2016 Drug Carriers in Medicine & Biology Gordon Research Conferences and Gordon Research Seminar

 描述(申请人提供)：小分子、蛋白质和生物药物、核酸和其他分子疗法的提供取决于药物的可及性，而药物的可及性高度依赖于管理药物的溶解度、稳定性、生物分布和药代动力学的能力。药物载体用于医学和生物的戈登研究会议(GRC)及其伴随的戈登研究研讨会(GRS)为讨论和传播药物输送系统设计方面的关键发展提供了一个关键平台，以应对该领域的许多独特挑战。解决这些问题需要一种跨学科的方法，涉及基础生物学和生理学、化学和物理学，为设计提供信息，以及工程和临床观点。GRC提供了一个独特的环境，成功地将这些小组聚集在一起，讨论和辩论关于交付的基本问题，并分享该领域的新创新。GRC/GRS的具体目标是：1)提供一个讨论传递的关键障碍和生理理解的论坛，为载体设计提供信息。2)促进在智力和文化多元化的多学科环境中讨论交付系统，并从工程、生理、监管和翻译角度提供意见。3)能够介绍和讨论药物输送领域的新创新和尖端研究；4)为该领域的年轻教员和其他早期研究人员创造机会，介绍他们的工作，并建立关键的关系和伙伴关系，促进专业发展。2016年GRC的主题和副标题是“了解生理障碍，为设计提供信息”。传递的关键障碍是会议的重点，从内皮和上皮性障碍到细胞外基质和细胞内运输。研讨会的重点领域包括癌症、疫苗、传染病、纳米医学方法以及将药物输送到大脑、肺、肠道和其他器官。在GRC之前进行的GRS使研究生和博士后助理能够从他们自己的角度审视该领域，并从他们自己的角度解决重要问题，他们是思考该领域未来的早期研究者。演讲者将从广泛的机构和学科的研究学员中挑选出来。2016年GRS的主题是“将基础科学转化为临床成功：在体外和体内弥合成功的药物载体之间的差距”，将提供一个讨论论坛，将正在进行的实验室研究与可能最终决定翻译成功的问题类型联系起来。GRS还将有一名全体演讲者就这一问题提供深入的观点，并从该领域的领导人中挑选能够在讨论期间提供背景和观点的讨论领导人。要求提供资金，以使学生、博士后研究人员和职业生涯早期教师以及包括代表人数不足的少数群体和妇女在内的不同演讲者和讨论领袖出席会议。

 DESCRIPTION (provided by applicant): The delivery of small molecules, proteins and biologic drugs, nucleic acids and other molecular therapies relies on the accessibility of the drug, which is highly dependent on the ability to manage solubility, stability, biodistribution and pharmacokinetics of the drug. The Drug Carriers for Medicine and Biology Gordon Research Conference (GRC), and its accompanying Gordon Research Seminar (GRS) provide a key platform for discussion and dissemination of critical developments in the design of drug delivery systems to meet the many unique challenges of this field. Addressing these issues requires an interdisciplinary approach that engages basic biology and physiology, chemistry and physics that inform design, as well as engineering and clinical perspectives. The GRC provides a unique environment that successfully brings these groups together to discuss and debate fundamental questions about delivery, and to share new innovations in the field. The specific aims of this GRC/GRS are to 1) To provide a forum for discussion of the key barriers to delivery and physiological understanding to inform carrier design. 2) Facilitate discussion of delivery systems in an intellectually and culturally diverse, multidisciplinary environment, with input from engineering, physiological, regulatory and translational perspectives. 3) To enable presentation and discussion of new innovations and cutting edge research in the drug delivery field and 4) Create opportunities for young faculty and other early investigators in the field to present their work and to build critical relationships and partnerships for professional advancement. The theme and subtitle for the 2016 GRC is "Understanding physiological barriers to inform design". The key barriers to delivery are the focus of sessions, ranging from endothelial and epithelial barriers to extracellular matrix and intracellular trafficking. Areas of focus in the seminar inclue cancer, vaccines, infectious disease, nanomedicine approaches, and delivery of drugs to the brain, lung, gut and other organs. The GRS that takes place prior to the GRC enables graduate students and postdoctoral associates to examine the field and address important questions from their own perspectives as early investigators who are thinking toward the future of the field. Speakers will be selected from among research trainees across a broad range of institutions and disciplines. The 2016 GRS theme, which is "Translating Basic Science to Clinical Success: Bridging the Gap Between Successful Drug Carriers in vitro and in vivo", will provide a forum for discussion that connects ongoing laboratory research and the kinds of issues that might ultimately determine translational success. The GRS will also feature a plenary speaker that can provide deep perspective on this question, and discussion leaders chosen from among leaders in the field who can provide background and perspective during the discussions. Funding is requested to enable attendance of students, postdoctoral investigators, and early career faculty, as well as a diverse group of speakers and discussion leaders, including underrepresented minorities and women.