TransPrEP: Social Network-Based PrEP Adherence for Transgender Women in Peru

TransPrEP：秘鲁跨性别女性基于社交网络的 PrEP 依从性

• 批准号: 9119194
• 负责人: JESSE LAWTON CLARK
• 金额: $ 14.16万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-08-01 至 2018-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9119194
• 关键词: AIDS prevention; Address; Adherence; Adoption; African; Area; Assessment tool; Behavior; Behavior Therapy; Behavioral; Behavioral Model; Biological; Clinical effectiveness; Communities; Control Groups; Counseling; Coupled; Couples; Data; Decision Making; Economics; Educational workshop; Effectiveness; Elements; Enrollment; Evaluation; Family; Financial compensation; Focus Groups; Funding; Geographic Locations; Goals; HIV; HIV Infections; HIV risk; Health; Health Promotion; Heterosexuals; Individual; Infection prevention; Information Dissemination; Intervention; Interview; Laboratories; Latin America; Life; Maintenance; Manuals; Measures; Modeling; Monitor; Neighborhoods; Network-based; Outcome; Participant; Patient Self-Report; Pattern; Peer Group; Peru; Pharmaceutical Preparations; Population; Prevalence; Prevention; Prevention approach; Prevention strategy; Preventive Intervention; Procedures; Process; Prophylactic treatment; Randomized; Randomized Controlled Trials; Recruitment Activity; Reporting; Research; Research Design; Risk; Risk Behaviors; Risk Reduction Behavior; Seeds; Serum; Sex Behavior; Sexually Transmitted Diseases; Social Network; Structure; System; Technology; Time; United States National Institutes of Health; Unsafe Sex; Woman; arm; base; behavior change; behavior influence; co-infection; compliance behavior; group counseling; high risk; meetings; men who have sex with men; neglect; novel strategies; peer; pill; primary outcome; secondary outcome; sex risk; social; social exclusion; social media; social norm; support network; support tools; theories; tool; transgender women; transmission process; truvada

DESCRIPTION (provided by applicant): The effectiveness of Pre-Exposure Prophylaxis (PrEP) for reducing HIV transmission is strongly dependent on adherence, which is influenced by individual, social, and structural factors. We propose a social network-based intervention to promote PrEP adherence among transgender women (TW) in Lima, Peru: 1) Formative research. To optimize content for a PrEP adherence intervention, we will conduct semi- structured interviews and focus groups. Results will be used to refine the PrEP adherence intervention. 2) To conduct an open evaluation of a social network-based PrEP adherence intervention for TW in Peru. The intervention model will be piloted with a small group of 5-10 TW. Data will be used to finalize the study design and assessment tools for a pilot randomized controlled trial (RCT). 3) To conduct a pilot RCT of a social network-based PrEP adherence intervention for TW in Peru. We plan to randomize 8 social network-based clusters of TW that to either a network-based PrEP adherence intervention or standardized PrEP adherence counseling. The primary outcome will be PrEP adherence. The intervention will use a combination of individual counseling, group workshops, social media-based network interactions, and practical support tools to promote PrEP adherence among TW. Individual Counseling: Participants will complete two biweekly counseling sessions addressing PrEP use and HIV prevention. The goals of individual counseling are to introduce PrEP as an HIV prevention tool and address basic issues of PrEP adherence as part of a comprehensive HIV prevention strategy. Group Workshops. Group workshops will establish a common understanding of PrEP as a central component of comprehensive HIV prevention, address the importance of PrEP adherence, develop practical strategies to support adherence, and generate and maintain norms of HIV prevention and PrEP adherence within the peer group. Biweekly maintenance meetings will address ongoing issues related to PrEP use and adherence. Social Network Interactions. The social network component of the intervention will include structured social media platforms to educate, motivate, and promote discussions of PrEP adherence within the participant network, unstructured participant-generated interactions to articulate and reinforce newly developed social norms within the network, and practical tools to support daily adherence. PrEP Use. Participants will be provided with daily Truvada for the 6-month study period. Assessment Procedures, Timing and Measures. There will be three major assessment points: baseline, short-term outcome (3 month), and long-term outcome (6 month). The primary outcome of the intervention will be a comparison of PrEP adherence in the intervention and control groups. Findings will be used to support an NIH-funded R01 proposal using social networks of TW and social media technologies to generate, implement, and reinforce new social norms of PrEP adherence, sexual risk behavior, and HIV prevention.

