Leveraging record linkage for single-indication medications to boost recruitment in Psychiatric and Pharmaco- Genetics

利用单适应症药物的记录关联来促进精神病学和药物遗传学领域的招募

• 批准号: nhmrc : GNT1138514
• 负责人: Prof Ian Hickie
• 金额: $ 184.06万
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2018
• 资助国家: 澳大利亚
• 起止时间: 2018-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/leveraging-linkage-single-pharmaco-genetics/1348153
• 关键词: Leveraging; record; linkage; single; indication

Genome-wide association studies (GWAS) have shown that psychiatric disorders are highly polygenic and that increasing the power of these analyses by increasing the number of participants does lead to the identification of new treatment targets and biomarkers. We seek funding to greatly boost the power of GWAS for Schizophrenia and Bipolar Disorder by using prescription records to recruit individuals who have been prescribed medications that are only used to treat these conditions.

全基因组关联研究（GWAS）表明，精神疾病具有高度多基因性，通过增加参与者数量来增强这些分析的能力确实可以确定新的治疗靶点和生物标志物。我们寻求资金，通过使用处方记录来招募仅用于治疗这些疾病的处方药物的个人，从而大大增强 GWAS 对精神分裂症和双相情感障碍的功效。