STUDIES OF NATURAL SIV INFECTION OF SOOTY MANGABEYS

乌白眉猴自然 SIV 感染的研究

• 批准号: 8884717
• 负责人: Guido Silvestri
• 金额: $ 81.36万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-03-01 至 2021-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8884717
• 关键词: Acquired Immunodeficiency Syndrome; Adenoviruses; Animals; Anti-Retroviral Agents; Area; Benign; Blood; CCR5 gene; CD4 Positive T Lymphocytes; Cells; Cercocebus atys; Chronic; Comprehension; Disease; Disease Progression; Down-Regulation; Equilibrium; Ethanol; Funding; HIV; HIV Infections; Helper-Inducer T-Lymphocyte; Homeostasis; Human; Immune; Immune response; In Vitro; Infection; Inflammatory; Instruction; Interleukin-12; Interleukin-15; Interruption; Kinetics; Knowledge; Laboratories; Macaca; Memory; Molecular; Nature; Pathogenesis; Pattern; Pharmaceutical Preparations; Prevention; Prevention therapy; Progress Reports; Research; Resistance; Role; SIV; Science; Series; Stem cells; Structure; System; T memory cell; T-Lymphocyte Subsets; Time; Translating; Vaccination; Viral reservoir; Viremia; Virus; Virus Diseases; Virus Replication; Work; abstracting; base; cytokine; immune activation; improved; in vivo; macrophage; microbial; pinacolyl methylphosphonic acid; prevent; programs; research study; transcriptome

Abstract: This proposal and progress report are intended to continue the work started in R37 AI066998. In the next funding cycle, we plan to expand this work in three broad areas that are outlined below. Area #1. To define the molecular mechanisms responsible for the differences in the pattern of infected cells between SIV-infected SMs and SIV-infected macaques and/or HIV-infected humans. Area #2. To characterize the relationship between the specific pattern of infected cells observed in SIV- infected SMs and their ability to avoid the chronic Immune activation of pathogenic HIV/SIV infections. Area #3. To determine how the SM-specific pattern of infected cells results in different features of the virus reservoir under anti-retroviral therapy (ART). We believe that these studies will advance significantly our understanding of how naturally SIV-infected SMs are resistant to AIDS despite high viremia. We envision that answering this question will provide clues to AIDS pathogenesis in humans that will have ultimately an impact on the prevention and treatment of HIV infection. RELEVANCE (See instructions): Sooty mangabeys do not progress to AIDS despite being naturally infected with SIV, a virus closely related to HIV. The proposed studies are aimed at understanding why the sooty mangabeys are able to remain healthy when infected with SIV. We believe that these studies will improve our comprehension of AIDS pathogenesis in humans and that this knowledge will ultimately translate in better prevention and therapies fnr thfi infection

抽象的： 该提案和进度报告旨在继续 R37 AI066998 中开始的工作。在接下来的 资金周期中，我们计划将这项工作扩展到下面概述的三个广泛领域。 区域#1。定义导致受感染细胞模式差异的分子机制 感染 SIV 的 SM 与感染 SIV 的猕猴和/或感染 HIV 的人类之间的差异。 区域#2。表征 SIV 中观察到的感染细胞的特定模式之间的关系 感染的 SM 及其避免致病性 HIV/SIV 感染的慢性免疫激活的能力。 区域#3。确定受感染细胞的 SM 特异性模式如何导致病毒的不同特征 抗逆转录病毒治疗（ART）下的储存库。 我们相信，这些研究将显着增进我们对 SIV 自然感染 SM 的理解。 尽管病毒血症较高，但仍能抵抗艾滋病。我们预计回答这个问题将为以下问题提供线索： 艾滋病在人类中的发病机制最终将对艾滋病毒的预防和治疗产生影响 感染。 相关性（参见说明）： 尽管乌白白眉猴自然感染了 SIV（一种与其密切相关的病毒），但它们不会发展为艾滋病。 艾滋病毒。拟议的研究旨在了解为什么乌黑白眉猴能够留下来 感染 SIV 后健康。我们相信这些研究将提高我们对艾滋病的理解 人类的发病机制，这些知识最终将转化为更好的预防和治疗 fnr thfi 感染