新项目来为这一计划做出贡献。我们会 为此，要支持青年调查员，并招募老牌调查员，他们建议 代表其研究方向改变的项目。Pilot Core的目标是提供支持 对酒精引起的器官损伤进行有前景的临床和翻译研究。这种支持将是有针对性的 主要针对新的研究人员，那些新进入酒精临床和翻译研究的人，以及酒精 临床/转化型研究人员跨部门和机构协作。我们将提供一个 鼓励开展试点项目的环境，为酒精研究人员提供 执行符合以下条件的创新临床/转化性研究所需的信息、资源和指导 21世纪科学的要求。此外，我们还将改善现有和 为大学及其附属机构的试点项目提供新的机会和资源。这个 ULARC将为寻求进行酒精研究的调查人员提供一个明确的切入点。我们将到达我们的 通过以下具体目标实现目标：1)要求潜在的试点项目与 ULARC的总主题：营养和酒精引起的器官损伤；2)协调评估 符合ULARC试点方案标准和目标的新试点项目申请； 3)协助试点项目获得者获得校外资金。这一试点计划将建立在UofL的 在确定有希望的试点项目以提供支持方面已经有了突出的记录。成立法律援助法委员会和 试点计划将大大增加目前可用的试点计划资金，并极大地 在UofL推动新的酒精研究。

The University of Louisville Alcohol Research Center (ULARC) was created to serve as a regional/national resource to investigate mechanisms of alcohol induced organ injury and to develop new agents/interventions to prevent/treat this organ injury, both of which represent important unmet research needs. The theme of the center is unique among alcohol centers: the role of nutrition in the development/progression and potential prevention/treatment of alcohol-induced organ injury. The Pilots Core will contribute to this program by funding new projects dedicated to this theme of research. We will do this by supporting Young Investigators, as well as recruiting Established Investigators, who propose projects that represent a change in direction for their research. The goal of the Pilot Core is to provide support for promising clinical and translational research in alcohol-induced organ injury. This support will be targeted mainly at new investigators, those newly entering alcohol clinical and translational research, and alcohol clinical/translational investigators collaborating across departments and institutions. We will provide an environment that encourages development of pilot projects by providing alcohol researchers with the information, resources and mentoring needed to perform innovative clinical/translational research that meets the demands of 21st century science. In addition, we will improve the flow of information about existing and new opportunities and resources for pilot projects among University components and our affiliates. The ULARC will provide a clear entry point for investigators seeking to conduct alcohol research. We will reach our goal through the following Specific Aims: 1) To request potential pilot projects that coordinate with the overall theme of the ULARC: Nutrition and Alcohol-Induced Organ Injury; 2) To coordinate evaluation of new pilot project applications which conform to the criteria and goals of the ULARC pilot program; 3) To assist pilot project recipients to achieve extramural funding. This Pilot Program will build on UofL's already outstanding record of identifying promising pilot projects for support. Establishment of the ULARC and the Pilot Program will provide a significant boost to the currently available pilot program funding and greatly stimulate novel alcohol research at UofL.