STUDIES OF NATURAL SIV INFECTION OF SOOTY MANGABEYS

乌白眉猴自然 SIV 感染的研究

• 批准号: 8884717
• 负责人: Guido Silvestri
• 金额: $ 81.36万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-03-01 至 2021-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8884717
• 关键词: Acquired Immunodeficiency Syndrome; Adenoviruses; Animals; Anti-Retroviral Agents; Area; Benign; Blood; CCR5 gene; CD4 Positive T Lymphocytes; Cells; Cercocebus atys; Chronic; Comprehension; Disease; Disease Progression; Down-Regulation; Equilibrium; Ethanol; Funding; HIV; HIV Infections; Helper-Inducer T-Lymphocyte; Homeostasis; Human; Immune; Immune response; In Vitro; Infection; Inflammatory; Instruction; Interleukin-12; Interleukin-15; Interruption; Kinetics; Knowledge; Laboratories; Macaca; Memory; Molecular; Nature; Pathogenesis; Pattern; Pharmaceutical Preparations; Prevention; Prevention therapy; Progress Reports; Research; Resistance; Role; SIV; Science; Series; Stem cells; Structure; System; T memory cell; T-Lymphocyte Subsets; Time; Translating; Vaccination; Viral reservoir; Viremia; Virus; Virus Diseases; Virus Replication; Work; abstracting; base; cytokine; immune activation; improved; in vivo; macrophage; microbial; pinacolyl methylphosphonic acid; prevent; programs; research study; transcriptome

Abstract: This proposal and progress report are intended to continue the work started in R37 AI066998. In the next funding cycle, we plan to expand this work in three broad areas that are outlined below. Area #1. To define the molecular mechanisms responsible for the differences in the pattern of infected cells between SIV-infected SMs and SIV-infected macaques and/or HIV-infected humans. Area #2. To characterize the relationship between the specific pattern of infected cells observed in SIV- infected SMs and their ability to avoid the chronic Immune activation of pathogenic HIV/SIV infections. Area #3. To determine how the SM-specific pattern of infected cells results in different features of the virus reservoir under anti-retroviral therapy (ART). We believe that these studies will advance significantly our understanding of how naturally SIV-infected SMs are resistant to AIDS despite high viremia. We envision that answering this question will provide clues to AIDS pathogenesis in humans that will have ultimately an impact on the prevention and treatment of HIV infection. RELEVANCE (See instructions): Sooty mangabeys do not progress to AIDS despite being naturally infected with SIV, a virus closely related to HIV. The proposed studies are aimed at understanding why the sooty mangabeys are able to remain healthy when infected with SIV. We believe that these studies will improve our comprehension of AIDS pathogenesis in humans and that this knowledge will ultimately translate in better prevention and therapies fnr thfi infection

摘要： 本提案和进度报告旨在继续R37 AI 066998中开始的工作。未来 在供资周期内，我们计划在下文概述的三个广泛领域扩大这项工作。 1号区域。确定感染细胞模式差异的分子机制 SIV感染的SM与SIV感染的猕猴和/或HIV感染的人类之间的差异。 2号区域。为了表征SIV中观察到的感染细胞的特异性模式之间的关系， 感染的SM及其避免致病性HIV/SIV感染的慢性免疫激活的能力。 3号区域。确定感染细胞的SM特异性模式如何导致病毒的不同特征 在抗逆转录病毒治疗（ART）下的水库。 我们相信这些研究将显着促进我们对SIV自然感染SM的了解 对艾滋病有抵抗力尽管病毒血症很高我们设想，回答这个问题将提供线索， 艾滋病在人类中的发病机制最终将影响艾滋病的防治 感染 相关性（参见说明）： 尽管自然感染了SIV（一种与SIV密切相关的病毒）， 艾滋病毒。拟议的研究旨在了解为什么不知名的白眉猴能够留在 感染SIV时是健康的我们相信这些研究将提高我们对艾滋病的理解 这些知识最终将转化为更好的预防和治疗方法， FNR THFI感染