2016 Drug Carriers in Medicine & Biology Gordon Research Conferences and Gordon Research Seminar

 描述（由申请人提供）：小分子、蛋白质和生物药物、核酸和其他分子疗法的递送依赖于药物的可及性，这高度依赖于管理药物溶解度、稳定性、生物分布和药代动力学的能力。药物载体的医学和生物学戈登研究会议（GRC），及其伴随的戈登研究研讨会（GRS）提供了一个关键的平台，讨论和传播的关键发展的药物输送系统的设计，以满足这一领域的许多独特的挑战。解决这些问题需要一种跨学科的方法，涉及基础生物学和生理学，化学和物理学，为设计提供信息，以及工程和临床观点。GRC提供了一个独特的环境，成功地将这些团体聚集在一起，讨论和辩论有关交付的基本问题，并分享该领域的新创新。本GRC/GRS的具体目的是：1）提供一个论坛，讨论输送和生理学理解的主要障碍，以告知载体设计。2)促进在智力和文化多样性，多学科的环境中讨论传递系统，并从工程，生理，监管和翻译的角度输入。3)为了使新的创新和前沿研究在药物输送领域的演示和讨论，4）为年轻的教师和该领域的其他早期研究人员创造机会，介绍他们的工作，并建立关键的关系和伙伴关系，以促进专业发展。2016年GRC的主题和副标题是“了解生理障碍以告知设计”。传递的关键障碍是会议的焦点，从内皮和上皮屏障到细胞外基质和细胞内运输。研讨会的重点领域包括癌症，疫苗，传染病，纳米医学方法，以及将药物输送到大脑，肺，肠道和其他器官。在GRC之前发生的GRS使研究生和博士后能够从自己的角度研究该领域并解决重要问题，作为正在思考该领域未来的早期研究者。演讲者将从广泛的机构和学科的研究学员中选出。2016年GRS的主题是“将基础科学转化为临床成功：弥合体外和体内成功药物载体之间的差距”，将提供一个讨论论坛，将正在进行的实验室研究和可能最终决定转化成功的各种问题联系起来。GRS还将有一位全体发言人，可以就这个问题提供深入的观点，以及从该领域的领导者中选出的讨论领导者，他们可以在讨论期间提供背景和观点。要求提供资金，使学生，博士后研究人员和早期职业教师，以及不同的演讲者和讨论领导人，包括代表性不足的少数民族和妇女的出席。

 DESCRIPTION (provided by applicant): The delivery of small molecules, proteins and biologic drugs, nucleic acids and other molecular therapies relies on the accessibility of the drug, which is highly dependent on the ability to manage solubility, stability, biodistribution and pharmacokinetics of the drug. The Drug Carriers for Medicine and Biology Gordon Research Conference (GRC), and its accompanying Gordon Research Seminar (GRS) provide a key platform for discussion and dissemination of critical developments in the design of drug delivery systems to meet the many unique challenges of this field. Addressing these issues requires an interdisciplinary approach that engages basic biology and physiology, chemistry and physics that inform design, as well as engineering and clinical perspectives. The GRC provides a unique environment that successfully brings these groups together to discuss and debate fundamental questions about delivery, and to share new innovations in the field. The specific aims of this GRC/GRS are to 1) To provide a forum for discussion of the key barriers to delivery and physiological understanding to inform carrier design. 2) Facilitate discussion of delivery systems in an intellectually and culturally diverse, multidisciplinary environment, with input from engineering, physiological, regulatory and translational perspectives. 3) To enable presentation and discussion of new innovations and cutting edge research in the drug delivery field and 4) Create opportunities for young faculty and other early investigators in the field to present their work and to build critical relationships and partnerships for professional advancement. The theme and subtitle for the 2016 GRC is "Understanding physiological barriers to inform design". The key barriers to delivery are the focus of sessions, ranging from endothelial and epithelial barriers to extracellular matrix and intracellular trafficking. Areas of focus in the seminar inclue cancer, vaccines, infectious disease, nanomedicine approaches, and delivery of drugs to the brain, lung, gut and other organs. The GRS that takes place prior to the GRC enables graduate students and postdoctoral associates to examine the field and address important questions from their own perspectives as early investigators who are thinking toward the future of the field. Speakers will be selected from among research trainees across a broad range of institutions and disciplines. The 2016 GRS theme, which is "Translating Basic Science to Clinical Success: Bridging the Gap Between Successful Drug Carriers in vitro and in vivo", will provide a forum for discussion that connects ongoing laboratory research and the kinds of issues that might ultimately determine translational success. The GRS will also feature a plenary speaker that can provide deep perspective on this question, and discussion leaders chosen from among leaders in the field who can provide background and perspective during the discussions. Funding is requested to enable attendance of students, postdoctoral investigators, and early career faculty, as well as a diverse group of speakers and discussion leaders, including underrepresented minorities and women.