Antimicrobial catheters with and low protein and cell adhesion

 描述（由申请人提供）：导管相关尿路感染（CUTI）通常在随后的抗生素给药中发生，导致细菌耐药性的建立。抛开包括释放银和抗菌剂在内的常规方法，PEG LLC将开发一种新方法，即导管外涂一层薄膜，在接触时杀死细菌，但与人体细胞相容。这种新的外涂层方法的承诺不是基于任何单一的特征，而是基于前所未有的特征组合。这些包括一个“智能选择”的经济型导管外套，是细胞相容性，抗菌，并具有机械性能匹配。拟议的研发是基于一个有前途的打破范式的组成方法，再加上体外测试，旨在评估导管应用的可行性。所提出的“自下而上”的材料工程满足了面对“自上而下”的要求的强烈需求，以经济地实现这种前所未有的能力。事实上，PEG-LLC涂层导管不仅对改善患者预后有重大影响，而且在降低快速上涨的医疗成本方面提供了经济效益。关键词：导管;涂层;细胞相容性;抗菌剂;

 DESCRIPTION (provided by applicant): Catheter associated urinary tract infections (CAUTIs) are often encountered with subsequent antibiotic administration contributing to buildup of bacterial resistance. Leaving behind customary methods including release of silver and antimicrobials, PEG LLC will develop a new approach whereby catheters are overcoated with a thin film that kills bacteria on contact but is compatible with human cells. The promise of this new overcoat method is not based on any single characteristic but on an unprecedented combination of features. These include an "intelligent choice" for an economical catheter overcoat that is cytocompatible, antimicrobial, and has a mechanical property match. Proposed R&D is based on a promising paradigm-breaking compositional approach coupled with in vitro tests designed to assess feasibility for catheter applications. The proposed "bottoms up" materials engineering fills a strong need in the face of "top down" requirements to achieve such unprecedented capability economically. Indeed, PEG- LLC overcoated catheters promise a major impact not only on improving patient outcomes but in providing an economic benefit in reducing the rapidly rising cost of medical care. Key Words: catheters; overcoat; cell compatibility; antimicrobial;