Antimicrobial catheters with and low protein and cell adhesion

具有低蛋白质和细胞粘附力的抗菌导管

• 批准号: 8979709
• 负责人: Kennard M Brunson
• 金额: $ 23.41万
• 依托单位: POLYMER EXPLORATION GROUP, LLC
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-07-08 至 2016-09-19
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8979709
• 关键词: Adhesions; Adsorption; Aging; Antibiotic Resistance; Antibiotics; Bacteria; Biocide; Biocompatible; Biocompatible Materials; Biological Assay; Bladder; Businesses; Candida albicans; Catheters; Cell Adhesion; Cell Adhesion Molecules; Cells; Characteristics; Charge; Coculture Techniques; Coupled; Deposition; Devices; Dimensions; Economics; Effectiveness; Elasticity; Elastomers; Engineering; Ensure; Environment; Escherichia coli; Film; Foreign-Body Reaction; Health Care Visit; Health care facility; Heavy Metals; Home environment; Hospitals; Host Defense Mechanism; Human; Immersion Investigative Technique; In Vitro; Incidence; Indwelling Catheter; Infection; Inflammatory; Label; Laboratories; Latex; Left; Life; Measurement; Measures; Mechanics; Medical; Medical Care Costs; Medical Device; Methods; Microbial Biofilms; Modeling; Modification; Nosocomial Infections; Outcome; Patients; Polyethylene Glycols; Polymers; Polyurethanes; Process; Property; Proteins; Pseudomonas aeruginosa; Research; Resistance; Resources; Roentgen Rays; Route; Sales; Silicones; Silver; Spectrum Analysis; Staining method; Stains; Staphylococcus aureus; Surface; Technology; Temperature; Testing; Thick; Time; Tissues; Toxic effect; Urethra; Urine; Validation; Weight; antimicrobial; bacterial resistance; bactericide; base; biomaterial compatibility; catheter associated UTI; chemical stability; crosslink; cytotoxicity; density; design; experience; flasks; hydrophilicity; improved; in vitro testing; innovation; killings; macrophage; new technology; novel; novel strategies; pathogen; polycation; public health relevance; research and development; residence; urinary; zeta potential

 DESCRIPTION (provided by applicant): Catheter associated urinary tract infections (CAUTIs) are often encountered with subsequent antibiotic administration contributing to buildup of bacterial resistance. Leaving behind customary methods including release of silver and antimicrobials, PEG LLC will develop a new approach whereby catheters are overcoated with a thin film that kills bacteria on contact but is compatible with human cells. The promise of this new overcoat method is not based on any single characteristic but on an unprecedented combination of features. These include an "intelligent choice" for an economical catheter overcoat that is cytocompatible, antimicrobial, and has a mechanical property match. Proposed R&D is based on a promising paradigm-breaking compositional approach coupled with in vitro tests designed to assess feasibility for catheter applications. The proposed "bottoms up" materials engineering fills a strong need in the face of "top down" requirements to achieve such unprecedented capability economically. Indeed, PEG- LLC overcoated catheters promise a major impact not only on improving patient outcomes but in providing an economic benefit in reducing the rapidly rising cost of medical care. Key Words: catheters; overcoat; cell compatibility; antimicrobial;

 描述(由申请人提供)：导管相关性尿路感染(CAUTIs)经常遇到，随后使用抗生素会导致细菌耐药性的增强。放弃了包括释放银和抗菌剂在内的常规方法，PEGLLC将开发一种新的方法，即在导管上覆盖一层薄膜，这种薄膜可以杀死接触到的细菌，但与人类细胞兼容。这种新的涂层方法的前景并不是基于任何单一的特征，而是基于前所未有的特征组合。其中包括一种经济的导管大衣的“智能选择”，这种大衣具有细胞相容性、抗菌和机械性能匹配的特点。建议的研发是基于一种有希望的打破范式的成分方法，结合体外测试，旨在评估导管应用的可行性。提出的“自下而上”的材料工程满足了面对“自上而下”的要求的强烈需求，以在经济上实现这种前所未有的能力。事实上，聚乙二醇LLC涂层导管不仅在改善患者预后方面有重大影响，而且在降低迅速上升的医疗成本方面也提供了经济效益。关键词：导尿管；大衣；细胞相容性；抗菌；