2/2 The GUIDE Pilot Research Project Core

2/2 GUIDE 试点研究项目核心

• 批准号: 9152327
• 负责人: Catherine Hanson Balthazar
• 金额: $ 6.28万
• 依托单位: GOVERNORS STATE UNIVERSITY
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/9152327
• 关键词: Address; African American; Appointments and Schedules; Assessment tool; Breast; Breast Cancer Detection; Breast Cancer Prevention; Caring; Chemoprevention; Chicago; Color; Communities; DNA; Diagnosis; Early Diagnosis; Educational Intervention; Educational Materials; Evaluation; Family; Feasibility Studies; Federally Qualified Health Center; Feedback; Genetic Counseling; Genetic Predisposition to Disease; Genetic Risk; Guidelines; Illinois; Incidence; International Union Against Cancer; Intervention; Interview; Learning; Magnetic Resonance Imaging; Mammography; Minority; Modeling; Operative Surgical Procedures; Other Genetics; Patients; Pilot Projects; Practice Guidelines; Predisposition; Primary Care Physician; Primary Health Care; Provider; Recommendation; Recording of previous events; Reporting; Research Personnel; Research Project Grants; Research Training; Risk; Risk Assessment; Risk Factors; Risk Reduction; Role; Side; Software Tools; Technology; Testing; Time; Transportation; Universities; Visit; Woman; Work; anticancer research; base; behavior prediction; cancer genetics; cancer risk; design; follow-up; genetic counselor; handheld mobile device; improved; malignant breast neoplasm; meetings; mortality; mortality disparity; multidisciplinary; population based; routine care; screening; shared decision making; software development; tailored messaging; therapy design; tool; training project; uptake

PROJECT SUMMARY: Advances in cancer genetics and risk assessment make it possible to identify women with increased risk for breast cancer (BC) due to genetic and other risk factors. An array of interventions is available to reduce BC incidence and improve early detection among asymptomatic women. National practice guidelines now recommend individualized risk assessments (IRA) to determine BC risk status as part of routine primary healthcare. Genetic counseling for in-depth evaluation and to determine the role of predictive DNA testing is a critical step in developing an individualized plan for risk reduction. Implementing population-based BC risk assessment in Federally Qualified Health Centers (FQHC) to identify women who would benefit from genetic counseling provides an opportunity to impact the large BC mortality disparity observed between African-American (AA) and white women.This pilot research project builds on previous work examining the feasibility of implementing population-based IRA in FQHCs as part of routine care. More than 1200 minority women completed the assessment and 10% met criteria for referral to a genetic counselor. Half of these women were referred for a free genetic counseling session, but only 15% of eligible women scheduled an appointment. Follow-up interviews revealed a strong desire for information among AA women identified with increased BC risk, providing an opportunity to deliver culturally tailored messaging in the form of an educational intervention designed to increase uptake of genetic counseling. We propose: Aim 1. Develop a team of investigators from Governors State Univtoersity and the University of Illinois to create a technology-based, culturally informed educational intervention for AA women with increased BC risk. Aim 2. Create a culturally tailored educational intervention delivered on a mobile device platform designed to improve uptake of genetic counseling among underserved AA women with increased BC. Aim 3. Conduct a pilot study to demonstrate the feasibility of incorporating the educational intervention with IRA in an FQHC on the south side of Chicago.

项目概要： 癌症遗传学和风险评估的进展使得有可能识别出患有癌症的女性。 由于遗传和其他风险因素，乳腺癌（BC）的风险。可采取一系列干预措施 减少BC发病率，提高无症状妇女的早期发现率。国家实践 指南现在建议进行个性化风险评估（伊拉），以确定BC风险状态， 常规的初级卫生保健。遗传咨询，进行深入评估并确定 预测性DNA检测是制定个性化降低风险计划的关键一步。 在联邦合格卫生中心（BHC）实施基于人群的BC风险评估， 确定哪些妇女将受益于遗传咨询提供了一个机会，影响大 在非洲裔美国人（AA）和白色妇女之间观察到BC死亡率的差异。 该项目建立在以前的工作，审查实施人口为基础的伊拉的可行性， 作为常规护理的一部分。1200多名少数民族妇女完成了评估，10%的妇女在评估中获得了平等机会。 符合转介遗传咨询师的标准这些妇女中有一半被转介到一个免费的遗传 咨询会议，但只有15%的合格妇女安排了预约。后续采访 显示了AA妇女对BC风险增加的信息的强烈愿望， 以教育干预的形式提供适合文化的信息的机会 旨在提高遗传咨询的接受率。我们建议： 目标1。从州长州立大学和伊利诺伊大学组建一个调查小组 为AA女性制定基于技术、文化知情的教育干预措施， BC风险增加。 目标2.创建在移动终端平台上提供的文化定制教育干预 旨在提高遗传咨询服务不足的AA妇女与BC增加。 目标3。开展试点研究，以证明将教育 在芝加哥南部的一个反政府武装中心与伊拉进行了干预。