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Expedited Partner Therapy and the HIV Prevention Cascade Among MSM in Peru

秘鲁男男性行为者的快速伴侣治疗和艾滋病毒预防级联

基本信息

批准号：
10371882
负责人：
JESSE LAWTON CLARK
金额：
$ 59.18万
依托单位：
UNIVERSITY OF CALIFORNIA LOS ANGELES
依托单位国家：
美国
项目类别：
财政年份：
2019
资助国家：
美国
起止时间：
2019-06-01 至 2024-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10371882
关键词：
AIDS prevention Address Anti-Retroviral Agents Antibiotic Therapy Behavior Behavioral Biological Chlamydia Communities Complex Counseling Data Diagnosis Disease Distal Enrollment Evaluation Event Exposure to Gonorrhea HIV HIV therapy HIV/STD Heterosexuals High Prevalence Human immunodeficiency virus test Incidence Individual Infection Intervention Lead Literature Methods Modeling Notification Nucleic Acid Amplification Tests Outcome Participant Partner Notification Pathway interactions Patient Self-Report Patients Pattern Peru Peruvian Population Prevalence Prevention Publishing Randomized Recurrence Reporting Research Risk Risk Behaviors Risk Factors Sexual Partners Shame Site Site Visit Standardization Surveys Syphilis Telephone Testing Urethra arm base cohort condoms empowerment follow-up high risk high risk men intervention effect member men who have sex with men multidisciplinary neglect post intervention pre-exposure prophylaxis prevent prevention service recruit rectal sexual risk behavior social stigma standard of care success tool transmission process treatment as prevention treatment services uptake

项目摘要

PROJECT SUMMARY/ABSTRACT Expedited Partner Therapy (EPT) offers a unique tool to combine HIV prevention and STI control through an integrated HIV Prevention Cascade. In providing empiric, patient-delivered antibiotic treatment to the recent sexual partners of individuals with bacterial STIs, EPT promotes partner notification, HIV/STI testing, and treatment, and triggers the critical first step of an HIV prevention cascade culminating in uptake of antiretroviral-based prevention methods (such as PrEP or pre-exposure prophylaxis), and ultimately a reduction in community-level HIV transmission risk. By targeting the sexual partners of individuals with new STI diagnoses, EPT provides an opportunity to identify nodes of active HIV and STI transmission within high-risk sexual networks, to promote HIV testing and linkage to prevention and treatment services among these individuals, and to potentially reducing the incidence of HIV/STI transmission within the larger population. Use of EPT for HIV/STI control among MSM presents three key questions for future research: i) What is the impact of EPT on biological outcomes of persistent or recurrent bacterial STIs among MSM? ii) What is the effect of EPT on prevention cascade outcomes of partner HIV/STI testing and linkage to HIV prevention/treatment services? and iii) Would any observed increases in prevention cascade outcomes lead to community-level reductions in HIV/STI transmission? Aim 1 (Individual). To determine the effect of EPT on individual-level outcomes of partner notification and persistent or recurrent GC/CT infection among MSM. Aim 2 (Partnership). To assess the impact of EPT on partner-level outcomes of notification, testing, STI treatment, and linkage to HIV prevention and treatment services. Aim 3 (Population). To use Agent Based Modeling to estimate the impact of EPT for MSM on HIV/STI transmission at network- and population-levels.

项目总结/文摘