Expedited Partner Therapy and the HIV Prevention Cascade Among MSM in Peru

秘鲁男男性行为者的快速伴侣治疗和艾滋病毒预防级联

• 批准号: 10620659
• 负责人: JESSE LAWTON CLARK
• 金额: $ 59.1万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-06-01 至 2025-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10620659
• 关键词: AIDS prevention; Address; Anti-Retroviral Agents; Antibiotic Therapy; Behavior; Behavioral; Biological; Chlamydia; Communities; Complex; Counseling; Data; Diagnosis; Disease; Distal; Evaluation; Event; Exposure to; Gonorrhea; HIV; HIV therapy; HIV/STD; Heterosexuals; High Prevalence; Human immunodeficiency virus test; Incidence; Individual; Infection; Intervention; Lead; Literature; Methods; Modeling; Notification; Nucleic Acid Amplification Tests; Outcome; Participant; Partner Notification; Pathway interactions; Patient Self-Report; Patients; Pattern; Peru; Peruvian; Pharyngeal structure; Population; Prevalence; Prevention; Publishing; Randomized; Rectum; Recurrence; Reporting; Research; Risk; Risk Behaviors; Risk Factors; Risk Reduction; Sexual Partners; Shame; Site; Site Visit; Standardization; Surveys; Syphilis; Telephone; Testing; Urethra; arm; cohort; condoms; empowerment; follow-up; high risk; high risk men; intervention effect; member; men who have sex with men; multidisciplinary; neglect; participant enrollment; post intervention; pre-exposure prophylaxis; prevent; prevention service; recruit; rectal; sexual risk behavior; social stigma; standard of care; success; tool; transmission process; treatment as prevention; treatment services; uptake

PROJECT SUMMARY/ABSTRACT Expedited Partner Therapy (EPT) offers a unique tool to combine HIV prevention and STI control through an integrated HIV Prevention Cascade. In providing empiric, patient-delivered antibiotic treatment to the recent sexual partners of individuals with bacterial STIs, EPT promotes partner notification, HIV/STI testing, and treatment, and triggers the critical first step of an HIV prevention cascade culminating in uptake of antiretroviral-based prevention methods (such as PrEP or pre-exposure prophylaxis), and ultimately a reduction in community-level HIV transmission risk. By targeting the sexual partners of individuals with new STI diagnoses, EPT provides an opportunity to identify nodes of active HIV and STI transmission within high-risk sexual networks, to promote HIV testing and linkage to prevention and treatment services among these individuals, and to potentially reducing the incidence of HIV/STI transmission within the larger population. Use of EPT for HIV/STI control among MSM presents three key questions for future research: i) What is the impact of EPT on biological outcomes of persistent or recurrent bacterial STIs among MSM? ii) What is the effect of EPT on prevention cascade outcomes of partner HIV/STI testing and linkage to HIV prevention/treatment services? and iii) Would any observed increases in prevention cascade outcomes lead to community-level reductions in HIV/STI transmission? Aim 1 (Individual). To determine the effect of EPT on individual-level outcomes of partner notification and persistent or recurrent GC/CT infection among MSM. Aim 2 (Partnership). To assess the impact of EPT on partner-level outcomes of notification, testing, STI treatment, and linkage to HIV prevention and treatment services. Aim 3 (Population). To use Agent Based Modeling to estimate the impact of EPT for MSM on HIV/STI transmission at network- and population-levels.

项目总结/摘要 快速伴侣治疗提供了一个独特的工具，通过以下方式将联合收割机艾滋病毒预防和性传播感染控制结合起来： 艾滋病毒综合预防级联。在提供经验性，病人交付抗生素治疗，以最近 对于患有细菌性传播感染的个人，EPT促进伴侣通知，艾滋病毒/性传播感染检测， 治疗，并触发了艾滋病毒预防级联的关键的第一步，最终在摄取 基于抗逆转录病毒的预防方法（如PrEP或暴露前预防），最终 减少社区一级的艾滋病毒传播风险。通过针对新的性传播感染者的性伴侣 EPT提供了一个机会，可以在高风险地区确定活跃的艾滋病毒和性传播感染传播节点， 性网络，以促进艾滋病毒检测和与预防和治疗服务之间的联系， 艾滋病毒/性传播疾病的传播可能会减少，并可能减少更大人口中的艾滋病毒/性传播疾病传播发生率。 在男男性行为者中使用EPT控制艾滋病毒/性传播感染提出了未来研究的三个关键问题： i）EPT对MSM中持续性或复发性细菌性STI的生物学结局有何影响？ 二）紧急预防措施对伴侣艾滋病毒/性传播感染检测的预防级联结果以及与艾滋病毒的联系有何影响 预防/治疗服务？和 ㈢预防级联成果的任何观察到的增加是否会导致社区一级的 艾滋病毒/性传播感染？ 目标1（个人）。确定EPT对伴侣通知的个人水平结果的影响， MSM中持续或复发的GC/CT感染。 目标2（伙伴关系）。评估EPT对合作伙伴一级的通知、检测、STI结果的影响 治疗，以及与艾滋病毒预防和治疗服务的联系。 目标3（人口）。用基于Agent的建模方法评估MSM EPT对HIV/STI的影响 在网络和人口层面的传播。