描述（由申请人提供）：暴露前预防（PrEP）减少HIV传播的有效性在很大程度上取决于依从性，而依从性受个人、社会和结构因素的影响。我们提出了一个基于社会网络的干预措施，以促进变性妇女（TW）在利马，秘鲁：1）形成性研究。为了优化PrEP依从性干预的内容，我们将进行半结构化访谈和焦点小组。结果将用于完善PrEP依从性干预。2)对秘鲁TW基于社交网络的PrEP依从性干预进行公开评价。干预模式将在5-10名TW的小组中进行试点。数据将用于完成一项初步随机对照试验（RCT）的研究设计和评估工具。3)在秘鲁对TW进行基于社交网络的PrEP依从性干预的试点RCT。我们计划将8个基于社交网络的TW集群随机分配给基于网络的PrEP依从性干预或标准化PrEP依从性咨询。主要结局将是PrEP依从性。该干预措施将结合个人咨询，小组研讨会，基于社交媒体的网络互动和实用的支持工具，以促进TW之间的PrEP依从性。个人咨询：参与者将完成两个双周咨询会议，解决PrEP使用和艾滋病毒预防。个人咨询的目标是引入PrEP作为艾滋病毒预防工具，并解决PrEP依从性的基本问题，作为全面艾滋病毒预防战略的一部分。小组研讨会。小组研讨会将建立对PrEP作为全面艾滋病毒预防的核心组成部分的共同理解，解决PrEP依从性的重要性，制定支持依从性的实用战略，并在同龄人群体中制定和维持艾滋病毒预防和PrEP依从性的规范。每两周举行一次的维护会议将解决与PrEP使用和依从性相关的持续问题。社交网络互动。干预的社交网络部分将包括结构化的社交媒体平台，以教育，激励和促进参与者网络内PrEP依从性的讨论，非结构化的参与者生成的互动，以阐明和加强网络内新开发的社会规范，以及支持日常依从性的实用工具。PrEP使用。在6个月的研究期间，将为受试者提供每日Truvada。评估程序、时间和措施。将有三个主要评估点：基线、短期结局（3个月）和长期结局（6个月）。干预的主要结果将是干预组和对照组中PrEP依从性的比较。研究结果将用于支持NIH资助的R 01提案，该提案使用TW的社交网络和社交媒体技术来生成、实施和加强PrEP依从性、性风险行为和艾滋病毒预防的新社会规范。

项目成果

Gender-affirming hormone therapy decreases d-dimer but worsens insulin sensitivity in transgender women.

性别肯定激素疗法会降低跨性别女性的 d-二聚体，但会恶化胰岛素敏感性。

• DOI: 10.1111/hiv.13522
• 发表时间: 2023
• 期刊: HIV medicine
• 影响因子: 3
• 作者: Lake,JordanE;Miao,Hongyu;Bowman,EmilyR;Clark,JesseL;Hyatt,AnaN;Kettelhut,Aaren;Lama,JavierR;Reisner,SariL;Mayer,KennethH;Perez-Brumer,Amaya;Funderburg,Nicholas
• 通讯作者: Funderburg,Nicholas

A global research synthesis of HIV and STI biobehavioural risks in female-to-male transgender adults.

全球研究的艾滋病毒和STI Biobehavioural风险的全球研究综合。

• DOI: 10.1080/17441692.2015.1134613
• 发表时间: 2016-08
• 期刊: Global public health
• 影响因子: 3.3
• 作者: Reisner SL;Murchison GR
• 通讯作者: Murchison GR