ShEEP Request for UltraFocus DXA

这项建议是为了购买Faxitron UltraFocusDXA数字射线照相系统，这将增加高 分辨率双能X射线吸收(DEXA)能力与我们目前的成像能力-提供 更好的关于骨量、脂肪质量、瘦质量和高分辨率平面成像的纵向影响的数据 使用更少的动物和更短的时间-这也将有助于缓解我们拥挤扫描的压力 时间表。对这台设备感兴趣的实验室参与了广泛的资助项目 研究项目，包括骨代谢、骨科、癌症生物学、糖尿病和肥胖症。与 UltraFocus DXA系统，我们将能够在最大48微米和最小6微米的范围内扫描鼠标。 这将带来测量骨骼部分的可能性，这是我们目前无法做到的。使用 高分辨率平面X射线能力，我们将有能力筛查小鼠的肿瘤，成像骨骼 骨折，甚至评估皮质宽度和骨骼几何形状。On的床大小(摄像机/探测器大小) UltraFocus DXA系统比Piximus II系统大得多(10 X 15厘米)(目前已过时，但 只有可用的仪器)，可以容纳任何大小/重量/年龄的鼠标，甚至可以容纳大鼠。最后 鼠标DEXA(月球的Piximus II系统)单元生产于2005年。因为月球关闭了生产 这些研究单位，技术支持薄弱，修理单位的零部件变得非常稀缺。 在我们的退伍军人管理局收购最近引进的Faxitron UltraFocusDXA数字放射成像系统 将使我们能够获得可靠的服务和部件来满足我们的DEXA扫描需求(除了更好的质量外， 更快、更多功能的功能)。此外，UltraFocusDXA还可用于扫描许多 样本现在在旧的Piximus II系统上进行扫描，参数相同(或改进)，因此 释放现有(劣质)仪器的压力。有许多退伍军人管理局资助的调查人员 印第安纳波利斯退伍军人管理局将从收购Faxitron UltraFocusDXA数字射线照相术中受益匪浅 系统，包括Robling博士(骨质疏松)、MOE(慢性肾脏疾病)、Bellido(骨质疏松)、Roodman (多发性骨髓瘤)、Nakshatri(骨肉减少/恶病质)、Tholpady(颅面重建)和Evans-Molina (糖尿病/肥胖)。

This proposal is for the purchase of a Faxitron UltraFocusDXA Digital Radiography System, which will add high resolution dual energy x-ray absorptiometry (DEXA) capabilities to our present imaging capabilities—providing better data on longitudinal effects on bone mass, fat mass, lean mass, and high resolution planar imaging with the use of fewer animals and in less time—and which will also help relieve pressure on our crowded scanning schedule. The laboratories interested in this piece of equipment are involved in a wide range of funded research programs, including bone metabolism, orthopaedics, cancer biology, diabetes, and obesity. With the UltrafocusDXA system, we will be able to scan the mice at a maximum of 48 µm, and a minimum of 6 µm, which will usher in the possibility to measure parts of the skeleton that we are currently unable to do. Using the high resolution planar x-ray capability, we will have the capability to screen mice for tumors, image skeletal fractures, and even assess cortical width and bone geometry. The bed size (camera/detector size) of the on the UltrafocusDXA system is much larger (10 X 15 cm) than the Piximus II system (currently obsolete but the only instrument available) and can accommodate a mouse of any size/weight/age, and even rats. The last mouse DEXA (Lunar's Piximus II system) unit was produced in 2005. Because Lunar shut down production of these research units, technical support is weak and parts are becoming very scarce for repairing the units. Acquisition of the recently introduced Faxitron UltraFocusDXA Digital Radiography System at our VA facility would allow us to get reliable service and parts for our DEXA scanning needs (in addition to better quality, faster, and more versatile capabilities). In addition, the UltraFocusDXA can be used to scan many of the specimens now being scanned on the old Piximus II system, with identical (or improved) parameters, and so relieve pressure on the present (inferior) instrumentation. There are numerous VA-funded investigators at the Indianapolis VA that would benefit greatly from acquisition of the Faxitron UltraFocusDXA Digital Radiography System, including Drs. Robling (osteoporosis), Moe (chronic kidney disease), Bellido (osteoporosis), Roodman (multiple myeloma), Nakshatri (sarcopenia/cachexia), Tholpady (craniofacial reconstruction), and Evans-Molina (diabetes/obesity).