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Animal Core Facility

动物核心设施

基本信息

批准号：
8813060
负责人：
BIN GUO
金额：
$ 40.7万
依托单位：
NORTH DAKOTA STATE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2016
资助国家：
美国
起止时间：
2016-03-01 至 2021-02-28
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8813060
关键词：
Address Advisory Committees Animal Experiments Animal Model Animals Area Biomedical Research Cancer Etiology Cell model Centers of Research Excellence Cessation of life Clinical Clinical Management Core Facility Detection Diabetes Mellitus Diagnostic Digestive System Disorders Early Diagnosis Early treatment Ensure Equipment Erlotinib Experimental Designs Faculty Fluorouracil Fostering Goals Housing Human Resources IACUC Individual Institutes Institution Investigation Kidney Diseases Leadership Leucovorin Malignant neoplasm of pancreas Mentors Methods Mission Mus National Cancer Institute National Institute of General Medical Sciences Nude Mice Pilot Projects Postdoctoral Fellow Recruitment Activity Regimen Regulation Research Research Infrastructure Research Personnel Research Support Resources Rodent Model Scientist Senior Scientist Services Solid Testing Therapeutic Therapeutic Agents Toxic effect Training Transgenic Model Translational Research United States United States National Institutes of Health Xenograft procedure animal care animal facility anticancer research base cancer diagnosis cancer therapy career fundamental research gemcitabine graduate student high standard improved instrumentation irinotecan mouse model novel novel therapeutics objective response rate oxaliplatin phase 3 study programs protocol development research study response standard of care translational study treatment strategy

项目摘要

__________________________________________________________________________________________ Project Summary (Animal Core Facility) To enhance basic and translational studies devoted to the detection and treatment of pancreatic cancer, and to strengthen biomedical research at NDSU, we propose to establish a COBRE with a research focus on developing new strategies for the early diagnosis and treatment of pancreatic cancer. The proposed Center for Diagnostic and Therapeutic Strategies in Pancreatic Cancer at NDSU will be initially comprised of four thematically interrelated projects, each directed by a Junior Investigator. The resources available through the Center, in particular the Animal Core, will allow the Junior Investigators to utilize state-of-the-art methods to study the efficacy and toxicity of new therapeutic agents using mouse orthotopic xenograft and KPC transgenic models of pancreatic cancer. The four projects, together with the proposed Administrative Leadership, Animal Core Facility, Pilot Projects, and new faculty recruits, will propel this highly integrated group towards our goal to develop a sustainable center focused on pancreatic cancer research. The proposed Animal Core Facility will facilitate coordinated access to high standard animal service including animal care and experiments. The long-term goal of the Animal Core is to strengthen our institution's biomedical research infrastructure. This goal will be accomplished by establishing a premiere core facility that provides husbandry and housing for animal models as well as research support for the investigation of relevant biomedical questions. The primary focus of the Core will be on pancreatic cancer research. However, once established, the Animal Core will provide an outstanding platform for addressing a wide range of biomedical questions. The Animal Core has the following Specific Aims. 1) Establish the Animal Core Facility to foster excellence in pancreatic cancer research by expanding, and enhancing the existing NDSU animal facility. We will achieve this aim by recruiting essential personnel (manager and technician) and procuring state of the art equipment and research instrumentation. 2) Provide services for the scientific and animal needs of the individual Junior Investigators, Pilot Project Investigators, New and Existing Faculty, Postdoctoral Fellows, and graduate students associated with the five- year COBRE project. The services from the Core will include animal care and experiments, training, protocol development, and enforcing IACUC regulation. 3) Build a long-term sustainable Animal Core Research Platform. The Animal Core Facility will enable NDSU and collaborating scientists (including graduating COBRE investigators and others) to strengthen research programs and, as a result, be more competitive. The Animal Core will promote and sustain productive, extramurally-supported careers in biomedical research. __________________________________________________________________________________________

__________________________________________________________________________________________ 项目总结（动物核心机构）加强专门用于胰腺癌检测和治疗的基础和转化研究为了加强NDSU的生物医学研究，我们建议建立一个COBRE，专注于开发胰腺癌早期诊断和治疗的新策略。拟议 NDSU胰腺癌诊断和治疗策略中心最初将由以下人员组成：四个主题相互关联的项目，每个项目由一名初级研究员指导。通过以下途径获得的资源该中心，特别是动物核心，将允许初级研究人员利用最先进的方法，使用小鼠原位异种移植和KPC转基因研究新治疗剂的功效和毒性胰腺癌的模型。这四个项目，连同拟议的行政领导，动物核心设施，试点项目，和新的教师招聘，将推动这个高度整合的集团对我们的目标，建立一个专注于胰腺癌研究的可持续发展中心。拟议的动物核心设施将促进协调获得高标准的动物服务，包括动物护理和实验。动物核心的长期目标是加强我们机构的生物医学研究基础设施演进这一目标将通过建立一个一流的核心设施，提供畜牧业动物模型和住房以及相关生物医学研究的研究支持问题.核心的主要重点将是胰腺癌研究。然而，一旦建立，动物中心将为解决广泛的生物医学问题提供一个杰出的平台。的动物中心有以下具体目标。 1)建立动物核心设施，通过扩大，促进胰腺癌研究的卓越，加强现有的动物设施。我们将通过招聘必要的人员来实现这一目标（经理和技术员）和采购最先进的设备和研究仪器。 2)为初级研究者个人的科学和动物需求提供服务，试点项目研究人员，新的和现有的教师，博士后研究员，和研究生与五个- COBRE项目。核心的服务将包括动物护理和实验，培训，协议发展和执行IACUC法规。 3)建立长期可持续的动物核心研究平台。动物核心设施将使NDSU 和合作科学家（包括即将毕业的COBRE研究人员和其他人），以加强研究因此，我们的方案更具竞争力。动物核心将促进和维持生产力，在生物医学研究方面的校外支持的职业。 __________________________________________________________________________________________