STUDIES OF NATURAL SIV INFECTION OF SOOTY MANGABEYS

乌白眉猴自然 SIV 感染的研究

• 批准号: 8884717
• 负责人: Guido Silvestri
• 金额: $ 81.36万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-03-01 至 2021-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8884717
• 关键词: Acquired Immunodeficiency Syndrome; Adenoviruses; Animals; Anti-Retroviral Agents; Area; Benign; Blood; CCR5 gene; CD4 Positive T Lymphocytes; Cells; Cercocebus atys; Chronic; Comprehension; Disease; Disease Progression; Down-Regulation; Equilibrium; Ethanol; Funding; HIV; HIV Infections; Helper-Inducer T-Lymphocyte; Homeostasis; Human; Immune; Immune response; In Vitro; Infection; Inflammatory; Instruction; Interleukin-12; Interleukin-15; Interruption; Kinetics; Knowledge; Laboratories; Macaca; Memory; Molecular; Nature; Pathogenesis; Pattern; Pharmaceutical Preparations; Prevention; Prevention therapy; Progress Reports; Research; Resistance; Role; SIV; Science; Series; Stem cells; Structure; System; T memory cell; T-Lymphocyte Subsets; Time; Translating; Vaccination; Viral reservoir; Viremia; Virus; Virus Diseases; Virus Replication; Work; abstracting; base; cytokine; immune activation; improved; in vivo; macrophage; microbial; pinacolyl methylphosphonic acid; prevent; programs; research study; transcriptome

Abstract: This proposal and progress report are intended to continue the work started in R37 AI066998. In the next funding cycle, we plan to expand this work in three broad areas that are outlined below. Area #1. To define the molecular mechanisms responsible for the differences in the pattern of infected cells between SIV-infected SMs and SIV-infected macaques and/or HIV-infected humans. Area #2. To characterize the relationship between the specific pattern of infected cells observed in SIV- infected SMs and their ability to avoid the chronic Immune activation of pathogenic HIV/SIV infections. Area #3. To determine how the SM-specific pattern of infected cells results in different features of the virus reservoir under anti-retroviral therapy (ART). We believe that these studies will advance significantly our understanding of how naturally SIV-infected SMs are resistant to AIDS despite high viremia. We envision that answering this question will provide clues to AIDS pathogenesis in humans that will have ultimately an impact on the prevention and treatment of HIV infection. RELEVANCE (See instructions): Sooty mangabeys do not progress to AIDS despite being naturally infected with SIV, a virus closely related to HIV. The proposed studies are aimed at understanding why the sooty mangabeys are able to remain healthy when infected with SIV. We believe that these studies will improve our comprehension of AIDS pathogenesis in humans and that this knowledge will ultimately translate in better prevention and therapies fnr thfi infection

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