Antimicrobial catheters with cell and tissue compatibility

聚合物勘探集团有限责任公司PA-14-071摘要 项目名称：具有细胞和组织相容性的抗菌导管 摘要 导尿管相关性尿路感染(CAUTIs)常见于随后的 抗生素的使用有助于细菌耐药性的增强。抛在身后 包括释放银和抗菌剂在内的常规方法，正在开发一种新的聚乙二醇酯 生产可杀死细菌但与人体细胞相容的导管的方法。这个 这种新的涂层方法的承诺不是基于任何单一的特征，而是基于 前所未有的功能组合。其中包括经济实惠的“明智选择” 化学和加工。拟议的第二阶段研究基于一个很有前途的范例- 结合体外和体内评估的破碎性方法，旨在评估可行性 和FDA的要求。一个强大的跨学科团队致力于“自下而上”的生物材料 在“自上而下”的需求面前满足强烈需求的工程 经济上前所未有的能力。事实上，聚乙二醇-有限责任公司的研究承诺有一个主要的 不仅对改善患者的预后产生影响，而且在减少 迅速上涨的医疗费用。 关键词：导尿管；大衣；细胞相容性；抗菌；

Polymer Exploration Group LLC PA-14-071 Abstract Project Title: Antimicrobial catheters with cell and tissue compatibility Abstract Catheter associated urinary tract infections (CAUTIs) are often encountered with subsequent antibiotic administration contributing to buildup of bacterial resistance. Leaving behind customary methods including release of silver and antimicrobials, PEG LLC is developing a new approach to produce catheters that kill bacteria but are compatible with human cells. The promise of this new overcoat method is not based on any single characteristic but on an unprecedented combination of features. These include an “intelligent choice” for economical chemistry and processing. Proposed Phase II research is based on a promising paradigm- breaking approach coupled with in vitro and in vivo evaluations designed to assess feasibility and FDA requirements. A strong interdisciplinary team is dedicated to “bottoms up” biomaterials engineering that fills a strong need in the face of “top down” requirements to achieve such unprecedented capabilities economically. Indeed, PEG-LLC research promises to have a major impact not only on improving patient outcomes but in providing an economic benefit in reducing the rapidly rising cost of medical care. Key Words: catheters; overcoat; cell compatibility; antimicrobial;