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Antimicrobial catheters with cell and tissue compatibility

具有细胞和组织相容性的抗菌导管

基本信息

批准号：
9355628
负责人：
Kennard M Brunson
金额：
$ 82.1万
依托单位：
WYNNVISION, LLC
依托单位国家：
美国
项目类别：
财政年份：
2017
资助国家：
美国
起止时间：
2017-03-06 至 2020-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9355628
关键词：
Adhesions Adsorption Agar Aliquot Animal Model Antibiotics Award Bacteria Biocompatible Materials Candida albicans Catheters Cells Centers for Disease Control and Prevention (U.S.)Characteristics Charge Chemicals Chemistry Colony-forming units Coupled Disabled Persons Dyes Economics Effectiveness Elderly Engineering Enterobacter Enterococcus Environment Equilibrium Escherichia coli Evaluation Exposure to Goals Healthcare Heavy Metals Histocompatibility Human Immersion Investigative Technique Immunology In Vitro Incidence Infection Klebsiella pneumonia bacterium Laboratories Lead Length Measures Mechanics Medical Care Costs Methods Microbiology Modeling Modification Monitor Nitrogen Oryctolagus cuniculus Patient-Focused Outcomes Phase Polymers Preparation Process Pseudomonas aeruginosa Research Resistance Running ST14 gene Silicones Silver Small Business Innovation Research Grant Stroke Surface Suspensions Technology Testing Time United States National Institutes of Health Urine Validation Woman Work antimicrobial antimicrobial drug bacterial resistance base biomaterial compatibility catheter associated UTI density design flasks improved in vivo innovation killings medical complication medical schools novel strategies pathogen patient safety professor zeta potential

项目摘要

Polymer Exploration Group LLC PA-14-071 Abstract Project Title: Antimicrobial catheters with cell and tissue compatibility Abstract Catheter associated urinary tract infections (CAUTIs) are often encountered with subsequent antibiotic administration contributing to buildup of bacterial resistance. Leaving behind customary methods including release of silver and antimicrobials, PEG LLC is developing a new approach to produce catheters that kill bacteria but are compatible with human cells. The promise of this new overcoat method is not based on any single characteristic but on an unprecedented combination of features. These include an “intelligent choice” for economical chemistry and processing. Proposed Phase II research is based on a promising paradigm- breaking approach coupled with in vitro and in vivo evaluations designed to assess feasibility and FDA requirements. A strong interdisciplinary team is dedicated to “bottoms up” biomaterials engineering that fills a strong need in the face of “top down” requirements to achieve such unprecedented capabilities economically. Indeed, PEG-LLC research promises to have a major impact not only on improving patient outcomes but in providing an economic benefit in reducing the rapidly rising cost of medical care. Key Words: catheters; overcoat; cell compatibility; antimicrobial;

Polymer Exploration Group LLC PA-14-071摘要项目名称：具有细胞和组织相容性的抗菌导管摘要导尿管相关性尿路感染（CUTI）经常会遇到，抗生素给药有助于细菌耐药性的建立。留下常规方法，包括释放银和抗菌剂，PEG LLC正在开发一种新的这种方法可以生产出杀死细菌但与人体细胞相容的导管。的这种新的外涂层方法的前景不是基于任何单一的特性，而是基于前所未有的功能组合。其中包括经济型的“智能选择”，化学和加工。拟议的第二阶段研究是基于一个有前途的范例- 结合体外和体内评价的突破方法，旨在评估可行性 FDA的要求。一个强大的跨学科团队致力于“自下而上”的生物材料工程，填补了强烈的需要，在面对“自上而下”的要求，以实现这样的前所未有的经济实力。事实上，PEG-LLC的研究承诺将有一个主要的不仅对改善患者结局有影响，而且在减少迅速上涨的医疗费用。关键词：导管;涂层;细胞相容性;抗菌剂;